PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium

Family

ERF

Protein Properties

Length: 175aa MW: 19085.1 Da PI: 9.1498

Description

ERF family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Cotton_A_33523_BGI-A2_v1.0	genome	BGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	AP2	62.8	7.2e-20	22	72	2	56
AP2 2 gykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkklege 56 +y+GVr ++ +gr++AeIrdp++ ++r++lg+f+taeeAa+a++a +++++g+ Cotton_A_33523_BGI-A2_v1.0 22 RYRGVRKRP-WGRYAAEIRDPRK---KTRVWLGTFDTAEEAARAYDAKAREFRGA 72 59*****.******843...6***********************985 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS51032	23.709	22	79	IPR001471	AP2/ERF domain
Gene3D	G3DSA:3.30.730.10	1.8E-31	22	80	IPR001471	AP2/ERF domain
CDD	cd00018	7.74E-31	22	81	No hit	No description
SuperFamily	SSF54171	2.55E-22	22	81	IPR016177	DNA-binding domain
Pfam	PF00847	1.1E-13	22	71	IPR001471	AP2/ERF domain
SMART	SM00380	3.8E-34	22	85	IPR001471	AP2/ERF domain
PRINTS	PR00367	7.2E-12	23	34	IPR001471	AP2/ERF domain
PRINTS	PR00367	7.2E-12	45	61	IPR001471	AP2/ERF domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0009723	Biological Process	response to ethylene
GO:0009737	Biological Process	response to abscisic acid
GO:0009864	Biological Process	induced systemic resistance, jasmonic acid mediated signaling pathway
GO:0010200	Biological Process	response to chitin
GO:0045892	Biological Process	negative regulation of transcription, DNA-templated
GO:0016604	Cellular Component	nuclear body
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 175 aa Download sequence Send to blast
MAPRSKPSPI SPNPDPSSKE IRYRGVRKRP WGRYAAEIRD PRKKTRVWLG TFDTAEEAAR 60 AYDAKAREFR GAKAKTNFAD NNANDFTRSP SQSSTVESSP PPLDLTLASA CSSLPVTAQR 120 PVYFFDAFAT GGSGCPASGF AQSDSDSSSS VVDFEGGVRR RVFDLDLNQL PAEMD

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5wx9_A	9e-21	22	78	14	71	Ethylene-responsive transcription factor ERF096
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Acts as a transcriptional repressor. Binds to the GCC-box pathogenesis-related promoter element. Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways, and could also regulate other AtERFs. {ECO:0000269\|PubMed:10715325, ECO:0000269\|PubMed:11487705, ECO:0000269\|PubMed:9756931}.

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00358	DAP	Transfer from AT3G15210	Download

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Induced by jasmonate (JA) and by Alternaria brassicicola (locally and systemically), but only slightly by ethylene. Strong induction by wounding, cold or drought stress does not require EIN2, whereas induction by NaCl does. Transcripts accumulate in cycloheximide-treated plants, a protein synthesis inhibitor. Seems to not be influenced by exogenous abscisic acid (ABA), and heat stress. {ECO:0000269\|PubMed:10715325, ECO:0000269\|PubMed:12805630}.

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AY779339	0.0	AY779339.1 Gossypium hirsutum AP2/EREBP transcription factor ERF-1 mRNA, complete cds.
GenBank	KP780199	0.0	KP780199.1 Gossypium hirsutum C-repeat binding factor 16 (CBF16) mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_017605042.1	1e-124	PREDICTED: ethylene-responsive transcription factor 4-like
Swissprot	O80340	3e-43	ERF78_ARATH; Ethylene-responsive transcription factor 4
TrEMBL	A0A2P5XA32	1e-105	A0A2P5XA32_GOSBA; Uncharacterized protein
STRING	Gorai.009G375700.1	1e-105	(Gossypium raimondii)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM10	28	1650

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G15210.1	1e-25	ethylene responsive element binding factor 4

Publications ? help Back to Top
Duarte JM, et al. Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis. Mol. Biol. Evol., 2006. 23(2): p. 469-78 [PMID:16280546] Cao WH, et al. Modulation of ethylene responses affects plant salt-stress responses. Plant Physiol., 2007. 143(2): p. 707-19 [PMID:17189334] Lyons R, et al. The RNA-binding protein FPA regulates flg22-triggered defense responses and transcription factor activity by alternative polyadenylation. Sci Rep, 2013. 3: p. 2866 [PMID:24104185] Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Gao S, et al. A cotton miRNA is involved in regulation of plant response to salt stress. Sci Rep, 2016. 6: p. 19736 [PMID:26813144] Zhou X, et al. The ERF11 Transcription Factor Promotes Internode Elongation by Activating Gibberellin Biosynthesis and Signaling. Plant Physiol., 2016. 171(4): p. 2760-70 [PMID:27255484] Liu W, et al. The ethylene response factor AtERF4 negatively regulates the iron deficiency response in Arabidopsis thaliana. PLoS ONE, 2017. 12(10): p. e0186580 [PMID:29045490]