PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Ciclev10030052m
Common NameCICLE_v10030052mg
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Citrus
Family bHLH
Protein Properties Length: 314aa    MW: 34920.4 Da    PI: 4.7326
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Ciclev10030052mgenomeICGCView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH30.37.4e-10130172855
                      HHHHHHHHHHHHHHHHHCTSCC.C...TTS-STCHHHHHHHHHHHHHHH CS
              HLH   8 rErrRRdriNsafeeLrellPk.askapskKlsKaeiLekAveYIksLq 55 
                       Er+RR ++++++  Lr l+P+ +      K++Ka+i   Av Y+++Lq
  Ciclev10030052m 130 SERKRRGKMKEKLYGLRALVPNiS------KMDKASIIGDAVSYLQELQ 172
                      6*********************66......******************9 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF474593.14E-17120188IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000835.91E-12120176No hitNo description
PROSITE profilePS5088815.04122171IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.101.2E-16124188IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003531.2E-12128177IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000101.6E-7130172IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0034756Biological Processregulation of iron ion transport
GO:0071281Biological Processcellular response to iron ion
GO:0071369Biological Processcellular response to ethylene stimulus
GO:0071732Biological Processcellular response to nitric oxide
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 314 aa     Download sequence    Send to blast
MDEFGNPLTL HAFIDDPNFD QFIDLIRGEN EDPLASFDCD LINGCFADTQ FIGSAQDDVF  60
GHFNGTAAGT MVSDDLTFVL NSSFPDLDGD MKGEHREEEN NGDDSSGATR TATTASTRNK  120
KADRSRTLVS ERKRRGKMKE KLYGLRALVP NISKMDKASI IGDAVSYLQE LQMQVRKLKA  180
EIASLEYSMA GSEKNQEPIQ KPKKTQVLSG NLQPICKKIM QIDVFQVEER RFYLRLVSSG  240
GQGVAVSLYK ALESLTSFDV QNFNFATEPE RLVLTFNLNV KDCEQNMNLP NLRLWVTGAL  300
LNQGFDVVTP FST*
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in roots and inflorescence, and to a lower extent, in leaves and stems. In roots, confined to the outer cell layers, specifically in the differentiation zone. Also detected in the endodermis and inner tissues of the central cylinder. {ECO:0000269|PubMed:12679534, ECO:0000269|PubMed:15539473, ECO:0000269|PubMed:15556641}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor. Essential protein involved in iron uptake responses. Regulates FRO2 at the level of mRNA accumulation and IRT1 at the level of protein accumulation. Confers enhanced iron mobilization responses at low iron supply. {ECO:0000269|PubMed:15539473, ECO:0000269|PubMed:15556641, ECO:0000269|PubMed:16117851}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: In roots by iron deficiency. Repressed by cytokinins. Induced by cold, UV, ethylene (ACC), jasmonic acid (JA), flagellin, and salicylic acid (SA) treatments. {ECO:0000269|PubMed:12679534, ECO:0000269|PubMed:15531708, ECO:0000269|PubMed:15539473, ECO:0000269|PubMed:15556641, ECO:0000269|PubMed:18397377}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006424447.10.0transcription factor FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR
SwissprotQ0V7X42e-94FIT_ARATH; Transcription factor FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR
TrEMBLA0A2H5Q2590.0A0A2H5Q259_CITUN; Uncharacterized protein
TrEMBLV4SB320.0V4SB32_9ROSI; Uncharacterized protein
STRINGXP_006424447.10.0(Citrus clementina)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM41872857
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G28160.17e-92FER-like regulator of iron uptake
Publications ? help Back to Top
  1. Schmid NB, et al.
    Feruloyl-CoA 6'-Hydroxylase1-dependent coumarins mediate iron acquisition from alkaline substrates in Arabidopsis.
    Plant Physiol., 2014. 164(1): p. 160-72
    [PMID:24246380]
  2. Doustaly F, et al.
    Uranium perturbs signaling and iron uptake response in Arabidopsis thaliana roots.
    Metallomics, 2014. 6(4): p. 809-21
    [PMID:24549117]
  3. Le CT, et al.
    ZINC FINGER OF ARABIDOPSIS THALIANA12 (ZAT12) Interacts with FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR (FIT) Linking Iron Deficiency and Oxidative Stress Responses.
    Plant Physiol., 2016. 170(1): p. 540-57
    [PMID:26556796]
  4. Yang L, et al.
    Carbon Monoxide Interacts with Auxin and Nitric Oxide to Cope with Iron Deficiency in Arabidopsis.
    Front Plant Sci, 2016. 7: p. 112
    [PMID:27014280]
  5. Zhou C, et al.
    Paenibacillus polymyxa BFKC01 enhances plant iron absorption via improved root systems and activated iron acquisition mechanisms.
    Plant Physiol. Biochem., 2016. 105: p. 162-173
    [PMID:27105423]
  6. Mai HJ,Pateyron S,Bauer P
    Iron homeostasis in Arabidopsis thaliana: transcriptomic analyses reveal novel FIT-regulated genes, iron deficiency marker genes and functional gene networks.
    BMC Plant Biol., 2016. 16(1): p. 211
    [PMID:27716045]
  7. Zhou C, et al.
    Exogenous Melatonin Improves Plant Iron Deficiency Tolerance via Increased Accumulation of Polyamine-Mediated Nitric Oxide.
    Int J Mol Sci, 2017.
    [PMID:27792144]
  8. Ezer D, et al.
    The G-Box Transcriptional Regulatory Code in Arabidopsis.
    Plant Physiol., 2017. 175(2): p. 628-640
    [PMID:28864470]
  9. Naranjo-Arcos MA, et al.
    Dissection of iron signaling and iron accumulation by overexpression of subgroup Ib bHLH039 protein.
    Sci Rep, 2017. 7(1): p. 10911
    [PMID:28883478]
  10. Kailasam S,Wang Y,Lo JC,Chang HF,Yeh KC
    S-Nitrosoglutathione works downstream of nitric oxide to mediate iron-deficiency signaling in Arabidopsis.
    Plant J., 2018. 94(1): p. 157-168
    [PMID:29396986]
  11. Cui Y, et al.
    Four IVa bHLH Transcription Factors Are Novel Interactors of FIT and Mediate JA Inhibition of Iron Uptake in Arabidopsis.
    Mol Plant, 2018. 11(9): p. 1166-1183
    [PMID:29960107]