PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Aan018469

Organism

Artemisia annua

Taxonomic ID

35608

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae; Artemisiinae; Artemisia

Family

C2H2

Protein Properties

Length: 389aa MW: 44833.3 Da PI: 7.8108

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
gnl\|UG\|Aan#S41943280	PU_unref	Unigene	View CDS
gnl\|UG\|Aan#S41943537	PU_unref	Unigene	View CDS
PUT-183a-Artemisia_annua-152845	PU_ref	plantGDB	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	14.2	0.00013	83	105	3	23
ET..TTTEEESSHHHHHHHHHHT CS zf-C2H2 3 Cp..dCgksFsrksnLkrHirtH 23 C+ Cgk+F + Lk+H + H Aan018469 83 CSfeGCGKTFIDAGALKKHSNIH 105 77779**************9988 PP
2	zf-C2H2	13.2	0.00026	110	134	1	23
EEET..TTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCp..dCgksFsrksnLkrHirtH 23 ++C+ +Cgk F ++s LkrH H Aan018469 110 HVCHyeNCGKKFLDSSKLKRHFLIH 134 79*******************8877 PP
3	zf-C2H2	21	8.9e-07	140	164	1	23
EEET..TTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCp..dCgksFsrksnLkrHirtH 23 + Cp Cgk Fs nLk+H++tH Aan018469 140 FICPheGCGKAFSLDFNLKSHMKTH 164 78**********************9 PP
4	zf-C2H2	15.2	6e-05	170	194	1	23
EEET..TTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCp..dCgksFsrksnLkrHirtH 23 + Cp Cgk++ + + Lk+H+++H Aan018469 170 HICPfrECGKRYAHEYKLKKHMMSH 194 68**********************6 PP
5	zf-C2H2	13.7	0.00018	240	265	1	23
EEET..TTTEEESSHHHHHHHHHH.T CS zf-C2H2 1 ykCp..dCgksFsrksnLkrHirt.H 23 y Cp C+k + + + L+ H+r+ H Aan018469 240 YACPydSCDKAYIHEYKLNLHLRReH 265 89*********************999 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:3.30.160.60	1.6E-12	76	107	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SMART	SM00355	0.0035	81	105	IPR015880	Zinc finger, C2H2-like
PROSITE profile	PS50157	10.949	81	110	IPR007087	Zinc finger, C2H2
PROSITE pattern	PS00028	0	83	105	IPR007087	Zinc finger, C2H2
SuperFamily	SSF57667	5.98E-8	83	134	No hit	No description
Gene3D	G3DSA:3.30.160.60	8.6E-13	108	130	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SMART	SM00355	0.077	110	134	IPR015880	Zinc finger, C2H2-like
PROSITE profile	PS50157	13.38	110	139	IPR007087	Zinc finger, C2H2
PROSITE pattern	PS00028	0	112	134	IPR007087	Zinc finger, C2H2
SuperFamily	SSF57667	5.08E-14	121	174	No hit	No description
Gene3D	G3DSA:3.30.160.60	5.1E-20	131	165	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profile	PS50157	12.57	140	169	IPR007087	Zinc finger, C2H2
SMART	SM00355	4.4E-4	140	164	IPR015880	Zinc finger, C2H2-like
PROSITE pattern	PS00028	0	142	164	IPR007087	Zinc finger, C2H2
Gene3D	G3DSA:3.30.160.60	5.1E-8	166	196	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profile	PS50157	10.201	170	199	IPR007087	Zinc finger, C2H2
SMART	SM00355	0.023	170	194	IPR015880	Zinc finger, C2H2-like
PROSITE pattern	PS00028	0	172	195	IPR007087	Zinc finger, C2H2
SuperFamily	SSF57667	2.39E-5	232	263	No hit	No description
Gene3D	G3DSA:3.30.160.60	5.7E-7	234	263	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SMART	SM00355	0.043	240	265	IPR015880	Zinc finger, C2H2-like
PROSITE profile	PS50157	11.136	240	270	IPR007087	Zinc finger, C2H2
PROSITE pattern	PS00028	0	242	265	IPR007087	Zinc finger, C2H2

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0003676	Molecular Function	nucleic acid binding
GO:0046872	Molecular Function	metal ion binding

Sequence ? help Back to Top
Protein Sequence Length: 389 aa Download sequence Send to blast
MEHHSFHNLF ERRPIVNNKK SSKIPPVKWY KQWVPQDVVA TGGKCMVMKW VSEAQMKALK 60 QKKENPVTAE PEPEPTTEVL FLCSFEGCGK TFIDAGALKK HSNIHGERQH VCHYENCGKK 120 FLDSSKLKRH FLIHTGERDF ICPHEGCGKA FSLDFNLKSH MKTHSQENYH ICPFRECGKR 180 YAHEYKLKKH MMSHHEKNNM AELPSKYVNI QVQPVEKPPP RPPKMASTAT YTTPSYDRPY 240 ACPYDSCDKA YIHEYKLNLH LRREHPGHLP EENPKNTSRN KNNNNGDMDA GSDHDVYAVK 300 RGNTNSLKQN RPKPNIRLPP AKVAKHKPAP ASVAMPSVAK KQLWAGAKPV HEDEDSEETE 360 EDRDDDPEDG WRYRGNDNDD DDEETDYED

Sequence ? help Back to Top

Protein Sequence Length: 389 aa Download sequence Send to blast

MEHHSFHNLF ERRPIVNNKK SSKIPPVKWY KQWVPQDVVA TGGKCMVMKW VSEAQMKALK  60
QKKENPVTAE PEPEPTTEVL FLCSFEGCGK TFIDAGALKK HSNIHGERQH VCHYENCGKK  120
FLDSSKLKRH FLIHTGERDF ICPHEGCGKA FSLDFNLKSH MKTHSQENYH ICPFRECGKR  180
YAHEYKLKKH MMSHHEKNNM AELPSKYVNI QVQPVEKPPP RPPKMASTAT YTTPSYDRPY  240
ACPYDSCDKA YIHEYKLNLH LRREHPGHLP EENPKNTSRN KNNNNGDMDA GSDHDVYAVK  300
RGNTNSLKQN RPKPNIRLPP AKVAKHKPAP ASVAMPSVAK KQLWAGAKPV HEDEDSEETE  360
EDRDDDPEDG WRYRGNDNDD DDEETDYED

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1ubd_C	2e-33	83	199	8	122	PROTEIN (YY1 ZINC FINGER DOMAIN)
Search in ModeBase

Expression -- Description ? help Back to Top
Source	Description
Uniprot	DEVELOPMENTAL STAGE: Rapidly induced following seed germination, especially in tender cotyledons. {ECO:0000269\|PubMed:26961720}.
Uniprot	TISSUE SPECIFICITY: Mostly expressed in flowers, to a lower extent in seedlings, stems and leaves, and, at low levels, in roots and senescent leaves. {ECO:0000269\|PubMed:26961720}.

Functional Description ? help Back to Top
Source	Description
UniProt	Dual-function transcription factor with both repression and activation activities. Binds to 5'-CCATATT-3' motif in target gene promoters (e.g. ABR1) (PubMed:26961720). Binds also to G-rich DNA motif 5'-GGGGGCAGTGG-3' (PubMed:22508367). Regulates the expression of genes involved in diverse cellular pathways, including glucose metabolism, photosynthesis, phototropism and stress response (e.g. salt, drought and osmotic stress) (PubMed:22508367, PubMed:26961720). Regulates plant immunity, especially during necrotrophic fungal infection (e.g. B.cinerea) (PubMed:24451981). Binds to ABR1 promoter and promotes its expression, thus negatively regulating the abscisic acid (ABA) signaling pathway. Represses ABA- and salt-responsive genes expression (PubMed:26961720). {ECO:0000269\|PubMed:22508367, ECO:0000269\|PubMed:24451981, ECO:0000269\|PubMed:26961720}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Induced by abscisic acid (ABA) in an ABI1- and ABI4-dependent manner. Stimulated by stress conditions including high salt, osmotic stress (e.g. mannitol) and dehydration. May be induced by ABI4 but repressed by ABR1. Repressed by darkness but induced by light. {ECO:0000269\|PubMed:26961720}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_021976126.1	0.0	zinc finger transcription factor YY1 isoform X2
Swissprot	Q2V3L3	1e-134	YY1_ARATH; Zinc finger transcription factor YY1
TrEMBL	A0A2U1P3J6	0.0	A0A2U1P3J6_ARTAN; Zinc finger (C2H2 type) family protein
STRING	Migut.B00804.1.p	1e-153	(Erythranthe guttata)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT4G06634.1	1e-119	C2H2 family protein

Publications ? help Back to Top
Kumekawa N,Hosouchi T,Tsuruoka H,Kotani H The size and sequence organization of the centromeric region of Arabidopsis thaliana chromosome 4. DNA Res., 2001. 8(6): p. 285-90 [PMID:11853315] Li T,Wu XY,Li H,Song JH,Liu JY A Dual-Function Transcription Factor, AtYY1, Is a Novel Negative Regulator of the Arabidopsis ABA Response Network. Mol Plant, 2016. 9(5): p. 650-661 [PMID:26961720] Wu XY,Li T A Casein Kinase II Phosphorylation Site in AtYY1 Affects Its Activity, Stability, and Function in the ABA Response. Front Plant Sci, 2017. 8: p. 323 [PMID:28348572]