PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

MYB_related

Protein Properties

Length: 299aa MW: 33013.7 Da PI: 10.6057

Description

MYB_related family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT5G67580.2	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	Myb_DNA-binding	40.1	8.7e-13	5	55	1	46
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHT.....TTS-HHHHHHHHHH CS Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmg.....kgRtlkqcksrwqk 46 +++WT+eE+ l+ +v ++G+g W+tI + k R+ ++k++w++ AT5G67580.2 5 KQKWTPEEEAALKAGVLKHGTGKWRTILSDTEfslilKSRSNVDLKDKWRN 55 79***********************************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS51294	14.771	1	61	IPR017930	Myb domain
SuperFamily	SSF46689	1.64E-15	2	61	IPR009057	Homeodomain-like
SMART	SM00717	4.6E-7	4	59	IPR001005	SANT/Myb domain
Pfam	PF00249	2.4E-9	5	55	IPR001005	SANT/Myb domain
Gene3D	G3DSA:1.10.10.60	6.7E-14	5	56	IPR009057	Homeodomain-like
CDD	cd11660	1.11E-16	6	56	No hit	No description
SuperFamily	SSF46785	1.58E-15	118	201	IPR011991	Winged helix-turn-helix DNA-binding domain
Gene3D	G3DSA:1.10.10.10	1.0E-11	119	186	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM00526	8.6E-12	119	184	IPR005818	Linker histone H1/H5, domain H15
PROSITE profile	PS51504	18.977	121	189	IPR005818	Linker histone H1/H5, domain H15
Pfam	PF00538	5.7E-9	124	182	IPR005818	Linker histone H1/H5, domain H15

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006334	Biological Process	nucleosome assembly
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0009651	Biological Process	response to salt stress
GO:0009723	Biological Process	response to ethylene
GO:0009733	Biological Process	response to auxin
GO:0009737	Biological Process	response to abscisic acid
GO:0009739	Biological Process	response to gibberellin
GO:0009751	Biological Process	response to salicylic acid
GO:0009753	Biological Process	response to jasmonic acid
GO:0031627	Biological Process	telomeric loop formation
GO:0046686	Biological Process	response to cadmium ion
GO:0000784	Cellular Component	nuclear chromosome, telomeric region
GO:0000785	Cellular Component	chromatin
GO:0000786	Cellular Component	nucleosome
GO:0005730	Cellular Component	nucleolus
GO:0003691	Molecular Function	double-stranded telomeric DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0042803	Molecular Function	protein homodimerization activity
GO:0043047	Molecular Function	single-stranded telomeric DNA binding

Plant Ontology ? help Back to Top
PO Term	PO Category	PO Description
PO:0000013	anatomy	cauline leaf
PO:0000037	anatomy	shoot apex
PO:0000230	anatomy	inflorescence meristem
PO:0000293	anatomy	guard cell
PO:0008019	anatomy	leaf lamina base
PO:0009005	anatomy	root
PO:0009006	anatomy	shoot system
PO:0009009	anatomy	plant embryo
PO:0009010	anatomy	seed
PO:0009025	anatomy	vascular leaf
PO:0009029	anatomy	stamen
PO:0009030	anatomy	carpel
PO:0009031	anatomy	sepal
PO:0009032	anatomy	petal
PO:0009046	anatomy	flower
PO:0009047	anatomy	stem
PO:0009052	anatomy	flower pedicel
PO:0020030	anatomy	cotyledon
PO:0020038	anatomy	petiole
PO:0020100	anatomy	hypocotyl
PO:0020137	anatomy	leaf apex
PO:0025022	anatomy	collective leaf structure
PO:0025195	anatomy	pollen tube cell
PO:0025281	anatomy	pollen
PO:0001054	developmental stage	vascular leaf senescent stage
PO:0001078	developmental stage	plant embryo cotyledonary stage
PO:0001081	developmental stage	mature plant embryo stage
PO:0001185	developmental stage	plant embryo globular stage
PO:0004507	developmental stage	plant embryo bilateral stage
PO:0007064	developmental stage	LP.12 twelve leaves visible stage
PO:0007095	developmental stage	LP.08 eight leaves visible stage
PO:0007098	developmental stage	LP.02 two leaves visible stage
PO:0007103	developmental stage	LP.10 ten leaves visible stage
PO:0007115	developmental stage	LP.04 four leaves visible stage
PO:0007123	developmental stage	LP.06 six leaves visible stage
PO:0007131	developmental stage	seedling development stage
PO:0007611	developmental stage	petal differentiation and expansion stage
PO:0007616	developmental stage	flowering stage

Sequence ? help Back to Top
Protein Sequence Length: 299 aa Download sequence Send to blast
MGAPKQKWTP EEEAALKAGV LKHGTGKWRT ILSDTEFSLI LKSRSNVDLK DKWRNISVTA 60 LWGSRKKAKL ALKRTPPGTK QDDNNTALTI VALTNDDERA KPTSPGGSGG GSPRTCASKR 120 SITSLDKIIF EAITNLRELR GSDRTSIFLY IEENFKTPPN MKRHVAVRLK HLSSNGTLVK 180 IKHKYRFSSN FIPAGARQKA PQLFLEGNNK KDPTKPEENG ANSLTKFRVD GELYMIKGMT 240 AQEAAEAAAR AVAEAEFAIT EAEQAAKEAE RAEAEAEAAQ IFAKAAMKAL KFRIRNHPW

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
At.7636	0.0	bud\| root

Expression -- Microarray ? help Back to Top
Source	ID	E-value
GEO	145362097	0.0
Genevisible	247012_at	0.0
Expression Atlas	AT5G67580	-
AtGenExpress	AT5G67580	-
ATTED-II	AT5G67580	-

Expression -- Description ? help Back to Top
Source	Description
Uniprot	TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269\|PubMed:15060584}.

Functional Description ? help Back to Top
Source	Description
TAIR	Encodes a telomeric DNA binding protein. In vitro, the protein preferentially binds double-stranded telomeric repeats, but it can also bind to the single G-rich telomeric strand.
UniProt	Binds preferentially double-stranded telomeric repeats, but it can also bind to the single G-rich telomeric strand.

Function -- GeneRIF ? help Back to Top
structure and function of AtTRB2 protein [PMID: 22859734] Trp28, Arg29, and Val47 residues located in Helix 2 and Helix 3 of TRB2 are crucial for DNA binding, and are well conserved among other plant telomere binding proteins. [PMID: 25172657] TRB2 interacts with HD2-type histone deacetylase HDT4.TRB2 has a role in the regulation of telomeric chromatin. [PMID: 26857545]

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00597	DAP	27203113	Download

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT5G67580.2

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Regulation -- Hormone ? help Back to Top
Source	Hormone
AHD	abscisic acid, auxin, ethylene, gibberellin, jasmonic acid, salicylic acid

Interaction -- BIND ? help Back to Top
Source	Intact With	Description
BIND	AT1G49950	TRB1 interacts with TRB2.
BIND	AT5G67580	TRB2 interacts with another molecule of TRB2.

Interaction ? help Back to Top
Source	Intact With
BioGRID	AT5G67580, AT1G49950
IntAct	Search Q9FJW5

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT5G67580

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AY039883	0.0	AY039883.1 Arabidopsis thaliana AT5g67580/K9I9_15 mRNA, complete cds.
GenBank	AY077668	0.0	AY077668.1 Arabidopsis thaliana AT5g67580/K9I9_15 mRNA, complete cds.
GenBank	AY519545	0.0	AY519545.1 Arabidopsis thaliana MYB transcription factor (At5g67580) mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_201559.1	0.0	Homeodomain-like/winged-helix DNA-binding family protein
Refseq	NP_851286.1	0.0	Homeodomain-like/winged-helix DNA-binding family protein
Swissprot	Q9FJW5	0.0	TRB2_ARATH; Telomere repeat-binding factor 2
TrEMBL	A0A178UR21	0.0	A0A178UR21_ARATH; TRB2
STRING	AT5G67580.1	0.0	(Arabidopsis thaliana)

Link Out ? help Back to Top
Phytozome	AT5G67580.2
Entrez Gene	836894
iHOP	AT5G67580
wikigenes	AT5G67580

Publications ? help Back to Top
Riechmann JL, et al. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] Marian CO, et al. The maize Single myb histone 1 gene, Smh1, belongs to a novel gene family and encodes a protein that binds telomere DNA repeats in vitro. Plant Physiol., 2003. 133(3): p. 1336-50 [PMID:14576282] Yamada K, et al. Empirical analysis of transcriptional activity in the Arabidopsis genome. Science, 2003. 302(5646): p. 842-6 [PMID:14593172] Schrumpfová P, et al. Characterization of two Arabidopsis thaliana myb-like proteins showing affinity to telomeric DNA sequence. Genome, 2004. 47(2): p. 316-24 [PMID:15060584] Wierzbicki AT,Jerzmanowski A Suppression of histone H1 genes in Arabidopsis results in heritable developmental defects and stochastic changes in DNA methylation. Genetics, 2005. 169(2): p. 997-1008 [PMID:15489532] Sottosanto JB,Gelli A,Blumwald E DNA array analyses of Arabidopsis thaliana lacking a vacuolar Na+/H+ antiporter: impact of AtNHX1 on gene expression. Plant J., 2004. 40(5): p. 752-71 [PMID:15546358] Kuchar M,Fajkus J Interactions of putative telomere-binding proteins in Arabidopsis thaliana: identification of functional TRF2 homolog in plants. FEBS Lett., 2004. 578(3): p. 311-5 [PMID:15589838] Yanhui C, et al. The MYB transcription factor superfamily of Arabidopsis: expression analysis and phylogenetic comparison with the rice MYB family. Plant Mol. Biol., 2006. 60(1): p. 107-24 [PMID:16463103] Sottosanto JB,Saranga Y,Blumwald E Impact of AtNHX1, a vacuolar Na+/H+ antiporter, upon gene expression during short- and long-term salt stress in Arabidopsis thaliana. BMC Plant Biol., 2007. 7: p. 18 [PMID:17411438] Schrumpfov Mapping of interaction domains of putative telomere-binding proteins AtTRB1 and AtPOT1b from Arabidopsis thaliana. FEBS Lett., 2008. 582(10): p. 1400-6 [PMID:18387366] Chi W, et al. The pentratricopeptide repeat protein DELAYED GREENING1 is involved in the regulation of early chloroplast development and chloroplast gene expression in Arabidopsis. Plant Physiol., 2008. 147(2): p. 573-84 [PMID:18400937] Ascencio-Ib Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection. Plant Physiol., 2008. 148(1): p. 436-54 [PMID:18650403] Wang Y, et al. Transcriptome analyses show changes in gene expression to accompany pollen germination and tube growth in Arabidopsis. Plant Physiol., 2008. 148(3): p. 1201-11 [PMID:18775970] Dvorácková M, et al. AtTRB1, a telomeric DNA-binding protein from Arabidopsis, is concentrated in the nucleolus and shows highly dynamic association with chromatin. Plant J., 2010. 61(4): p. 637-49 [PMID:19947985] Arabidopsis Interactome Mapping Consortium Evidence for network evolution in an Arabidopsis interactome map. Science, 2011. 333(6042): p. 601-7 [PMID:21798944] Lee WK,Yun JH,Lee W,Cho MH DNA-binding domain of AtTRB2 reveals unique features of a single Myb histone protein family that binds to both Arabidopsis- and human-type telomeric DNA sequences. Mol Plant, 2012. 5(6): p. 1406-8 [PMID:22859734] Yun JH, et al. Solution structure of telomere binding domain of AtTRB2 derived from Arabidopsis thaliana. Biochem. Biophys. Res. Commun., 2014. 452(3): p. 436-42 [PMID:25172657] Lee WK,Cho MH Telomere-binding protein regulates the chromosome ends through the interaction with histone deacetylases in Arabidopsis thaliana. Nucleic Acids Res., 2016. 44(10): p. 4610-24 [PMID:26857545] Kotliński M, et al. Phylogeny-Based Systematization of Arabidopsis Proteins with Histone H1 Globular Domain. Plant Physiol., 2017. 174(1): p. 27-34 [PMID:28298478]