PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Home  TFext  BLAST  Prediction  Download  Help  About  Links  PlantRegMap
(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Cotton_A_30259_BGI-A2_v1.0
Organism
Gossypium arboreum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium
Family E2F/DP
Protein Properties Length: 351aa    MW: 38308.6 Da    PI: 4.3925
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Cotton_A_30259_BGI-A2_v1.0genomeBGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP871.4e-27111176171
                     E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                                 r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  Cotton_A_30259_BGI-A2_v1.0 111 RYDSSLGLLTRKFINLIKQAEDGILDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 176
                                 6899******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.4E-29108178IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467852.09E-17111174IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013729.9E-35111176IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.1E-24113176IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 351 aa     Download sequence    Send to blast
MKPPFMSPGG DYHHFASTES RRLADQKGDA IVVQSPRKSD VADREVESGD WARPPGYTEV  60
IGSPLQTPVS GKGGKAQKAS RLTKNSRSGP QIPASNLGSP GNNVTPTGPC RYDSSLGLLT  120
RKFINLIKQA EDGILDLNKA ADTLEVQKRR IYDITNVLEG IGLIEKKLKN RIQWKGLDVS  180
RPGEIDENVT TLQAEVENLS IEERCLDEQI SQFEEKFEEI QGADPPPNFP STSGLNENPA  240
TTMVPEESRG KEIEMQGQDD NKMCSDLNAS QDFVSGIMKI VPSDVDCDAD YWLLSDPSIS  300
IIDMWRTESL IEWSELGTLN EGYGMATVSS TCPQTPTSNA TEAPSANSTG K
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A2e-27106177274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_012485148.10.0PREDICTED: transcription factor E2FB-like isoform X7
SwissprotQ9FV712e-79E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A1R3J2P01e-156A0A1R3J2P0_COCAP; Uncharacterized protein
STRINGGorai.006G114300.11e-147(Gossypium raimondii)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM80828121
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.36e-82E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]