PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Gentianales; Rubiaceae; Ixoroideae; Coffeeae; Coffea

Family

E2F/DP

Protein Properties

Length: 468aa MW: 51285.5 Da PI: 4.7985

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Cc06_g06370	genome	CGSC	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	84.9	6.4e-27	145	210	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++l++++e+gi++ln++a++L +v ++RRiYDi+NVLe+++liekk kn+i+wkg Cc06_g06370 145 RYDSSLGLLTKKFINLIKHAEDGILDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIHWKG 210 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	8.5E-29	142	212	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	3.1E-17	145	208	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	2.4E-34	145	210	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	3.1E-24	147	210	IPR003316	E2F/DP family, winged-helix DNA-binding domain
CDD	cd14660	3.27E-47	221	327	No hit	No description
SuperFamily	SSF144074	3.66E-33	224	327	No hit	No description
Pfam	PF16421	4.1E-32	226	325	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005634	Cellular Component	nucleus
GO:0005667	Cellular Component	transcription factor complex
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 468 aa Download sequence Send to blast
MSTPQAPSRG AAAGGRQIPQ PIKRHLPFSS MKPPFVPPED YHRFSTPAGA GTETVRIQDA 60 EAIVVKSPPI KRKSRTDNHE VSSTDWAASP GNTRTVSSPI CTPVSAKGGK AYGRSKVTKG 120 DMSGPSTPLS NAGSPAPLTP AGSCRYDSSL GLLTKKFINL IKHAEDGILD LNKAAETLEV 180 QKRRIYDITN VLEGIGLIEK KLKNRIHWKG LDASRPDEVE NDASILQAEV ENLSMEERRL 240 DDRIREMRER LRDLSEDEIN EKWLFVTEED IKTLPCFQNE TLIAIKAPHG TTLEVPDPDE 300 AVDYPQRRYR IILRSTMGPI DVYLVSQFEE KFEDVNGGEP SMRYALASSS GSNDNPAAET 360 AVYEKTGLVV GELAEQDTRM AADLDASHDY AGGMMKIVPS ENDADYWLLS DAGVSITDMW 420 KSDAGVEWNG VNMLHDEFGM SDISERPQTP PSGVVDMTYP AANATPR*

Sequence ? help Back to Top

Protein Sequence Length: 468 aa Download sequence Send to blast

MSTPQAPSRG AAAGGRQIPQ PIKRHLPFSS MKPPFVPPED YHRFSTPAGA GTETVRIQDA  60
EAIVVKSPPI KRKSRTDNHE VSSTDWAASP GNTRTVSSPI CTPVSAKGGK AYGRSKVTKG  120
DMSGPSTPLS NAGSPAPLTP AGSCRYDSSL GLLTKKFINL IKHAEDGILD LNKAAETLEV  180
QKRRIYDITN VLEGIGLIEK KLKNRIHWKG LDASRPDEVE NDASILQAEV ENLSMEERRL  240
DDRIREMRER LRDLSEDEIN EKWLFVTEED IKTLPCFQNE TLIAIKAPHG TTLEVPDPDE  300
AVDYPQRRYR IILRSTMGPI DVYLVSQFEE KFEDVNGGEP SMRYALASSS GSNDNPAAET  360
AVYEKTGLVV GELAEQDTRM AADLDASHDY AGGMMKIVPS ENDADYWLLS DAGVSITDMW  420
KSDAGVEWNG VNMLHDEFGM SDISERPQTP PSGVVDMTYP AANATPR*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	3e-24	140	211	2	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_027069049.1	0.0	transcription factor E2FA isoform X3
Refseq	XP_027176340.1	0.0	transcription factor E2FA isoform X3
Swissprot	Q9FNY0	1e-161	E2FA_ARATH; Transcription factor E2FA
TrEMBL	A0A068UQU0	0.0	A0A068UQU0_COFCA; Uncharacterized protein
STRING	VIT_08s0007g02510.t01	0.0	(Vitis vinifera)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA1077	24	84

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	1e-165	E2F transcription factor 3

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]