PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Citrus

Family

C2H2

Protein Properties

Length: 568aa MW: 61282.2 Da PI: 8.3709

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Ciclev10023420m	genome	ICGC	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	17	1.6e-05	65	87	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 ++C++C+k F r nL+ H r H Ciclev10023420m 65 FVCEICNKGFQRDQNLQLHRRGH 87 89*******************88 PP
2	zf-C2H2	15.4	5.3e-05	141	163	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 +kC +C+k + +s+ k H++t+ Ciclev10023420m 141 WKCDKCSKKYAVQSDWKAHQKTC 163 58*******************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF57667	6.31E-8	64	87	No hit	No description
Gene3D	G3DSA:3.30.160.60	1.9E-5	64	87	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profile	PS50157	10.949	65	87	IPR007087	Zinc finger, C2H2
SMART	SM00355	0.017	65	87	IPR015880	Zinc finger, C2H2-like
PROSITE pattern	PS00028	0	67	87	IPR007087	Zinc finger, C2H2
SMART	SM00355	100	106	136	IPR015880	Zinc finger, C2H2-like
Gene3D	G3DSA:3.30.160.60	6.7E-5	129	162	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamily	SSF57667	6.31E-8	136	162	No hit	No description
SMART	SM00355	94	141	161	IPR015880	Zinc finger, C2H2-like

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0003676	Molecular Function	nucleic acid binding
GO:0046872	Molecular Function	metal ion binding

Sequence ? help Back to Top
Protein Sequence Length: 568 aa Download sequence Send to blast
MSNITGDEGS FSSGNTGEEV QQRIREKQQQ NLLNHVHGSS ASGPSDPNAE VVALSPTTLM 60 ATNRFVCEIC NKGFQRDQNL QLHRRGHNLP WKLRQRTTTE VRKRVYICPE PSCVHHNPAR 120 ALGDLTGIKK HFSRKHGEKK WKCDKCSKKY AVQSDWKAHQ KTCGTREYKC DCGTIFSRRD 180 SFITHRAFCD ALAEENNKVN QGLMDNLGQN MQSQMPELMS SMPLNTGGNN TSLGMSEFNN 240 FDPKNPMKSL PQDLVPMPFK SVNMGGGGGG GGGGMFSSSS GTLFGGPRSI SSSSSSLQLS 300 SNSSSGFNYL QDSKNGCLIS GTAHMSATAL LQKAAQMGAT ASSGINSPMM QKSFTNSMAG 360 PDQQLSSTNK TPAYGSIQKQ HNASYDQQHF PSQAAHEQQS NMMMQKATQD MSQLFDQHTG 420 AASTGGMNND MGIMFTGMYM SSGGGDHQGA AGLGFTKNME NEDSSGSSSL IQAGRNAMER 480 NSTTGPSRFG GSNVTGGGGG GGDMMTLDFM GIGGTRPANL HEQQQQRMEL EAMSHHQRVP 540 MMTPFHQQQL PHSHGDSVLE KPTLWDA*

Sequence ? help Back to Top

Protein Sequence Length: 568 aa Download sequence Send to blast

MSNITGDEGS FSSGNTGEEV QQRIREKQQQ NLLNHVHGSS ASGPSDPNAE VVALSPTTLM  60
ATNRFVCEIC NKGFQRDQNL QLHRRGHNLP WKLRQRTTTE VRKRVYICPE PSCVHHNPAR  120
ALGDLTGIKK HFSRKHGEKK WKCDKCSKKY AVQSDWKAHQ KTCGTREYKC DCGTIFSRRD  180
SFITHRAFCD ALAEENNKVN QGLMDNLGQN MQSQMPELMS SMPLNTGGNN TSLGMSEFNN  240
FDPKNPMKSL PQDLVPMPFK SVNMGGGGGG GGGGMFSSSS GTLFGGPRSI SSSSSSLQLS  300
SNSSSGFNYL QDSKNGCLIS GTAHMSATAL LQKAAQMGAT ASSGINSPMM QKSFTNSMAG  360
PDQQLSSTNK TPAYGSIQKQ HNASYDQQHF PSQAAHEQQS NMMMQKATQD MSQLFDQHTG  420
AASTGGMNND MGIMFTGMYM SSGGGDHQGA AGLGFTKNME NEDSSGSSSL IQAGRNAMER  480
NSTTGPSRFG GSNVTGGGGG GGDMMTLDFM GIGGTRPANL HEQQQQRMEL EAMSHHQRVP  540
MMTPFHQQQL PHSHGDSVLE KPTLWDA*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5b3h_C	3e-33	137	200	3	66	Zinc finger protein JACKDAW
5b3h_F	3e-33	137	200	3	66	Zinc finger protein JACKDAW
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Expression -- Description ? help Back to Top
Source	Description
Uniprot	TISSUE SPECIFICITY: Observed in vegetative tissues. Mainly expressed in hypocotyls, petioles, shoot apices, root tips, and trichomes, and, at low levels, in leaves, stems and flowers. {ECO:0000269\|PubMed:25035403}.

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor that acts as a positive regulator of gibberellin (GA) action, homeostasis and signaling. GA converts the GAF1 complex from transcriptional activator to repressor via the degradation of DELLA proteins. {ECO:0000269\|PubMed:25035403}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_006480107.1	0.0	protein indeterminate-domain 2-like
Swissprot	Q9SCQ6	1e-105	IDD2_ARATH; Zinc finger protein GAI-ASSOCIATED FACTOR 1
TrEMBL	V4VW00	0.0	V4VW00_9ROSI; Uncharacterized protein
STRING	XP_006444264.1	0.0	(Citrus clementina)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM15443	8	18

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G66730.1	3e-93	C2H2-like zinc finger protein

Link Out ? help Back to Top
Phytozome	Ciclev10023420m
Entrez Gene	18047904

Publications ? help Back to Top
Fukazawa J, et al. DELLAs function as coactivators of GAI-ASSOCIATED FACTOR1 in regulation of gibberellin homeostasis and signaling in Arabidopsis. Plant Cell, 2014. 26(7): p. 2920-38 [PMID:25035403] Moreno-Risueno MA, et al. Transcriptional control of tissue formation throughout root development. Science, 2015. 350(6259): p. 426-30 [PMID:26494755] Khare D, et al. Root avoidance of toxic metals requires the GeBP-LIKE 4 transcription factor in Arabidopsis thaliana. New Phytol., 2017. 213(3): p. 1257-1273 [PMID:27768815]