PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Cla021422
Organism
Citrullus lanatus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Citrullus
Family bHLH
Protein Properties Length: 364aa    MW: 40737.5 Da    PI: 4.8895
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Cla021422genomeICuGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH38.32.4e-12167218155
                CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
        HLH   1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                +r++h ++Er+RR+++N+ +  Lr+l+P +   + ++ + a+i   A+e++++L+
  Cla021422 167 QRMTHIAVERNRRKQMNEHLRVLRSLMPGS---YVQRGDQASIIGGAIEFVRELE 218
                79****************************...9*****************9995 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd000831.91E-13165222No hitNo description
Gene3DG3DSA:4.10.280.101.2E-13165221IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474599.68E-17166236IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS5088815.428166217IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000101.1E-9167218IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003533.4E-9172223IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd048730.00139290354No hitNo description
PROSITE profilePS516718.642290364IPR002912ACT domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0010377Biological Processguard cell fate commitment
GO:0045597Biological Processpositive regulation of cell differentiation
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051782Biological Processnegative regulation of cell division
GO:0005634Cellular Componentnucleus
GO:0016597Molecular Functionamino acid binding
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 364 aa     Download sequence    Send to blast
MPPSFSSHQD LYNNQDQFMR SRPFETSADN ATGILTYFPA NPPPLQPITS PDKLSFAEVM  60
QFADFGPKLS LNRFDEDDEP PGIDPVYFLK FPVLNNERAE EAAAAGEEEA AETGGRLIVG  120
ELEEEDNFRN NNNINNNVNN NNNNNNNNNN KRKRGRTVKT SEEVESQRMT HIAVERNRRK  180
QMNEHLRVLR SLMPGSYVQR GDQASIIGGA IEFVRELEQL LQCLESQKRR RVLGEPPLVQ  240
GADTPASQQP PFVPGNFPGH QNEGQILETT AESKSCLADV EVKVVGFDAM IKILSRRRPG  300
QLIKAIAALE DLQLNILHTN ITTIEQTVLY SFNVKIASES RFTAEDIASS VQQIFGFIHA  360
NTGM
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1167178RMTHIAVERNRR
2227231KRRRV
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267, ECO:0000269|PubMed:24571519, ECO:0000269|PubMed:24654956}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269|PubMed:22442411}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_004133999.20.0PREDICTED: transcription factor FAMA
RefseqXP_011650878.10.0PREDICTED: transcription factor FAMA
SwissprotQ56YJ81e-133FAMA_ARATH; Transcription factor FAMA
TrEMBLA0A0A0L9F40.0A0A0A0L9F4_CUCSA; Uncharacterized protein
STRINGXP_008438368.10.0(Cucumis melo)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF104893340
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G24140.11e-121bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Matos JL, et al.
    Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module.
    Elife, 2015.
    [PMID:25303364]
  3. Chen L, et al.
    NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis.
    Development, 2016. 143(9): p. 1600-11
    [PMID:26989174]
  4. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  5. Han X, et al.
    Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.
    Plant Physiol., 2018. 176(4): p. 2871-2885
    [PMID:29496884]
  6. Li X,Yang R,Chen H
    The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
    PLoS ONE, 2018. 13(3): p. e0193458
    [PMID:29513733]