PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Cla008312
Organism
Citrullus lanatus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Citrullus
Family E2F/DP
Protein Properties Length: 324aa    MW: 36332.6 Da    PI: 9.3693
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Cla008312genomeICuGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP73.52.3e-232388171
    E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
               rk+ksL+ll+++fl+l+++     + l+++a++L    v  +rRRiYDi+NVLe+++++++k+kn+++w+g
  Cla008312 23 RKQKSLGLLCSNFLSLYNHDGVHSIGLDDAASRL---GV--ERRRIYDIVNVLESVGVLSRKAKNQYSWNG 88
               79*****************999************...**..****************************98 PP
2E2F_TDP542.8e-171171782071
    E2F_TDP  20 seegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                ++ ++++l+e+ak L+ +      +++k+RR+YDi+NVL+++nliek     ++k+++rw g
  Cla008312 117 AKVNMISLDEAAKLLLGDghnssIMRTKVRRLYDIANVLSSMNLIEKthttdTRKPAFRWLG 178
                34499*****************999**************************99*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.104.1E-261989IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467853.93E-162286IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013725.4E-282388IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023193.9E-202488IPR003316E2F/DP family, winged-helix DNA-binding domain
SMARTSM013722.4E-1699178IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.107.3E-15118179IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.18E-9118179IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023197.6E-14119178IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 324 aa     Download sequence    Send to blast
MAALPSSSAV PDSSSSRHHT YSRKQKSLGL LCSNFLSLYN HDGVHSIGLD DAASRLGVER  60
RRIYDIVNVL ESVGVLSRKA KNQYSWNGFG AIPKALQDLK EEGLRENCSA SDGNDYAKVN  120
MISLDEAAKL LLGDGHNSSI MRTKVRRLYD IANVLSSMNL IEKTHTTDTR KPAFRWLGVR  180
GKVKNEPTVL TESRKRAFGT DVTNVSYKKT KAESSAYQGL NHCLNMQKLV QCENSSQEDS  240
QNSQDQECER TSKSYQFGPF APVTVAKVGV SDNNNTKRTH DWESLSSTFR PQYHNQALNE  300
LFSHYVEAWK SWYSEAVKKP IQIS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A3e-1822103388Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankLN6819321e-149LN681932.1 Cucumis melo genomic scaffold, anchoredscaffold00001.
GenBankLN7132661e-149LN713266.1 Cucumis melo genomic chromosome, chr_12.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_023519131.10.0E2F transcription factor-like E2FE isoform X4
SwissprotQ8LSZ41e-101E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A1S3AW130.0A0A1S3AW13_CUCME; E2F transcription factor-like E2FE isoform X2
STRINGXP_004157798.10.0(Cucumis sativus)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF36683366
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G01330.17e-88DP-E2F-like protein 3
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]