PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Dalbergieae; Arachis

Family

E2F/DP

Protein Properties

Length: 547aa MW: 61241.3 Da PI: 5.7416

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Aradu.1PF9A	genome	NCGR_PGC	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	86.6	1.8e-27	246	311	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++l++++e+gi++ln++a++L +v ++RRiYDi+NVLe+++liekk kn+i+wkg Aradu.1PF9A 246 RYDSSLGLLTKKFINLIKQAEDGILDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 311 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	4.3E-29	244	313	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	8.0E-35	246	311	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	5.03E-17	246	309	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	1.3E-24	248	311	IPR003316	E2F/DP family, winged-helix DNA-binding domain
CDD	cd14660	1.21E-44	322	426	No hit	No description
SuperFamily	SSF144074	2.48E-30	324	426	No hit	No description
Pfam	PF16421	6.1E-32	327	426	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 547 aa Download sequence Send to blast
MSGTRAPPAA ASPSEQIMRR QLPLSTMKPP FAASVDYHRF APDHLHHNRR TVDHEPEAIV 60 VKSSVWITCL VVDLVELVAD ELEELNYGVH KVKCRLPSPS PHGSDILVLQ EGSKWLGKQF 120 RLNDFDYPNI GLGGFIIYTF LGILTTNGDI CLHVLRLHFS GGTFHISIYP IKQLKRKSNT 180 TDFEADSGDR VNHVSMGAAN NPFQTPKSGK IGKGGKSSRL TKCNRSGPQT PGSPSGNNLT 240 PVGPCRYDSS LGLLTKKFIN LIKQAEDGIL DLNKAADTLE VQKRRIYDIT NVLEGIGLIE 300 KKLKNRIQWK GLDVSRPGEP EDSFSSLQAE VENLTMKECR LDEQIREMQE RLSDLSENEN 360 SEKLLFVTEE DIKNLPCFQN ETLIAIKAPH GTTLEVSDPD EAVDYPQRRY RIVLRSTMGP 420 IDVYLVRYAY FSRILAVFLK HLPQGSFCYC HGKFEEKFEE INGADVAPEF QPTPEFKNHE 480 PTVVVEDNGR DIAVQGQDGQ IPSSDFTSTQ DFVSGIVKIV PSDVDSHADY WLLSDADVSI 540 TDMWRTE

Sequence ? help Back to Top

Protein Sequence Length: 547 aa Download sequence Send to blast

MSGTRAPPAA ASPSEQIMRR QLPLSTMKPP FAASVDYHRF APDHLHHNRR TVDHEPEAIV  60
VKSSVWITCL VVDLVELVAD ELEELNYGVH KVKCRLPSPS PHGSDILVLQ EGSKWLGKQF  120
RLNDFDYPNI GLGGFIIYTF LGILTTNGDI CLHVLRLHFS GGTFHISIYP IKQLKRKSNT  180
TDFEADSGDR VNHVSMGAAN NPFQTPKSGK IGKGGKSSRL TKCNRSGPQT PGSPSGNNLT  240
PVGPCRYDSS LGLLTKKFIN LIKQAEDGIL DLNKAADTLE VQKRRIYDIT NVLEGIGLIE  300
KKLKNRIQWK GLDVSRPGEP EDSFSSLQAE VENLTMKECR LDEQIREMQE RLSDLSENEN  360
SEKLLFVTEE DIKNLPCFQN ETLIAIKAPH GTTLEVSDPD EAVDYPQRRY RIVLRSTMGP  420
IDVYLVRYAY FSRILAVFLK HLPQGSFCYC HGKFEEKFEE INGADVAPEF QPTPEFKNHE  480
PTVVVEDNGR DIAVQGQDGQ IPSSDFTSTQ DFVSGIVKIV PSDVDSHADY WLLSDADVSI  540
TDMWRTE

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	3e-26	241	312	2	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Aradu.1PF9A

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:18424613}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_015951676.1	0.0	transcription factor E2FB isoform X6
Swissprot	Q9FV71	1e-125	E2FB_ARATH; Transcription factor E2FB
TrEMBL	A0A445E551	0.0	A0A445E551_ARAHY; Uncharacterized protein
STRING	XP_004506213.1	0.0	(Cicer arietinum)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF28725	2	2

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G22220.3	1e-122	E2F transcription factor 1

Publications ? help Back to Top
Heyndrickx KS,Vandepoele K Systematic identification of functional plant modules through the integration of complementary data sources. Plant Physiol., 2012. 159(3): p. 884-901 [PMID:22589469] Wu M,Liu L,Hijazi H,Chan C A multi-layer inference approach to reconstruct condition-specific genes and their regulation. Bioinformatics, 2013. 29(12): p. 1541-52 [PMID:23610368] Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325]