PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Ciclev10018041m
Common NameCICLE_v10018041mg
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Citrus
Family E2F/DP
Protein Properties Length: 377aa    MW: 42394.7 Da    PI: 9.2383
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Ciclev10018041mgenomeICGCView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP71.59.4e-232590171
          E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                     rkeksL+ll++kflkl+++   + + l+++a++L    v  +rRRiYD++N+Le+++++++++kn ++w+g
  Ciclev10018041m 25 RKEKSLGLLCSKFLKLYNRDGVESIGLDDAASRL---GV--ERRRIYDVVNILESIGVVARQAKNLYSWQG 90
                     79*****************999************...**..****************************98 PP

2E2F_TDP74.41.2e-23149228271
          E2F_TDP   2 keksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                      +eksL+lltq+f+kl+ +s+ +++tl+++a +L+ +      +++k RR+YDi+NV++++nliek     ++k+++rw g
  Ciclev10018041m 149 REKSLWLLTQNFVKLFLCSDVDMITLDSAAMALLGDsnnstAMRTKIRRLYDIANVFSSMNLIEKthhpeSRKPAFRWLG 228
                      79***************************************9***********************9999999******87 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.1E-252392IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467857.62E-162488IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.3E-272590IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.1E-192690IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.101.9E-21146229IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.1E-30148228IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023197.4E-19150228IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.72E-12150229IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 377 aa     Download sequence    Send to blast
MSSSSSSSAF GFREAEPDGK QFYSRKEKSL GLLCSKFLKL YNRDGVESIG LDDAASRLGV  60
ERRRIYDVVN ILESIGVVAR QAKNLYSWQG FDAIPEALEV LKEEGLRENF NINGCTNSGN  120
VLNDNENEGS TCTVTDGQDS SSSKIESKRE KSLWLLTQNF VKLFLCSDVD MITLDSAAMA  180
LLGDSNNSTA MRTKIRRLYD IANVFSSMNL IEKTHHPESR KPAFRWLGWK GKPCNRSAGF  240
LDLNEPRKRV FGTDITNLRL KKNKVDSLTE KKSNPKLNVP KYFKHCNEES NPDESRLEQH  300
SKHKSKGFVY GPFTPASISG IHDSRSKNTK QVLDFASLAS TFRPKYHNEA VNGLFGHYVE  360
AWKSWYAEVG DKEQKT*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A3e-37242203228Transcription factor E2F8
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Most abundant in mid-S phase. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:15308755}.
UniprotTISSUE SPECIFICITY: High expression in young cotyledons and leaves, hypocotyls, shoot apical meristem, roots and mature pollen grains, moderate in developing trichomes, flowers and at early stages of developing anthers, and barely detectable in mature leaves. Not detected in primary root meristem, emerging lateral roots, pistils, developing embryos and siliques. {ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15308755}.
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Does not bind retinoblastoma-related proteins. Acts as a growth regulator but is not associated with changes in the expression of cell cycle marker genes or in nuclear ploidy levels. Has no effect on cell proliferation, but may repress cell wall biosynthesis genes during cell elongation in differentiated cells. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15308755}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006446434.10.0E2F transcription factor-like E2FF
RefseqXP_024047120.10.0E2F transcription factor-like E2FF
SwissprotQ8RWL01e-130E2FF_ARATH; E2F transcription factor-like E2FF
TrEMBLV4W1F00.0V4W1F0_9ROSI; Uncharacterized protein
STRINGXP_006446434.10.0(Citrus clementina)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM60032547
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G01330.11e-124DP-E2F-like protein 3
Publications ? help Back to Top
  1. Dohmann EM, et al.
    The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability.
    Development, 2008. 135(11): p. 2013-22
    [PMID:18434413]