PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Dalbergieae; Arachis

Family

E2F/DP

Protein Properties

Length: 344aa MW: 39507.5 Da PI: 6.0929

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Aradu.87K05	genome	NCGR_PGC	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	82.9	2.7e-26	76	141	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf+ l+e ++ g+++ln+ a++L +v ++RRiYDi+NVLe+++liek++kn+irwkg Aradu.87K05 76 RYDSSLGLLTKKFVYLIEAADYGTLDLNKTAETL---EV--QKRRIYDITNVLEGIGLIEKTSKNHIRWKG 141 6899*************999********...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	6.3E-28	73	142	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	1.2E-33	76	141	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	1.63E-16	76	139	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	1.1E-24	78	141	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF144074	2.22E-25	153	255	No hit	No description
CDD	cd14660	3.17E-34	153	255	No hit	No description
Pfam	PF16421	3.3E-23	157	253	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0000902	Biological Process	cell morphogenesis
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0042023	Biological Process	DNA endoreduplication
GO:0051782	Biological Process	negative regulation of cell division
GO:0005667	Cellular Component	transcription factor complex
GO:0005730	Cellular Component	nucleolus
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0044212	Molecular Function	transcription regulatory region DNA binding
GO:0046982	Molecular Function	protein heterodimerization activity

Sequence ? help Back to Top
Protein Sequence Length: 344 aa Download sequence Send to blast
QLTQTCAINS FNFNNHNHNH TSNHRQLPPT FYNQTQPPIR AENQTTKSKL SRYTKHATHE 60 PNATEAPHLA AVNNCRYDSS LGLLTKKFVY LIEAADYGTL DLNKTAETLE VQKRRIYDIT 120 NVLEGIGLIE KTSKNHIRWK GCNGHGPQEL NYQLKRLKTE VESLYAEESA LDDCIRQKQE 180 LIKNLEENEN SQRYLFLTNE DILNLPCFQN QELIAIKAPK VSVVEVPDPE ELGFWHYKMT 240 VRSATGPIYI YLLSKKGLKC KGDTIEQVKL IDPSWNGNHC KMRDMILSER EADLKNPCEV 300 LTSPGSEAFG IHEITPMEFK MDDDYWFESD AGVTLTDLWV NNNF

Sequence ? help Back to Top

Protein Sequence Length: 344 aa Download sequence Send to blast

QLTQTCAINS FNFNNHNHNH TSNHRQLPPT FYNQTQPPIR AENQTTKSKL SRYTKHATHE  60
PNATEAPHLA AVNNCRYDSS LGLLTKKFVY LIEAADYGTL DLNKTAETLE VQKRRIYDIT  120
NVLEGIGLIE KTSKNHIRWK GCNGHGPQEL NYQLKRLKTE VESLYAEESA LDDCIRQKQE  180
LIKNLEENEN SQRYLFLTNE DILNLPCFQN QELIAIKAPK VSVVEVPDPE ELGFWHYKMT  240
VRSATGPIYI YLLSKKGLKC KGDTIEQVKL IDPSWNGNHC KMRDMILSER EADLKNPCEV  300
LTSPGSEAFG IHEITPMEFK MDDDYWFESD AGVTLTDLWV NNNF

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	4e-22	76	141	7	73	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
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Functional Description ? help Back to Top
Source	Description
UniProt	Involved in transcriptional repression. May act by repressing E2F-regulated genes in mature differentiated cells, but is not an antagonist of E2FA. Restricts cell division and is involved in the coordination between cell proliferation and endoreduplication during development. May play a role during the transition from skotomorphogenesis to photomorphogenesis. Regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(SKP2A) complex. {ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12468727, ECO:0000269\|PubMed:16920782, ECO:0000269\|PubMed:19662336}.

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00190	DAP	Transfer from AT1G47870	Download

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Aradu.87K05

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Down-regulated by light. {ECO:0000269\|PubMed:12468727, ECO:0000269\|PubMed:18424613}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_015934003.1	0.0	transcription factor E2FC isoform X1
Swissprot	Q9FV70	2e-89	E2FC_ARATH; Transcription factor E2FC
TrEMBL	A0A445BRI0	0.0	A0A445BRI0_ARAHY; Uncharacterized protein
STRING	XP_007136084.1	1e-138	(Phaseolus vulgaris)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF11885	25	29

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G47870.2	2e-91	E2F/DP family protein

Publications ? help Back to Top
Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325] Li B, et al. Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis. Plant Cell, 2018. 30(1): p. 178-195 [PMID:29317470] Huntley R, et al. The maize retinoblastoma protein homologue ZmRb-1 is regulated during leaf development and displays conserved interactions with G1/S regulators and plant cyclin D (CycD) proteins. Plant Mol. Biol., 1998. 37(1): p. 155-69 [PMID:9620273]