PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Dalbergieae; Arachis

Family

C2H2

Protein Properties

Length: 101aa MW: 11767.5 Da PI: 6.8972

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Aradu.79EIQ	genome	NCGR_PGC	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	16.1	3.2e-05	58	82	1	23
EEET..TTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCp..dCgksFsrksnLkrHirtH 23 + C+ Cgk F +s LkrH H Aradu.79EIQ 58 FICHyeGCGKKFLERSKLKRHFLIH 82 78*******************8877 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:3.30.160.60	2.3E-9	24	53	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profile	PS50157	8.683	29	58	IPR007087	Zinc finger, C2H2
SMART	SM00355	65	29	53	IPR015880	Zinc finger, C2H2-like
SuperFamily	SSF57667	7.66E-5	30	53	No hit	No description
SuperFamily	SSF57667	6.29E-9	53	94	No hit	No description
Gene3D	G3DSA:3.30.160.60	8.0E-13	55	78	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SMART	SM00355	0.007	58	82	IPR015880	Zinc finger, C2H2-like
PROSITE profile	PS50157	12.133	58	87	IPR007087	Zinc finger, C2H2
PROSITE pattern	PS00028	0	60	82	IPR007087	Zinc finger, C2H2
Gene3D	G3DSA:3.30.160.60	9.9E-5	79	95	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0003676	Molecular Function	nucleic acid binding
GO:0046872	Molecular Function	metal ion binding

Sequence ? help Back to Top
Protein Sequence Length: 101 aa Download sequence Send to blast
EDALKALQEK EKVPAIPEPE PEPTTEVLFL CNYEGCGKMF IDAGALRKYS PIHEERQFIC 60 HYEGCGKKFL ERSKLKRHFL IHTRESNFIC PREGYGKYDN C

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1ubd_C	6e-13	22	97	2	72	PROTEIN (YY1 ZINC FINGER DOMAIN)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Dual-function transcription factor with both repression and activation activities. Binds to 5'-CCATATT-3' motif in target gene promoters (e.g. ABR1) (PubMed:26961720). Binds also to G-rich DNA motif 5'-GGGGGCAGTGG-3' (PubMed:22508367). Regulates the expression of genes involved in diverse cellular pathways, including glucose metabolism, photosynthesis, phototropism and stress response (e.g. salt, drought and osmotic stress) (PubMed:22508367, PubMed:26961720). Regulates plant immunity, especially during necrotrophic fungal infection (e.g. B.cinerea) (PubMed:24451981). Binds to ABR1 promoter and promotes its expression, thus negatively regulating the abscisic acid (ABA) signaling pathway. Represses ABA- and salt-responsive genes expression (PubMed:26961720). {ECO:0000269\|PubMed:22508367, ECO:0000269\|PubMed:24451981, ECO:0000269\|PubMed:26961720}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Aradu.79EIQ

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Induced by abscisic acid (ABA) in an ABI1- and ABI4-dependent manner. Stimulated by stress conditions including high salt, osmotic stress (e.g. mannitol) and dehydration. May be induced by ABI4 but repressed by ABR1. Repressed by darkness but induced by light. {ECO:0000269\|PubMed:26961720}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_019464675.1	1e-47	PREDICTED: uncharacterized zinc finger protein At4g06634-like
Swissprot	Q2V3L3	4e-31	YY1_ARATH; Zinc finger transcription factor YY1
TrEMBL	A0A1J7HJD5	3e-46	A0A1J7HJD5_LUPAN; Uncharacterized protein
STRING	Migut.B00804.1.p	2e-43	(Erythranthe guttata)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF29015	2	2

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT4G06634.2	6e-31	C2H2 family protein

Publications ? help Back to Top
Kumekawa N,Hosouchi T,Tsuruoka H,Kotani H The size and sequence organization of the centromeric region of Arabidopsis thaliana chromosome 4. DNA Res., 2001. 8(6): p. 285-90 [PMID:11853315] Li T,Wu XY,Li H,Song JH,Liu JY A Dual-Function Transcription Factor, AtYY1, Is a Novel Negative Regulator of the Arabidopsis ABA Response Network. Mol Plant, 2016. 9(5): p. 650-661 [PMID:26961720] Wu XY,Li T A Casein Kinase II Phosphorylation Site in AtYY1 Affects Its Activity, Stability, and Function in the ABA Response. Front Plant Sci, 2017. 8: p. 323 [PMID:28348572]