PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Citrullus

Family

C2H2

Protein Properties

Length: 469aa MW: 51571.4 Da PI: 6.3667

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Cla003947	genome	ICuGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	13.2	0.00026	120	142	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 ++Cp+Cg+s+++ ++ +H ++ Cla003947 120 FECPICGQSYRSEEEVSVHADSC 142 89**************9998765 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
CDD	cd09212	7.63E-21	167	263	No hit	No description
SuperFamily	SSF143503	4.32E-17	177	241	IPR018997	PUB domain
SMART	SM00580	2.6E-17	180	247	IPR018997	PUB domain
Pfam	PF09409	2.5E-16	180	246	IPR018997	PUB domain
SuperFamily	SSF54236	9.82E-14	320	433	IPR029071	Ubiquitin-related domain
SMART	SM00166	0.0035	346	435	IPR001012	UBX domain
PROSITE profile	PS50033	11.653	349	433	IPR001012	UBX domain
Gene3D	G3DSA:3.10.20.90	1.2E-8	349	433	No hit	No description
Pfam	PF00789	1.6E-5	350	429	IPR001012	UBX domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0050832	Biological Process	defense response to fungus
GO:0005515	Molecular Function	protein binding

Sequence ? help Back to Top
Protein Sequence Length: 469 aa Download sequence Send to blast
MGDVKDKVKG FMKRFNNTLS SSSSSSSFKG QGRVLGSSSS GSTSSMPTRP SRNPISKPNP 60 VNPPSDSKPP LVNSIANGQN RSDLSNKSNP DRKPADGFDP FDSFITSGKR SGNGYSLNVF 120 ECPICGQSYR SEEEVSVHAD SCVNDSTAKG AEDPPTSDAE SRSELEACVA TFLSGKPSQG 180 SLDIVLKLLR NIVREPENSK FRKIRLSNPK IKEAIGEAVG GVELLEFVGF KLQEEDGEMW 240 AIMDVPTEEE INLLSKVIDS IDRPKLDEQQ KKASTASALI EPKKVDRQIR VFFAVPENVA 300 ANIELPDSFY KLSVEEVKRE AIMRKQKIAE SQLLVPKSYK EKQAKAARRK YTRTVIRIQF 360 PDGVVLQGVF SPWEPTIALY EFVSTALKEP GLEFELIHPV GVKRRTITHF PAEGERSKTL 420 DDEELVPSAL VKFRPIETDS VVFTGLRNEL LEIIEPLVSG SAVAPPAQV

Sequence ? help Back to Top

Protein Sequence Length: 469 aa Download sequence Send to blast

MGDVKDKVKG FMKRFNNTLS SSSSSSSFKG QGRVLGSSSS GSTSSMPTRP SRNPISKPNP  60
VNPPSDSKPP LVNSIANGQN RSDLSNKSNP DRKPADGFDP FDSFITSGKR SGNGYSLNVF  120
ECPICGQSYR SEEEVSVHAD SCVNDSTAKG AEDPPTSDAE SRSELEACVA TFLSGKPSQG  180
SLDIVLKLLR NIVREPENSK FRKIRLSNPK IKEAIGEAVG GVELLEFVGF KLQEEDGEMW  240
AIMDVPTEEE INLLSKVIDS IDRPKLDEQQ KKASTASALI EPKKVDRQIR VFFAVPENVA  300
ANIELPDSFY KLSVEEVKRE AIMRKQKIAE SQLLVPKSYK EKQAKAARRK YTRTVIRIQF  360
PDGVVLQGVF SPWEPTIALY EFVSTALKEP GLEFELIHPV GVKRRTITHF PAEGERSKTL  420
DDEELVPSAL VKFRPIETDS VVFTGLRNEL LEIIEPLVSG SAVAPPAQV

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5ifw_A	3e-12	304	433	23	146	Tether containing UBX domain for GLUT4
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Facilitates the interaction of SYP31 and CDC48A, thereby regulating an CDC48A membrane-associated function (Ref.8). Appears to act as a negative regulator mediating the powdery mildew-plant interaction (PubMed:19176722, PubMed:23301616). {ECO:0000269\|PubMed:19176722, ECO:0000269\|PubMed:23301616, ECO:0000269\|Ref.8}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Induced in response to powdery mildew and by benzothiadiazole (BTH) treatment. {ECO:0000269\|PubMed:19176722}.

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	LN681895	0.0	LN681895.1 Cucumis melo genomic scaffold, anchoredscaffold00005.
GenBank	LN713263	0.0	LN713263.1 Cucumis melo genomic chromosome, chr_9.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_011655442.1	0.0	PREDICTED: UBX domain-containing protein 6
Swissprot	Q9ZU93	0.0	PUX2_ARATH; Plant UBX domain-containing protein 2
TrEMBL	A0A0A0KUN7	0.0	A0A0A0KUN7_CUCSA; Uncharacterized protein
STRING	XP_004162868.1	0.0	(Cucumis sativus)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF8944	25	29

Publications ? help Back to Top
Suzuki T,Park H,Till EA,Lennarz WJ The PUB domain: a putative protein-protein interaction domain implicated in the ubiquitin-proteasome pathway. Biochem. Biophys. Res. Commun., 2001. 287(5): p. 1083-7 [PMID:11587532] Rancour DM,Park S,Knight SD,Bednarek SY Plant UBX domain-containing protein 1, PUX1, regulates the oligomeric structure and activity of arabidopsis CDC48. J. Biol. Chem., 2004. 279(52): p. 54264-74 [PMID:15498773] Chandran D,Rickert J,Cherk C,Dotson BR,Wildermuth MC Host cell ploidy underlying the fungal feeding site is a determinant of powdery mildew growth and reproduction. Mol. Plant Microbe Interact., 2013. 26(5): p. 537-45 [PMID:23301616]