PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium

Family

E2F/DP

Protein Properties

Length: 306aa MW: 34059.9 Da PI: 4.3049

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Cotton_A_02626_BGI-A2_v1.0	genome	BGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	60.3	2.9e-19	16	61	21	71
E2F_TDP 21 eegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 e+g ++ln++a +L +v ++RRiYDi+NVLe+++liekk kn+i+wkg Cotton_A_02626_BGI-A2_v1.0 16 EDGSLDLNKAAGTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 61 6799********...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SMART	SM01372	4.0E-16	1	61	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	7.21E-13	14	62	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	2.7E-17	15	61	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Gene3D	G3DSA:1.10.10.10	2.5E-19	15	63	IPR011991	Winged helix-turn-helix DNA-binding domain
CDD	cd14660	2.42E-39	72	178	No hit	No description
SuperFamily	SSF144074	5.23E-33	73	177	No hit	No description
Pfam	PF16421	9.4E-34	77	176	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 306 aa Download sequence Send to blast
KSSKFGPQTP SSALAEDGSL DLNKAAGTLE VQKRRIYDIT NVLEGIGLIE KKLKNRIQWK 60 GLDVSRPGEV DENVATLQAE VENLHNQEHR LDGQIRKMQE RLRDLSEDEN NSKWLFVTEE 120 DIKSLPCFQN EMLIAIKAPH GTTLEVPDPD EDDDSLQRRY RLVLRSSMGP IDVYLVSQIE 180 EKFEEVQGVG LPSNLPSTSG LDENPAEVET QGQYINGMCL DHHVSQDFVS GIMKFVPSNL 240 DNDADYWLLS DPSVSITNIW RTESGIELNN FDILQYTGMA AGSTTQPQTP PLNAAEVPPP 300 GNSTGR

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5tuu_B	8e-18	69	178	5	110	Transcription factor E2F4
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:18424613}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_016729709.1	0.0	PREDICTED: transcription factor E2FB-like
Swissprot	Q9FV71	1e-104	E2FB_ARATH; Transcription factor E2FB
TrEMBL	A0A1U8MVV2	0.0	A0A1U8MVV2_GOSHI; transcription factor E2FB-like
STRING	Gorai.013G257100.1	0.0	(Gossypium raimondii)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM808	28	121

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G22220.2	1e-106	E2F transcription factor 1

Publications ? help Back to Top
Heyndrickx KS,Vandepoele K Systematic identification of functional plant modules through the integration of complementary data sources. Plant Physiol., 2012. 159(3): p. 884-901 [PMID:22589469] Wu M,Liu L,Hijazi H,Chan C A multi-layer inference approach to reconstruct condition-specific genes and their regulation. Bioinformatics, 2013. 29(12): p. 1541-52 [PMID:23610368] Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325]