PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Gentianales; Rubiaceae; Ixoroideae; Coffeeae; Coffea

Family

E2F/DP

Protein Properties

Length: 403aa MW: 44547.3 Da PI: 8.9013

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Cc04_g15910	genome	CGSC	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	72.5	4.6e-23	35	100	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 rk+ksL+ll+++fl+l+ ++ +++ l+++a +L v +rRRiYDi+NVLe+++++++k+kn+++wkg Cc04_g15910 35 RKQKSLGLLCSNFLRLYDREGVETIGLDDAAARL---GV--ERRRIYDIVNVLESVGVLARKAKNRYTWKG 100 79***************999********.....****************************98 PP
2	E2F_TDP	72.6	4.3e-23	171	251	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 rkeksL lltq+f+kl+ + + ++++l+++ak L+++ ++ k+RR+YDi+NVL +++ iek ++k+++rw g Cc04_g15910 171 RKEKSLALLTQNFVKLFLCMDMDMISLDDAAKILLKNgkdpaMTRSKVRRLYDIANVLASMKFIEKthhpeTRKPAFRWLG 251 79*******************************9998899*****************99999*****87 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	1.2E-25	33	101	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	2.39E-15	35	98	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	4.3E-27	35	100	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	2.6E-20	36	100	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Gene3D	G3DSA:1.10.10.10	6.6E-23	167	252	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	3.2E-29	171	251	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	1.7E-17	172	251	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	1.27E-11	173	252	IPR011991	Winged helix-turn-helix DNA-binding domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005634	Cellular Component	nucleus
GO:0005667	Cellular Component	transcription factor complex
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 403 aa Download sequence Send to blast
MELLPSANQA YEAAAAAAAG GSGGGGGGSQ HIYCRKQKSL GLLCSNFLRL YDREGVETIG 60 LDDAAARLGV ERRRIYDIVN VLESVGVLAR KAKNRYTWKG FGAIPSALQL LKEQGMVTNE 120 NANDGTSSVK TSDDEEDDTY SNLSNYSSQN HNFNPISAPK LPQSSKYADN RKEKSLALLT 180 QNFVKLFLCM DMDMISLDDA AKILLKNGKD PAMTRSKVRR LYDIANVLAS MKFIEKTHHP 240 ETRKPAFRWL GMKGISESGA DPSAIDGSKK RAFGMDLTNM TVKRSKVEPV GDGGLQQGMK 300 EQLKAQVKRE ALEDEVLRPK LQIDSRASTR SYRFGPFAPV NAPQVAASED NKETQSHDWE 360 SLAATYRPQY HNQALRDLFA HYVEAWKSWY TEVAEIPIQL IS*

Sequence ? help Back to Top

Protein Sequence Length: 403 aa Download sequence Send to blast

MELLPSANQA YEAAAAAAAG GSGGGGGGSQ HIYCRKQKSL GLLCSNFLRL YDREGVETIG  60
LDDAAARLGV ERRRIYDIVN VLESVGVLAR KAKNRYTWKG FGAIPSALQL LKEQGMVTNE  120
NANDGTSSVK TSDDEEDDTY SNLSNYSSQN HNFNPISAPK LPQSSKYADN RKEKSLALLT  180
QNFVKLFLCM DMDMISLDDA AKILLKNGKD PAMTRSKVRR LYDIANVLAS MKFIEKTHHP  240
ETRKPAFRWL GMKGISESGA DPSAIDGSKK RAFGMDLTNM TVKRSKVEPV GDGGLQQGMK  300
EQLKAQVKRE ALEDEVLRPK LQIDSRASTR SYRFGPFAPV NAPQVAASED NKETQSHDWE  360
SLAATYRPQY HNQALRDLFA HYVEAWKSWY TEVAEIPIQL IS*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
4yo2_A	2e-36	35	243	4	228	Transcription factor E2F8
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Inhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11867638, ECO:0000269\|PubMed:15649366, ECO:0000269\|PubMed:18787127}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_027123815.1	0.0	E2F transcription factor-like E2FE isoform X1
Swissprot	Q8LSZ4	1e-111	E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBL	A0A068V311	0.0	A0A068V311_COFCA; Uncharacterized protein
STRING	XP_009607525.1	1e-159	(Nicotiana tomentosiformis)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA2522	24	57

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G48160.2	1e-113	DP-E2F-like 1

Publications ? help Back to Top
Chandran D, et al. Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid. Cell Host Microbe, 2014. 15(4): p. 506-13 [PMID:24721578] Wang Z, et al. Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis. PLoS ONE, 2016. 11(8): p. e0160684 [PMID:27505251] Heyman J,Polyn S,Eekhout T,De Veylder L Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1. Plant Physiol., 2017. 175(1): p. 303-313 [PMID:28698355]