PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Aan002098
Organism
Artemisia annua
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae; Artemisiinae; Artemisia
Family C2H2
Protein Properties Length: 366aa    MW: 42817.1 Da    PI: 9.0227
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
gnl|UG|Aan#S41964316PU_unrefUnigeneView CDS
PUT-183a-Artemisia_annua-135961PU_refplantGDBView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H220.99.3e-076787323
               ETTTTEEESSHHHHHHHHHHT CS
    zf-C2H2  3 CpdCgksFsrksnLkrHirtH 23
               C+ Cg sF+ + +Lk+H+++H
  Aan002098 67 CEECGVSFKKPAHLKQHMQSH 87
               *******************99 PP
2zf-C2H218.55.6e-0693117123
                EEET..TTTEEESSHHHHHHHHHHT CS
    zf-C2H2   1 ykCp..dCgksFsrksnLkrHirtH 23 
                ++Cp  dC+ s++rk++L+rH+  H
  Aan002098  93 FTCPvkDCNLSYRRKDHLTRHLIHH 117
                89*******************9877 PP
3zf-C2H2163.4e-05122145323
                ET..TTTEEESSHHHHHHHHHH.T CS
    zf-C2H2   3 Cp..dCgksFsrksnLkrHirt.H 23 
                Cp  +C++ Fs++ +++rH +  H
  Aan002098 122 CPikKCTRKFSTQGDMERHVQEiH 145
                9999***************99877 PP
4zf-C2H217.61.1e-05157181123
                EEET..TTTEEESSHHHHHHHHHHT CS
    zf-C2H2   1 ykCp..dCgksFsrksnLkrHirtH 23 
                ++C    Cgk F+  s L++H ++H
  Aan002098 157 HVCLepGCGKAFRYASKLQKHENSH 181
                5788889***************999 PP
5zf-C2H214.78.8e-05249272323
                ET..TTTEEESSHHHHHHHHHH.T CS
    zf-C2H2   3 Cp..dCgksFsrksnLkrHirt.H 23 
                C    C+ +Fs++snL++H +  H
  Aan002098 249 CCfeECKLTFSNNSNLRQHVKAaH 272
                66689**************99877 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SMARTSM00355232144IPR015880Zinc finger, C2H2-like
SMARTSM003550.0496587IPR015880Zinc finger, C2H2-like
PROSITE profilePS5015713.4226592IPR007087Zinc finger, C2H2
SuperFamilySSF576672.24E-1066117No hitNo description
Gene3DG3DSA:3.30.160.603.5E-66783IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE patternPS0002806787IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.607.7E-1184117IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM003550.009493117IPR015880Zinc finger, C2H2-like
PROSITE profilePS501578.66393117IPR007087Zinc finger, C2H2
PROSITE patternPS00028095117IPR007087Zinc finger, C2H2
PROSITE profilePS501579.141120150IPR007087Zinc finger, C2H2
SMARTSM003550.02120145IPR015880Zinc finger, C2H2-like
PROSITE patternPS000280122145IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.608.0E-8150181IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamilySSF576674.48E-5153182No hitNo description
SMARTSM003550.013157181IPR015880Zinc finger, C2H2-like
PROSITE profilePS5015710.533157186IPR007087Zinc finger, C2H2
PROSITE patternPS000280159181IPR007087Zinc finger, C2H2
SMARTSM0035511189214IPR015880Zinc finger, C2H2-like
PROSITE patternPS000280191214IPR007087Zinc finger, C2H2
SMARTSM0035520217238IPR015880Zinc finger, C2H2-like
SuperFamilySSF576671.25E-8232286No hitNo description
PROSITE profilePS5015712.05247277IPR007087Zinc finger, C2H2
SMARTSM003550.6247272IPR015880Zinc finger, C2H2-like
PROSITE patternPS000280249272IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.608.5E-6252276IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
Gene3DG3DSA:3.30.160.601.1E-5277301IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM003553.1278304IPR015880Zinc finger, C2H2-like
PROSITE patternPS000280280304IPR007087Zinc finger, C2H2
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0003676Molecular Functionnucleic acid binding
GO:0046872Molecular Functionmetal ion binding
Sequence ? help Back to Top
Protein Sequence    Length: 366 aa     Download sequence    Send to blast
MELKTITKKK RVPKYRDIRR YACEYCGIIR SKKTLIKSHI HSNHQDEIKE KKDDREEAEN  60
GAKKKLCEEC GVSFKKPAHL KQHMQSHSLE RPFTCPVKDC NLSYRRKDHL TRHLIHHELL  120
NCPIKKCTRK FSTQGDMERH VQEIHDKADD KNDENKHVCL EPGCGKAFRY ASKLQKHENS  180
HVQLETVEAF CGELGCMKFF TNKQCLMAHL QTCHQYINCE ICGSKQLRKN IKRHLRTHEK  240
GVSKERIRCC FEECKLTFSN NSNLRQHVKA AHLQEKPFVC SFSDCGMRFA YKHVRDNHEK  300
TGRHVYTVGD FVEADAEFQS RPRGGTKRKL PAMIETLLKK RVLPPNESDC HDADYLSWLL  360
SGVEEE
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
2i13_A4e-135923816184Aart
2i13_B4e-135923816184Aart
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Both isoforms 1 and 2 transcripts are expressed in seedlings and both TFIIIA and TFIIIA-C are present at similar ratios in 10-day-old seedlings (at protein level). In correlation with the reorganization of 5S rDNA chromatin to a mature state, full-length isoform 1 protein TFIIIA with transcriptional activity accumulates and permits de novo transcription of 5S rRNA. Isoforms 1 and 2 transcripts accumulate in various tissues of the reproductive phase, including flowers and siliques, but only isoform 2 is present in mature seeds. In flowers, both TFIIIA and TFIIIA-C are present at similar ratios (at protein level). Very low amounts of TFIIIA are found in extracts from fresh siliques compared to TFIIIA-C. The amount of full-length TFIIIA protein progressively increases from fresh siliques to seeds concomitant with lower proportions of the shorter TFIIIA-C protein (at protein level) thus leading to 5S rRNA accumulation in the seed. {ECO:0000269|PubMed:22353599}.
UniprotTISSUE SPECIFICITY: Expressed in seedlings, flowers, siliques and seeds. {ECO:0000269|PubMed:22353599}.
Functional Description ? help Back to Top
Source Description
UniProtEssential protein (PubMed:22353599). Isoform 1 is a transcription activator the binds both 5S rDNA and 5S rRNA and stimulates the transcription of 5S rRNA gene (PubMed:12711688, PubMed:22353599). Isoform 1 regulates 5S rRNA levels during development (PubMed:22353599). {ECO:0000269|PubMed:12711688, ECO:0000269|PubMed:22353599}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_024988042.10.0transcription factor IIIA-like
SwissprotQ84MZ41e-128TF3A_ARATH; Transcription factor IIIA
TrEMBLA0A2U1QAH30.0A0A2U1QAH3_ARTAN; Zinc finger, C2H2
STRINGXP_010251838.11e-159(Nelumbo nucifera)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G72050.21e-124transcription factor IIIA