PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; Caryophyllales; Chenopodiaceae; Betoideae; Beta

Family

C2H2

Protein Properties

Length: 513aa MW: 57833.8 Da PI: 6.2302

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Bv1_000840_pchj.t1	genome	TBVR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	21	8.5e-07	268	289	2	23
EETTTTEEESSHHHHHHHHHHT CS zf-C2H2 2 kCpdCgksFsrksnLkrHirtH 23 C++Cgk F+r nL+ H+r H Bv1_000840_pchj.t1 268 FCTICGKGFKRDANLRMHMRGH 289 6*******************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF57667	2.29E-5	265	292	No hit	No description
PROSITE profile	PS50157	12.03	267	294	IPR007087	Zinc finger, C2H2
SMART	SM00355	0.0026	267	289	IPR015880	Zinc finger, C2H2-like
Gene3D	G3DSA:3.30.160.60	1.9E-5	268	318	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE pattern	PS00028	0	269	289	IPR007087	Zinc finger, C2H2
SMART	SM00355	65	316	349	IPR015880	Zinc finger, C2H2-like
SMART	SM00355	39	354	376	IPR015880	Zinc finger, C2H2-like

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0010044	Biological Process	response to aluminum ion
GO:0010447	Biological Process	response to acidic pH
GO:0005634	Cellular Component	nucleus
GO:0003676	Molecular Function	nucleic acid binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0046872	Molecular Function	metal ion binding

Sequence ? help Back to Top
Protein Sequence Length: 513 aa Download sequence Send to blast
MNVKDRPNSE NWIKPSAFRN EVQQNSSLNN QSFTSFSSQE QSKWEDPSIL DYSMRIDPSF 60 SKFNQSSGNS SLLVGNPSNQ AKLPNQEGIQ MNQMLDDGNW DPRAMLNNLS FLEQKIHQLQ 120 ELVHMIVERR TQFPPNQDEL VIQQQQLITA DLTSIIVQLI STAGSLLPSM KHNLSAANPS 180 GLQLSRVLFP SQNNEAPAQR AVSDVKPVEQ SNQVDLMAKC VPEMNANMEE DHELKDDDDG 240 KEEEHLPPGS YEILQLEKEE ILAPHTHFCT ICGKGFKRDA NLRMHMRGHG DEYKTPAALA 300 KPNKECSSEK VLLKRYSCPF VGCKRNKEHK KFQPLKTILC VKNHYKRTHC DKSYICSRCH 360 TKKFSVIADL KTHEKHCGRD KWLCSCGTTF SRKDKLFGHI ALFQGHTPAI PSEEHKGTSG 420 LSNHAENSDS TNNLAIMGFS FGSNDVDGNG TQHMMDVKEN SVEDPFFSLL NYEYSLGGLQ 480 DFPQTNFDDS PSSFSFLMSE EKDGMVSGSH EVD

Sequence ? help Back to Top

Protein Sequence Length: 513 aa Download sequence Send to blast

MNVKDRPNSE NWIKPSAFRN EVQQNSSLNN QSFTSFSSQE QSKWEDPSIL DYSMRIDPSF  60
SKFNQSSGNS SLLVGNPSNQ AKLPNQEGIQ MNQMLDDGNW DPRAMLNNLS FLEQKIHQLQ  120
ELVHMIVERR TQFPPNQDEL VIQQQQLITA DLTSIIVQLI STAGSLLPSM KHNLSAANPS  180
GLQLSRVLFP SQNNEAPAQR AVSDVKPVEQ SNQVDLMAKC VPEMNANMEE DHELKDDDDG  240
KEEEHLPPGS YEILQLEKEE ILAPHTHFCT ICGKGFKRDA NLRMHMRGHG DEYKTPAALA  300
KPNKECSSEK VLLKRYSCPF VGCKRNKEHK KFQPLKTILC VKNHYKRTHC DKSYICSRCH  360
TKKFSVIADL KTHEKHCGRD KWLCSCGTTF SRKDKLFGHI ALFQGHTPAI PSEEHKGTSG  420
LSNHAENSDS TNNLAIMGFS FGSNDVDGNG TQHMMDVKEN SVEDPFFSLL NYEYSLGGLQ  480
DFPQTNFDDS PSSFSFLMSE EKDGMVSGSH EVD

Functional Description ? help Back to Top
Source	Description
UniProt	Probable transcription factor. Together with STOP2, plays a critical role in tolerance to major stress factors in acid soils such as proton H(+) and aluminum ion Al(3+). Required for the expression of genes in response to acidic stress (e.g. ALMT1 and MATE), and Al-activated citrate exudation. {ECO:0000269\|PubMed:17535918, ECO:0000269\|PubMed:18826429, ECO:0000269\|PubMed:19321711, ECO:0000269\|PubMed:23935008}.

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00196	ampDAP	Transfer from AT1G34370	Download

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By shock H(+) and Al(3+) treatments. {ECO:0000269\|PubMed:17535918}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_010676478.1	0.0	PREDICTED: protein SENSITIVE TO PROTON RHIZOTOXICITY 1
Swissprot	Q9C8N5	0.0	STOP1_ARATH; Protein SENSITIVE TO PROTON RHIZOTOXICITY 1
TrEMBL	A0A0K9R5A3	0.0	A0A0K9R5A3_SPIOL; Uncharacterized protein
STRING	XP_010676478.1	0.0	(Beta vulgaris)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G34370.2	1e-175	C2H2 family protein

Publications ? help Back to Top
Kobayashi Y, et al. Molecular and physiological analysis of Al³⁺ and H⁺ rhizotoxicities at moderately acidic conditions. Plant Physiol., 2013. 163(1): p. 180-92 [PMID:23839867] Yokosho K,Yamaji N,Ma JF Global transcriptome analysis of Al-induced genes in an Al-accumulating species, common buckwheat (Fagopyrum esculentum Moench). Plant Cell Physiol., 2014. 55(12): p. 2077-91 [PMID:25273892] Geng X, et al. LEUNIG_HOMOLOG transcriptional co-repressor mediates aluminium sensitivity through PECTIN METHYLESTERASE46-modulated root cell wall pectin methylesterification in Arabidopsis. Plant J., 2017. 90(3): p. 491-504 [PMID:28181322] Balzergue C, et al. Low phosphate activates STOP1-ALMT1 to rapidly inhibit root cell elongation. Nat Commun, 2017. 8: p. 15300 [PMID:28504266] Pelagio-Flores R,Esparza-Reynoso S,Garnica-Vergara A,López-Bucio J,Herrera-Estrella A Trichoderma-Induced Acidification Is an Early Trigger for Changes in Arabidopsis Root Growth and Determines Fungal Phytostimulation. Front Plant Sci, 2017. 8: p. 822 [PMID:28567051] Jiang F, et al. Identification and characterization of suppressor mutants of stop1. BMC Plant Biol., 2017. 17(1): p. 128 [PMID:28738784] Daspute AA, et al. Transcriptional Regulation of Aluminum-Tolerance Genes in Higher Plants: Clarifying the Underlying Molecular Mechanisms. Front Plant Sci, 2017. 8: p. 1358 [PMID:28848571] Sharma A,Wai CM,Ming R,Yu Q Diurnal Cycling Transcription Factors of Pineapple Revealed by Genome-Wide Annotation and Global Transcriptomic Analysis. Genome Biol Evol, 2017. 9(9): p. 2170-2190 [PMID:28922793] Zhang Y, et al. The Cell Cycle Checkpoint Regulator ATR Is Required for Internal Aluminum Toxicity-Mediated Root Growth Inhibition in Arabidopsis. Front Plant Sci, 2018. 9: p. 118 [PMID:29491872]