PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Cla002141
Organism
Citrullus lanatus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Citrullus
Family C2H2
Protein Properties Length: 504aa    MW: 58060.7 Da    PI: 6.8642
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Cla002141genomeICuGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H211.70.00079206228123
                EEETTTTEEESSHHHHHHHHHHT CS
    zf-C2H2   1 ykCpdCgksFsrksnLkrHirtH 23 
                y C+ C    +rk++L+rH+r++
  Cla002141 206 YFCEFCLNFMKRKEQLQRHMRKC 228
                78*******************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF541605.04E-2454173IPR016197Chromo domain-like
Gene3DG3DSA:2.30.30.2701.4E-3755133No hitNo description
PfamPF117171.8E-2064121IPR025995RNA binding activity-knot of a chromodomain
CDDcd000241.61E-676122No hitNo description
SMARTSM002981.6E-577136IPR000953Chromo/chromo shadow domain
Gene3DG3DSA:2.30.30.2701.4E-37167217No hitNo description
PROSITE profilePS5172665.298172499IPR002717Histone acetyltransferase domain, MYST-type
SuperFamilySSF557294.16E-100173500IPR016181Acyl-CoA N-acyltransferase
Gene3DG3DSA:3.40.630.302.9E-66231407IPR016181Acyl-CoA N-acyltransferase
PfamPF018531.0E-62233417IPR002717Histone acetyltransferase domain, MYST-type
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006281Biological ProcessDNA repair
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0010224Biological Processresponse to UV-B
GO:0005634Cellular Componentnucleus
GO:0004402Molecular Functionhistone acetyltransferase activity
Sequence ? help Back to Top
Protein Sequence    Length: 504 aa     Download sequence    Send to blast
MGSIDVQSTN VENGSAAASA DGRQKPVPAD GLNQTSNEPD GTAPEKPKEL GPTKKRMSSM  60
LPLDVGTRVM CRWRDGKYHP VKVIERRKLQ ATGFSDYEYY VHYTEFNRRL DEWVKLDQLD  120
LDSVETVVDE KVEDKVTGLK MTRHQKRKID ETHVEGHEEL DAASLREHEE FTKVKNIATI  180
ELGRYEIETW YFSPFPPEYN DTTKLYFCEF CLNFMKRKEQ LQRHMRKCDL KHPPGDEIYR  240
CGTLSMFEVD GKKNKVYGQN LCYLAKLFLD HKTLYYDVDL FLFYVLCECD DRGCHMVGYF  300
SKFALYFWVV GKASSGCVGL AIEWEEKHSE ESYNLACILT LPPYQRKGYG KFLIAFFVIF  360
YETERSAYEL SKKEGKVGTP ERPLSDLGLV SYRGYWTRVL LDILKKHKAN ISIKDVLLVI  420
GLIWILLLGA LVIPLCQELS DMTAIKAEDI LNTLQSLELI QYRKGQHVIC ADPKVLDRHL  480
KAAGRGGLEV DVSKLIWTPY REQG
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4dnc_A1e-1021684991278Histone acetyltransferase KAT8
4dnc_B1e-1021684991278Histone acetyltransferase KAT8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtHistone acetyltransferase which may be involved in transcriptional activation. Acetylates 'Lys-5' of histone H4 (H4K5ac) (PubMed:16648464, PubMed:17877703). Essential for gametophyte development (PubMed:19040736). Negative regulator of flowering controlling the H4K5ac levels in the FLC chromatin (PubMed:23273925). {ECO:0000269|PubMed:16648464, ECO:0000269|PubMed:17877703, ECO:0000269|PubMed:19040736, ECO:0000269|PubMed:23273925}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated upon UV-B exposure. {ECO:0000269|PubMed:22170978}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_022939466.10.0histone acetyltransferase of the MYST family 2-like isoform X1
SwissprotQ9LXD70.0MYST2_ARATH; Histone acetyltransferase of the MYST family 2
TrEMBLA0A0A0KRK80.0A0A0A0KRK8_CUCSA; Histone acetyltransferase
STRINGXP_004170573.10.0(Cucumis sativus)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF70661011
Publications ? help Back to Top
  1. Kerschen A,Napoli CA,Jorgensen RA,Müller AE
    Effectiveness of RNA interference in transgenic plants.
    FEBS Lett., 2004. 566(1-3): p. 223-8
    [PMID:15147899]
  2. Earley K, et al.
    Erasure of histone acetylation by Arabidopsis HDA6 mediates large-scale gene silencing in nucleolar dominance.
    Genes Dev., 2006. 20(10): p. 1283-93
    [PMID:16648464]
  3. Latrasse D, et al.
    The MYST histone acetyltransferases are essential for gametophyte development in Arabidopsis.
    BMC Plant Biol., 2008. 8: p. 121
    [PMID:19040736]
  4. Campi M,D'Andrea L,Emiliani J,Casati P
    Participation of chromatin-remodeling proteins in the repair of ultraviolet-B-damaged DNA.
    Plant Physiol., 2012. 158(2): p. 981-95
    [PMID:22170978]
  5. Bari A,Orazova S,Ivashchenko A
    miR156- and miR171-binding sites in the protein-coding sequences of several plant genes.
    Biomed Res Int, 2013. 2013: p. 307145
    [PMID:23936788]
  6. Xu Y, et al.
    Arabidopsis MRG domain proteins bridge two histone modifications to elevate expression of flowering genes.
    Nucleic Acids Res., 2014. 42(17): p. 10960-74
    [PMID:25183522]
  7. Falcone Ferreyra ML, et al.
    AtPDCD5 Plays a Role in Programmed Cell Death after UV-B Exposure in Arabidopsis.
    Plant Physiol., 2016. 170(4): p. 2444-60
    [PMID:26884483]
  8. Raevsky AV,Sharifi M,Samofalova DA,Karpov PA,Blume YB
    3D structure prediction of histone acetyltransferase proteins of the MYST family and their interactome in Arabidopsis thaliana.
    J Mol Model, 2016. 22(11): p. 256
    [PMID:27709438]
  9. Fina JP,Masotti F,Rius SP,Crevacuore F,Casati P
    HAC1 and HAF1 Histone Acetyltransferases Have Different Roles in UV-B Responses in Arabidopsis.
    Front Plant Sci, 2017. 8: p. 1179
    [PMID:28740501]