PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Ciclev10020979m
Common NameCICLE_v10020979mg
Organism
Citrus clementina
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Citrus
Family E2F/DP
Protein Properties Length: 342aa    MW: 38330.7 Da    PI: 9.625
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Ciclev10020979mgenomeICGCView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP79.82.4e-25113193171
          E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                      r+eksL+lltq+f++l+ +s+ g++tl+evak L+ +      +++k+RR+YDi+NVL+++nliek     ++k+++rw g
  Ciclev10020979m 113 RREKSLGLLTQNFVRLFVCSNVGMITLDEVAKLLLGDahntsVMRTKVRRLYDIANVLSSMNLIEKthtadTRKPAFRWLG 193
                      689**************************************999**************************99*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.5E-24108195IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013725.1E-32113193IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467855.85E-14115194IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023192.2E-20115193IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 342 aa     Download sequence    Send to blast
MPQSSSSTKV QDPSSRHYAY SRKQKSLGLL CSKRAKNKYT WKGFKAIPGA LQELKEAGLR  60
DAFTTLDGGN SAKGSDDEDD DEDDDSSSNP NPGSQSDSLN PRSAHKSSKN DSRREKSLGL  120
LTQNFVRLFV CSNVGMITLD EVAKLLLGDA HNTSVMRTKV RRLYDIANVL SSMNLIEKTH  180
TADTRKPAFR WLGVNRLEIG LADSLNLDES RKRTFGTDVT NISFKRKRMD TSINGDISQS  240
IKMEKQMKVD DLVRVVDGSN SENYVNQGPR SYQFGPFAPE SVPEVNTSKN NVKGAHDWES  300
LTSKYRPQYH NQALRDLFSH YMEAWQSWYT EVAGKTIRQI S*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A3e-213018560228Transcription factor E2F8
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1210227RKRTFGTDVTNISFKRKR
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Not detected during early S phase. Expressed at both the G1/S and S/G2 transitions, with a peak during G2. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:18787127}.
UniprotTISSUE SPECIFICITY: Expressed exclusively in mitotically dividing cells. Highly expressed in young leaves and mature flowers. Lower expression in young stalk and in young and mature flowers. {ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366}.
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_024044442.10.0E2F transcription factor-like E2FE
SwissprotQ8LSZ43e-94E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLV4VJT10.0V4VJT1_9ROSI; Uncharacterized protein
STRINGXP_006439729.10.0(Citrus clementina)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM63042743
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.23e-91DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]