PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Capsella

Family

HD-ZIP

Protein Properties

Length: 312aa MW: 35117.6 Da PI: 4.4561

Description

HD-ZIP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Cagra.1080s0021.1.p	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	Homeobox	57.3	2.6e-18	63	116	3	56
--SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHHH CS Homeobox 3 kRttftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRakek 56 k+++++ +q+++Le+ Fe ++++ e++ +LA++lgL+ rqV vWFqNrRa++k Cagra.1080s0021.1.p 63 KKRRLSINQVKALEKNFELENKLEPERKVKLAQELGLQPRQVAVWFQNRRARWK 116 5568999**********************************************9 PP
2	HD-ZIP_I/II	127.8	4.5e-41	62	154	1	93
HD-ZIP_I/II 1 ekkrrlskeqvklLEesFeeeekLeperKvelareLglqprqvavWFqnrRARtktkqlEkdyeaLkraydalkeenerLekeveeLree 90 ekkrrls +qvk+LE++Fe e+kLeperKv+la+eLglqprqvavWFqnrRAR+ktkqlEkdy +Lk+++d+l+++ ++L++++e+L +e Cagra.1080s0021.1.p 62 EKKRRLSINQVKALEKNFELENKLEPERKVKLAQELGLQPRQVAVWFQNRRARWKTKQLEKDYGVLKTQFDSLRHNFDSLRRDNESLLQE 151 69*************************************************************************************999 PP HD-ZIP_I/II 91 lke 93 +++ Cagra.1080s0021.1.p 152 ISK 154 976 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS50071	16.908	58	118	IPR001356	Homeobox domain
SuperFamily	SSF46689	1.92E-18	60	120	IPR009057	Homeodomain-like
SMART	SM00389	3.4E-17	61	122	IPR001356	Homeobox domain
CDD	cd00086	6.17E-15	63	119	No hit	No description
Pfam	PF00046	1.4E-15	63	116	IPR001356	Homeobox domain
Gene3D	G3DSA:1.10.10.60	3.2E-19	65	125	IPR009057	Homeodomain-like
PRINTS	PR00031	8.7E-6	89	98	IPR000047	Helix-turn-helix motif
PROSITE pattern	PS00027	0	93	116	IPR017970	Homeobox, conserved site
PRINTS	PR00031	8.7E-6	98	114	IPR000047	Helix-turn-helix motif
Pfam	PF02183	8.9E-17	118	159	IPR003106	Leucine zipper, homeobox-associated

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0009414	Biological Process	response to water deprivation
GO:0009788	Biological Process	negative regulation of abscisic acid-activated signaling pathway
GO:0045893	Biological Process	positive regulation of transcription, DNA-templated
GO:0005634	Cellular Component	nucleus
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0043565	Molecular Function	sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 312 aa Download sequence Send to blast
MKRLSSSSSD SVGGLISLCP TTSTDEQSPR RYGGREFQSM LEGYEEEEEA IVEERGHVGL 60 SEKKRRLSIN QVKALEKNFE LENKLEPERK VKLAQELGLQ PRQVAVWFQN RRARWKTKQL 120 EKDYGVLKTQ FDSLRHNFDS LRRDNESLLQ EISKLKTKLN GGGEEEEEEN NEAAEATESD 180 ISVKEEEVSL TEKITEPPSS PPQFLEHSDG LNYRSFTDLR ELLPLKAAAS SFAAAGSSDS 240 SDSSALLNEE SSSNVTVAAP VTVPVGNFFK FVKMEQTEDH DDFLSGEEAC EFFSDEQPPS 300 LHWYSTVDHW N*

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	110	118	RRARWKTKQ

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that may act as growth regulators in response to water deficit. Interacts with the core sequence 5'-CAATTATTA-3' of promoters in response to ABA and in an ABI1-dependent manner. Involved in the negative regulation of the ABA signaling pathway. {ECO:0000269\|PubMed:10527431, ECO:0000269\|PubMed:12065416}.

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00271	DAP	Transfer from AT2G22430	Download

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Cagra.1080s0021.1.p

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By water deficit, by abscisic acid (ABA) and by salt stress. Self expression regulation. {ECO:0000269\|PubMed:10527431, ECO:0000269\|PubMed:12065416, ECO:0000269\|PubMed:16055682}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AY060569	0.0	AY060569.1 Arabidopsis thaliana At2g22430/F14M13.17 mRNA, complete cds.
GenBank	AY063819	0.0	AY063819.1 Arabidopsis thaliana putative homeodomain transcription factor ATHB-6 (At2g22430) mRNA, complete cds.
GenBank	AY094457	0.0	AY094457.1 Arabidopsis thaliana At2g22430/F14M13.17 mRNA, complete cds.
GenBank	AY122903	0.0	AY122903.1 Arabidopsis thaliana At2g22430/F14M13.17 mRNA, complete cds.
GenBank	X67034	0.0	X67034.1 A.thaliana mRNA Athb-6.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_006294645.1	0.0	homeobox-leucine zipper protein ATHB-6
Swissprot	P46668	0.0	ATHB6_ARATH; Homeobox-leucine zipper protein ATHB-6
TrEMBL	R0HU11	0.0	R0HU11_9BRAS; Uncharacterized protein
STRING	Cagra.1080s0021.1.p	0.0	(Capsella grandiflora)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM545	28	143

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G22430.1	1e-142	homeobox protein 6

Link Out ? help Back to Top
Phytozome	Cagra.1080s0021.1.p

Publications ? help Back to Top
Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Song L, et al. A transcription factor hierarchy defines an environmental stress response network. Science, 2017. [PMID:27811239]