PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

CCG002721.2

Organism

Populus euphratica

Taxonomic ID

75702

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Salicaceae; Saliceae; Populus

Family

bHLH

Protein Properties

Length: 589aa MW: 64679.1 Da PI: 7.6074

Description

bHLH family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
CCG002721.2	genome	LZU	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HLH	32.1	2.1e-10	37	78	3	49
HHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHH CS HLH 3 rahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAve 49 ++h+e+ErrRR+riN +++Lr l+P +K++Ka+ L ++ CCG002721.2 37 KSHSEAERRRRERINAHLATLRGLVPCT-----EKMDKATLLAAVIS 78 58***********************8.....79**99987775 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS50888	14.78	34	83	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamily	SSF47459	3.4E-11	37	85	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Pfam	PF00010	3.1E-8	37	78	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Gene3D	G3DSA:4.10.280.10	3.9E-11	38	85	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SMART	SM00353	1.9E-9	40	89	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
CDD	cd04873	2.54E-4	118	186	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0046983	Molecular Function	protein dimerization activity

Sequence ? help Back to Top
Protein Sequence Length: 589 aa Download sequence Send to blast
MVSQALVLDV EKGELLKAPA RIGKMGISEA KAFAALKSHS EAERRRRERI NAHLATLRGL 60 VPCTEKMDKA TLLAAVISQV KEHKKNALEA CKGLLVPMDD DQVKVETYFD GTLHFKASIC 120 CDYRPELLSD LRNAIDALPL KMVSAEISTL GSRLKNEFVL TDRRNKNALD DAGAIQLLTN 180 SIHQTLTSVL EKGSASQEYS PRTTLPNKRR RVTFFDSSSS LLSDCCTYWM IDAKDAAAAA 240 AKRSIGGGFY APCSRSQVSN HLTLLAESLP TDENDQSSMP AISRGNRSRC PTQKSGGFHY 300 WFAFPALVLD PPAMLIESKC ALEWFTSEEI VGFYDPSHGK DPERIMVFAD MKSSLVIEAL 360 ITAPQGLNDR QIALNAVGWE RNANKLVSRC INLAKSMDRT RLAVSAADLN LKLMRWRVLP 420 SLNFDELSSI KCLLIGAGTL SCQFFLTDTR ESRWLPTFLS AHANKITITA ALGFDSFLVM 480 QHGPGPFSFA CDLKAEAANN LSADLDNLAL TDRMFAGGDM ANSNSSSGSS ELPLGILPHQ 540 IWGSLFHFSQ MMLVGRSSNS CTACCSTHPT YLEDLTGLTE YRSRQTLLN

Sequence ? help Back to Top

Protein Sequence Length: 589 aa Download sequence Send to blast

MVSQALVLDV EKGELLKAPA RIGKMGISEA KAFAALKSHS EAERRRRERI NAHLATLRGL  60
VPCTEKMDKA TLLAAVISQV KEHKKNALEA CKGLLVPMDD DQVKVETYFD GTLHFKASIC  120
CDYRPELLSD LRNAIDALPL KMVSAEISTL GSRLKNEFVL TDRRNKNALD DAGAIQLLTN  180
SIHQTLTSVL EKGSASQEYS PRTTLPNKRR RVTFFDSSSS LLSDCCTYWM IDAKDAAAAA  240
AKRSIGGGFY APCSRSQVSN HLTLLAESLP TDENDQSSMP AISRGNRSRC PTQKSGGFHY  300
WFAFPALVLD PPAMLIESKC ALEWFTSEEI VGFYDPSHGK DPERIMVFAD MKSSLVIEAL  360
ITAPQGLNDR QIALNAVGWE RNANKLVSRC INLAKSMDRT RLAVSAADLN LKLMRWRVLP  420
SLNFDELSSI KCLLIGAGTL SCQFFLTDTR ESRWLPTFLS AHANKITITA ALGFDSFLVM  480
QHGPGPFSFA CDLKAEAANN LSADLDNLAL TDRMFAGGDM ANSNSSSGSS ELPLGILPHQ  540
IWGSLFHFSQ MMLVGRSSNS CTACCSTHPT YLEDLTGLTE YRSRQTLLN

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
3rui_A	4e-16	444	579	144	315	Ubiquitin-like modifier-activating enzyme ATG7
3t7e_A	5e-16	444	579	148	319	Ubiquitin-like modifier-activating enzyme ATG7
3vh2_A	2e-15	378	579	275	608	Ubiquitin-like modifier-activating enzyme ATG7
3vh3_A	5e-16	444	579	144	315	Ubiquitin-like modifier-activating enzyme ATG7
3vh4_A	5e-16	444	579	144	315	Ubiquitin-like modifier-activating enzyme ATG7
4gsk_A	2e-15	378	579	274	607	Ubiquitin-like modifier-activating enzyme ATG7
4gsk_B	2e-15	378	579	274	607	Ubiquitin-like modifier-activating enzyme ATG7
4gsl_A	2e-15	378	579	274	607	Ubiquitin-like modifier-activating enzyme ATG7
4gsl_B	2e-15	378	579	274	607	Ubiquitin-like modifier-activating enzyme ATG7
5yec_A	5e-16	444	579	144	315	Ubiquitin-like modifier-activating enzyme ATG7
5yec_C	5e-16	444	579	144	315	Ubiquitin-like modifier-activating enzyme ATG7
Search in ModeBase

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	42	47	ERRRRE
2	207	211	KRRRV

Functional Description ? help Back to Top
Source	Description
UniProt	E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes. Involved in the senescence process (PubMed:12070171). Involved in the degradation of damaged peroxisomes (PubMed:24368788). Involved in the non-selective degradation of chlorophylls and photosynthetic proteins during stress-induced leaf yellowing (PubMed:24510943). {ECO:0000269\|PubMed:12070171, ECO:0000269\|PubMed:24368788, ECO:0000269\|PubMed:24510943}.

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AC214284	1e-119	AC214284.1 Populus trichocarpa clone POP076-F15, complete sequence.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Swissprot	Q94CD5	1e-33	ATG7_ARATH; Ubiquitin-like modifier-activating enzyme atg7
TrEMBL	A0A498JT70	1e-133	A0A498JT70_MALDO; Uncharacterized protein

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF8986	31	43

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G68810.1	6e-28	bHLH family protein

Publications ? help Back to Top
Doelling JH,Walker JM,Friedman EM,Thompson AR,Vierstra RD The APG8/12-activating enzyme APG7 is required for proper nutrient recycling and senescence in Arabidopsis thaliana. J. Biol. Chem., 2002. 277(36): p. 33105-14 [PMID:12070171] Hanaoka H, et al. Leaf senescence and starvation-induced chlorosis are accelerated by the disruption of an Arabidopsis autophagy gene. Plant Physiol., 2002. 129(3): p. 1181-93 [PMID:12114572] Ketelaar T,Voss C,Dimmock SA,Thumm M,Hussey PJ Arabidopsis homologues of the autophagy protein Atg8 are a novel family of microtubule binding proteins. FEBS Lett., 2004. 567(2-3): p. 302-6 [PMID:15178341] Yoshimoto K, et al. Processing of ATG8s, ubiquitin-like proteins, and their deconjugation by ATG4s are essential for plant autophagy. Plant Cell, 2004. 16(11): p. 2967-83 [PMID:15494556] Otegui MS, et al. Senescence-associated vacuoles with intense proteolytic activity develop in leaves of Arabidopsis and soybean. Plant J., 2005. 41(6): p. 831-44 [PMID:15743448] Thompson AR,Doelling JH,Suttangkakul A,Vierstra RD Autophagic nutrient recycling in Arabidopsis directed by the ATG8 and ATG12 conjugation pathways. Plant Physiol., 2005. 138(4): p. 2097-110 [PMID:16040659] Phillips AR,Suttangkakul A,Vierstra RD The ATG12-conjugating enzyme ATG10 Is essential for autophagic vesicle formation in Arabidopsis thaliana. Genetics, 2008. 178(3): p. 1339-53 [PMID:18245858] Svenning S,Lamark T,Krause K,Johansen T Plant NBR1 is a selective autophagy substrate and a functional hybrid of the mammalian autophagic adapters NBR1 and p62/SQSTM1. Autophagy, 2011. 7(9): p. 993-1010 [PMID:21606687] Lenz HD,Vierstra RD,Nürnberger T,Gust AA ATG7 contributes to plant basal immunity towards fungal infection. Plant Signal Behav, 2011. 6(7): p. 1040-2 [PMID:21617379] Wang Y,Nishimura MT,Zhao T,Tang D ATG2, an autophagy-related protein, negatively affects powdery mildew resistance and mildew-induced cell death in Arabidopsis. Plant J., 2011. 68(1): p. 74-87 [PMID:21645148] Wang Y,Wu Y,Tang D The autophagy gene, ATG18a, plays a negative role in powdery mildew resistance and mildew-induced cell death in Arabidopsis. Plant Signal Behav, 2011. 6(9): p. 1408-10 [PMID:21847024] Heyndrickx KS,Vandepoele K Systematic identification of functional plant modules through the integration of complementary data sources. Plant Physiol., 2012. 159(3): p. 884-901 [PMID:22589469] Yamaguchi M, et al. Noncanonical recognition and UBL loading of distinct E2s by autophagy-essential Atg7. Nat. Struct. Mol. Biol., 2012. 19(12): p. 1250-6 [PMID:23142983] Lee TA,Vande Wetering SW,Brusslan JA Stromal protein degradation is incomplete in Arabidopsis thaliana autophagy mutants undergoing natural senescence. BMC Res Notes, 2013. 6: p. 17 [PMID:23327451] Minina EA, et al. Autophagy mediates caloric restriction-induced lifespan extension in Arabidopsis. Aging Cell, 2013. 12(2): p. 327-9 [PMID:23331488] Zhou J, et al. NBR1-mediated selective autophagy targets insoluble ubiquitinated protein aggregates in plant stress responses. PLoS Genet., 2013. 9(1): p. e1003196 [PMID:23341779] Baldwin KL,Dinh EM,Hart BM,Masson PH CACTIN is an essential nuclear protein in Arabidopsis and may be associated with the eukaryotic spliceosome. FEBS Lett., 2013. 587(7): p. 873-9 [PMID:23454656] Farmer LM, et al. Disrupting autophagy restores peroxisome function to an Arabidopsis lon2 mutant and reveals a role for the LON2 protease in peroxisomal matrix protein degradation. Plant Cell, 2013. 25(10): p. 4085-100 [PMID:24179123] Shibata M, et al. Highly oxidized peroxisomes are selectively degraded via autophagy in Arabidopsis. Plant Cell, 2013. 25(12): p. 4967-83 [PMID:24368788] Sakuraba Y, et al. Delayed degradation of chlorophylls and photosynthetic proteins in Arabidopsis autophagy mutants during stress-induced leaf yellowing. J. Exp. Bot., 2014. 65(14): p. 3915-25 [PMID:24510943] Shin KD,Lee HN,Chung T A revised assay for monitoring autophagic flux in Arabidopsis thaliana reveals involvement of AUTOPHAGY-RELATED9 in autophagy. Mol. Cells, 2014. 37(5): p. 399-405 [PMID:24805779] Gully K,Hander T,Boller T,Bartels S Perception of Arabidopsis AtPep peptides, but not bacterial elicitors, accelerates starvation-induced senescence. Front Plant Sci, 2015. 6: p. 14 [PMID:25667591] Qi H, et al. TRAF Family Proteins Regulate Autophagy Dynamics by Modulating AUTOPHAGY PROTEIN6 Stability in Arabidopsis. Plant Cell, 2017. 29(4): p. 890-911 [PMID:28351989] Barros JAS, et al. Autophagy Deficiency Compromises Alternative Pathways of Respiration following Energy Deprivation in Arabidopsis thaliana. Plant Physiol., 2017. 175(1): p. 62-76 [PMID:28710132] Luo L, et al. Autophagy Is Rapidly Induced by Salt Stress and Is Required for Salt Tolerance in Arabidopsis. Front Plant Sci, 2017. 8: p. 1459 [PMID:28878796] Kang S,Shin KD,Kim JH,Chung T Autophagy-related (ATG) 11, ATG9 and the phosphatidylinositol 3-kinase control ATG2-mediated formation of autophagosomes in Arabidopsis. Plant Cell Rep., 2018. 37(4): p. 653-664 [PMID:29350244] Minina EA, et al. Transcriptional stimulation of rate-limiting components of the autophagic pathway improves plant fitness. J. Exp. Bot., 2018. 69(6): p. 1415-1432 [PMID:29365132] Zhao L, et al. Autophagy contributes to sulfonylurea herbicide tolerance via GCN2-independent regulation of amino acid homeostasis. Autophagy, 2018. 14(4): p. 702-714 [PMID:29377765]