PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium

Family

E2F/DP

Protein Properties

Length: 493aa MW: 54273.9 Da PI: 5.1566

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Cotton_A_39109_BGI-A2_v1.0	genome	BGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	84.8	6.7e-27	172	237	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+ lt+kf++l++++e+gi++ln++a++L +v ++RRiYDi+NVLe+++liekk kn+irwkg Cotton_A_39109_BGI-A2_v1.0 172 RYDSSLGFLTKKFINLIKHAEDGILDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNKIRWKG 237 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	1.3E-28	169	239	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	6.4E-34	172	237	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	7.98E-17	172	235	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	2.6E-24	174	237	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF144074	1.8E-32	249	353	No hit	No description
CDD	cd14660	3.07E-46	249	353	No hit	No description
Pfam	PF16421	5.0E-32	252	351	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005634	Cellular Component	nucleus
GO:0005667	Cellular Component	transcription factor complex
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 493 aa Download sequence Send to blast
MPYTSMSGVA RASACPTPPH PPPSVAAVSA PAPSAPSIVP PIRRHLAFAS MKPPFVHPDD 60 YHRLSSNNSN NNLTTGNNTR GIIADQEVEA IVVRSPKLKR KSTTVNKEVE SSQWTTSPRV 120 TSTANSPFQT PVSAKGGRIN NRSKASKANK SAPQTPVSNG SPAPLTPAGS CRYDSSLGFL 180 TKKFINLIKH AEDGILDLNK AAETLEVQKR RIYDITNVLE GIGLIEKKLK NKIRWKGVDD 240 SRPEADGDVS VLQAEIENLT MKEHTLDDQI RDMQERLRDL SENENNQRWL FVTEEDIKGL 300 PCFQNETLIA IKAPHGTTLE VPDPDEAVDY PQRRYRMILR STMGSIDVYL VSQFEKFEEV 360 NGVEPPASVS LASSSGSNEN QVELVNVDRT RKEIEPQAVQ THQMDCDVNA SLESVGGMMR 420 IVPSDIDNDA DYWLLSDVDV SITDMWKTDC VEWSGVDILD ANFGMADIST PTPQSPPSRM 480 VEVPSSAFNS THR

Sequence ? help Back to Top

Protein Sequence Length: 493 aa Download sequence Send to blast

MPYTSMSGVA RASACPTPPH PPPSVAAVSA PAPSAPSIVP PIRRHLAFAS MKPPFVHPDD  60
YHRLSSNNSN NNLTTGNNTR GIIADQEVEA IVVRSPKLKR KSTTVNKEVE SSQWTTSPRV  120
TSTANSPFQT PVSAKGGRIN NRSKASKANK SAPQTPVSNG SPAPLTPAGS CRYDSSLGFL  180
TKKFINLIKH AEDGILDLNK AAETLEVQKR RIYDITNVLE GIGLIEKKLK NKIRWKGVDD  240
SRPEADGDVS VLQAEIENLT MKEHTLDDQI RDMQERLRDL SENENNQRWL FVTEEDIKGL  300
PCFQNETLIA IKAPHGTTLE VPDPDEAVDY PQRRYRMILR STMGSIDVYL VSQFEKFEEV  360
NGVEPPASVS LASSSGSNEN QVELVNVDRT RKEIEPQAVQ THQMDCDVNA SLESVGGMMR  420
IVPSDIDNDA DYWLLSDVDV SITDMWKTDC VEWSGVDILD ANFGMADIST PTPQSPPSRM  480
VEVPSSAFNS THR

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	2e-23	167	238	2	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	JX578507	3e-59	JX578507.1 Gossypium hirsutum clone NBRI_GE10549 microsatellite sequence.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_017639495.1	0.0	PREDICTED: transcription factor E2FA-like
Swissprot	Q9FNY0	1e-175	E2FA_ARATH; Transcription factor E2FA
TrEMBL	A0A0B0N5Q7	0.0	A0A0B0N5Q7_GOSAR; Transcription factor E2FA-like protein
STRING	Gorai.002G157200.1	0.0	(Gossypium raimondii)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM808	28	121

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	1e-166	E2F transcription factor 3

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]