PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Gentianales; Rubiaceae; Ixoroideae; Coffeeae; Coffea

Family

E2F/DP

Protein Properties

Length: 457aa MW: 50550.4 Da PI: 4.5413

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Cc01_g08610	genome	CGSC	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	86.6	1.9e-27	135	200	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++l++++e+gi++ln++a++L +v ++RRiYDi+NVLe+++liekk kn+i+wkg Cc01_g08610 135 RYDSSLGLLTKKFINLIKHAEDGILDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 200 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	4.1E-29	133	202	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	9.2E-35	135	200	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	2.9E-17	135	198	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	1.5E-24	137	200	IPR003316	E2F/DP family, winged-helix DNA-binding domain
CDD	cd14660	3.24E-47	211	317	No hit	No description
SuperFamily	SSF144074	5.75E-33	213	317	No hit	No description
Pfam	PF16421	1.7E-33	216	315	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0008284	Biological Process	positive regulation of cell proliferation
GO:0009733	Biological Process	response to auxin
GO:0010090	Biological Process	trichome morphogenesis
GO:0045893	Biological Process	positive regulation of transcription, DNA-templated
GO:0051302	Biological Process	regulation of cell division
GO:0051446	Biological Process	positive regulation of meiotic cell cycle
GO:0005634	Cellular Component	nucleus
GO:0005667	Cellular Component	transcription factor complex
GO:0005737	Cellular Component	cytoplasm
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 457 aa Download sequence Send to blast
MQQQQQQQQQ QVLKKQLPFT SMKPPFGDYH HFSTDPHRPP LEPEAVIVKS PPPAPPPLKR 60 KNDVVDVEVE SNDQNHGFGY TDAANVSAKT PVSGKVGKAQ KAPRMTKASR SGSQTPATNV 120 GSPSGNHLTP VGPCRYDSSL GLLTKKFINL IKHAEDGILD LNKAADTLEV QKRRIYDITN 180 VLEGIGLIEK KLKNRIQWKG LDVSRPGEVD ESVASLQADI ENLTMEEHRL DDQIREMQER 240 LRDLSEAENN QKWLFVTEED IKSLPCFQNE TLIAIKAPHG TTLEVPDPDE AVDYPQRRYR 300 IVLRSTMGPI DVYLVSQFEE KFEEINAVEA PPDIPSTSGV NENLATTSVT KESGGDNIQI 360 EEQEDNRMCS DIGTSQDFVS GIMKIVPDVD SDADYWLLSD ADVSITDMWR TESGVDWGDL 420 SAIQENYAMP SVSTPRAQTP PPHTTEVPSA TNVSGS*

Sequence ? help Back to Top

Protein Sequence Length: 457 aa Download sequence Send to blast

MQQQQQQQQQ QVLKKQLPFT SMKPPFGDYH HFSTDPHRPP LEPEAVIVKS PPPAPPPLKR  60
KNDVVDVEVE SNDQNHGFGY TDAANVSAKT PVSGKVGKAQ KAPRMTKASR SGSQTPATNV  120
GSPSGNHLTP VGPCRYDSSL GLLTKKFINL IKHAEDGILD LNKAADTLEV QKRRIYDITN  180
VLEGIGLIEK KLKNRIQWKG LDVSRPGEVD ESVASLQADI ENLTMEEHRL DDQIREMQER  240
LRDLSEAENN QKWLFVTEED IKSLPCFQNE TLIAIKAPHG TTLEVPDPDE AVDYPQRRYR  300
IVLRSTMGPI DVYLVSQFEE KFEEINAVEA PPDIPSTSGV NENLATTSVT KESGGDNIQI  360
EEQEDNRMCS DIGTSQDFVS GIMKIVPDVD SDADYWLLSD ADVSITDMWR TESGVDWGDL  420
SAIQENYAMP SVSTPRAQTP PPHTTEVPSA TNVSGS*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	2e-26	130	201	2	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
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Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:18424613}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_027162263.1	0.0	transcription factor E2FB
Swissprot	Q9FV71	1e-159	E2FB_ARATH; Transcription factor E2FB
TrEMBL	A0A068UEG0	0.0	A0A068UEG0_COFCA; Uncharacterized protein
STRING	XP_006424133.1	0.0	(Citrus clementina)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA1077	24	84

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G22220.2	1e-158	E2F transcription factor 1

Publications ? help Back to Top
Heyndrickx KS,Vandepoele K Systematic identification of functional plant modules through the integration of complementary data sources. Plant Physiol., 2012. 159(3): p. 884-901 [PMID:22589469] Wu M,Liu L,Hijazi H,Chan C A multi-layer inference approach to reconstruct condition-specific genes and their regulation. Bioinformatics, 2013. 29(12): p. 1541-52 [PMID:23610368] Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325]