PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID CCG015838.1
Organism
Populus euphratica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Salicaceae; Saliceae; Populus
Family bHLH
Protein Properties Length: 412aa    MW: 46622.5 Da    PI: 4.7752
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
CCG015838.1genomeLZUView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH382.9e-12213264155
                  CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
          HLH   1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                  +r++h ++Er+RR+++N+ +  Lr+l+P +   + ++ + a+i   A+e++++L+
  CCG015838.1 213 QRMTHIAVERNRRKQMNEHLRVLRSLMPGS---YVQRGDQASIIGGAIEFVRELE 264
                  79****************************...9*****************9995 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:4.10.280.101.4E-13211267IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000831.33E-12211268No hitNo description
PROSITE profilePS5088815.428212263IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474591.31E-16212281IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000101.3E-9213264IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003533.4E-9218269IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd048738.85E-4338402No hitNo description
PROSITE profilePS516718.872338412IPR002912ACT domain
SuperFamilySSF550213.85E-5338402No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0010377Biological Processguard cell fate commitment
GO:0045597Biological Processpositive regulation of cell differentiation
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051782Biological Processnegative regulation of cell division
GO:0005634Cellular Componentnucleus
GO:0016597Molecular Functionamino acid binding
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 412 aa     Download sequence    Send to blast
MLLCSELYFS QGSFTELDYS LDHHHQQQDH LGLIKQRIGE TSGDDDCNNG MIDYMLNNPQ  60
QHQQQMSSGF CTSTSFDKLS FADVMQFADF GPKLALNQNK ISEEETGIDP VYFLKFPVLN  120
DKIEEQSIRV PQLGGENIEE MFTGVSSGEN RAGMVGEERG IREDEEARIS DNNSVQLQFL  180
GDQDLQNKNP IPEGKNKRKR PRTIKTSEEV ESQRMTHIAV ERNRRKQMNE HLRVLRSLMP  240
GSYVQRGDQA SIIGGAIEFV RELEQLLQCL ESQKRRRLMD DSSLAIQQPA QPAFFSPMPL  300
PNDQMKLVDF ETGLREETAE NKSCLADVEV KLLGFDAMIK ILSRRRPGQL IKAIAALEDL  360
QLNILHTNIT TIDQTVLYSF NVKIASDSGF TAEDIASSVQ QIFNFIHANS SI
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1213224RMTHIAVERNRR
2273277KRRRL
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267, ECO:0000269|PubMed:24571519, ECO:0000269|PubMed:24654956}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269|PubMed:22442411}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011045658.10.0PREDICTED: transcription factor FAMA isoform X1
SwissprotQ56YJ81e-147FAMA_ARATH; Transcription factor FAMA
TrEMBLB9GFX70.0B9GFX7_POPTR; Uncharacterized protein
STRINGPOPTR_0001s32160.10.0(Populus trichocarpa)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF104893340
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G24140.11e-138bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Matos JL, et al.
    Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module.
    Elife, 2015.
    [PMID:25303364]
  3. Chen L, et al.
    NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis.
    Development, 2016. 143(9): p. 1600-11
    [PMID:26989174]
  4. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  5. Han X, et al.
    Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.
    Plant Physiol., 2018. 176(4): p. 2871-2885
    [PMID:29496884]
  6. Li X,Yang R,Chen H
    The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
    PLoS ONE, 2018. 13(3): p. e0193458
    [PMID:29513733]