|
Plant Transcription
Factor Database
|
Transcription Factor Information
Basic
Information? help
Back to Top |
TF ID |
AT5G11510.2 |
Common Name | AtMYB3R4, MYB3R-4 |
Organism |
|
Taxonomic ID |
|
Taxonomic Lineage |
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
|
Family |
MYB |
Protein Properties |
Length: 798aa MW: 90418.8 Da PI: 6.1778 |
Description |
myb domain protein 3r-4 |
Gene Model |
|
Signature Domain? help Back to Top |
|
No. |
Domain |
Score |
E-value |
Start |
End |
HMM Start |
HMM End |
1 | Myb_DNA-binding | 58.7 | 1.3e-18 | 29 | 75 | 1 | 48 |
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHHHT CS
Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqkyl 48
rg WT+eEde+l +av+ + g++Wk+Ia+++ Rt+ qc +rwqk+l
AT5G11510.2 29 RGQWTAEEDEILRKAVHSFKGKNWKKIAEYFK-DRTDVQCLHRWQKVL 75
89*****************************9.************986 PP
|
2 | Myb_DNA-binding | 62.9 | 6.3e-20 | 81 | 127 | 1 | 48 |
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHHHT CS
Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqkyl 48
+g+WT+eEde +v++++++G++ W+tIar ++ gR +kqc++rw+++l
AT5G11510.2 81 KGPWTKEEDEMIVQLIEKYGPKKWSTIARFLP-GRIGKQCRERWHNHL 127
79******************************.*************97 PP
|
3 | Myb_DNA-binding | 45.8 | 1.4e-14 | 133 | 175 | 1 | 45 |
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHH CS
Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwq 45
+ +WT+eE++ll++a++ +G++ W+ + ++ gR+++ +k++w+
AT5G11510.2 133 KEAWTQEEELLLIRAHQIYGNR-WAELTKFLP-GRSDNGIKNHWH 175
579*******************.*********.***********8 PP
|
Gene Ontology ? help Back to Top |
GO Term |
GO Category |
GO Description |
GO:0006355 | Biological Process | regulation of transcription, DNA-templated |
GO:0006357 | Biological Process | regulation of transcription from RNA polymerase II promoter |
GO:0030154 | Biological Process | cell differentiation |
GO:0032875 | Biological Process | regulation of DNA endoreduplication |
GO:0005634 | Cellular Component | nucleus |
GO:0000981 | Molecular Function | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
GO:0001135 | Molecular Function | transcription factor activity, RNA polymerase II transcription factor recruiting |
GO:0003713 | Molecular Function | transcription coactivator activity |
GO:0043565 | Molecular Function | sequence-specific DNA binding |
GO:0044212 | Molecular Function | transcription regulatory region DNA binding |
Sequence ? help Back to Top |
Protein Sequence Length: 798 aa
Download sequence Send
to blast |
MEAESSTPQE RIPKLRHGRT SGPARRSTRG QWTAEEDEIL RKAVHSFKGK NWKKIAEYFK 60 DRTDVQCLHR WQKVLNPELV KGPWTKEEDE MIVQLIEKYG PKKWSTIARF LPGRIGKQCR 120 ERWHNHLNPA INKEAWTQEE ELLLIRAHQI YGNRWAELTK FLPGRSDNGI KNHWHSSVKK 180 KLDSYMSSGL LDQYQAMPLA PYERSSTLQS TFMQSNIDGN GCLNGQAENE IDSRQNSSMV 240 GCSLSARDFQ NGTINIGHDF HPCGNSQENE QTAYHSEQFY YPELEDISVS ISEVSYDMED 300 CSQFPDHNVS TSPSQDYQFD FQELSDISLE MRHNMSEIPM PYTKESKEST LGAPNSTLNI 360 DVATYTNSAN VLTPETECCR VLFPDQESEG HSVSRSLTQE PNEFNQVDRR DPILYSSASD 420 RQISEATKSP TQSSSSRFTA TAASGKGTLR PAPLIISPDK YSKKSSGLIC HPFEVEPKCT 480 TNGNGSFICI GDPSSSTCVD EGTNNSSEED QSYHVNDPKK LVPVNDFASL AEDRPHSLPK 540 HEPNMTNEQH HEDMGASSSL GFPSFDLPVF NCDLLQSKND PLHDYSPLGI RKLLMSTMTC 600 MSPLRLWESP TGKKTLVGAQ SILRKRTRDL LTPLSEKRSD KKLEIDIAAS LAKDFSRLDV 660 MFDETENRQS NFGNSTGVIH GDRENHFHIL NGDGEEWSGK PSSLFSHRMP EETMHIRKSL 720 EKVDQICMEA NVREKDDSEQ DVENVSLFLS FNHLNISCAT GLHKLSSFRF CRQSCHFVTC 780 VKIFIVLVSF NRHCSNRL
|
Expression --
Description ? help
Back to Top |
Source |
Description |
Uniprot | DEVELOPMENTAL STAGE: Expressed in the root quiescent center (PubMed:15937229). Accumulates in division zone of primary root tips and emerging lateral roots. Also present in floral organs in young flower buds. Weakly and uniformly present in the developing embryo and maternal tissues (PubMed:17287251). Expressed specifically in proliferating stage of leaves (PubMed:26069325). {ECO:0000269|PubMed:15937229, ECO:0000269|PubMed:17287251, ECO:0000269|PubMed:26069325}. |
Uniprot | TISSUE SPECIFICITY: Expressed in roots, cotyledons and leaves, especially in vascular tissues, and in flowers. {ECO:0000269|PubMed:17287251}. |
Functional Description ? help
Back to Top |
Source |
Description |
TAIR | Arabidopsis thaliana putative c-myb-like transcription factor MYB3R-4. Functions in powdery mildew induced host endoreduplication at the site of infection. |
UniProt | Transcription factor that binds 5'-AACGG-3' motifs in gene promoters (PubMed:21862669). Involved in the regulation of cytokinesis, probably via the activation of several G2/M phase-specific genes transcription (e.g. KNOLLE) (PubMed:17287251, PubMed:21862669, PubMed:25806785). Required for the maintenance of diploidy (PubMed:21862669). {ECO:0000269|PubMed:17287251, ECO:0000269|PubMed:21862669, ECO:0000269|PubMed:25806785}.; FUNCTION: Involved in transcription regulation during induced endoreduplication at the powdery mildew (e.g. G.orontii) infection site, thus promoting G.orontii growth and reproduction. {ECO:0000269|PubMed:20018666}. |
Function -- GeneRIF ? help
Back to Top |
- Our results suggest that a pair of structurally related myb3r1 myb3r4 transcription factors may positively regulate cytokinesis mainly through transcriptional activation of the KN gene.
[PMID: 17287251] - MYB3R1 and MYB3R4 may have diverse roles during plant development by regulating G2/M-specific genes with various functions as well as genes possibly unrelated to the cell cycle.
[PMID: 21862669]
|
Regulation -- Description ? help
Back to Top |
Source |
Description |
UniProt | INDUCTION: Slightly induced by salicylic acid (SA) (PubMed:16463103). Expressed in a cell cycle-dependent manner, with highest levels 2 hours before the peak of mitotic index in cells synchronized by aphidicolin. Activated by CYCB1 (PubMed:17287251). Accumulates at powdery mildew (e.g. G.orontii) infected cells. {ECO:0000269|PubMed:16463103, ECO:0000269|PubMed:17287251}. |
Annotation --
Nucleotide ? help
Back to Top |
Source |
Hit ID |
E-value |
Description |
GenBank | AF371975 | 0.0 | AF371975.2 Arabidopsis thaliana putative c-myb-like transcription factor MYB3R-4 (MYB3R4) mRNA, complete cds. |
GenBank | AY519650 | 0.0 | AY519650.1 Arabidopsis thaliana MYB transcription factor (At5g11510) mRNA, complete cds. |
Publications
? help Back to Top |
- Riechmann JL, et al.
Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] - Stracke R,Werber M,Weisshaar B
The R2R3-MYB gene family in Arabidopsis thaliana. Curr. Opin. Plant Biol., 2001. 4(5): p. 447-56 [PMID:11597504] - Menges M,de Jager SM,Gruissem W,Murray JA
Global analysis of the core cell cycle regulators of Arabidopsis identifies novel genes, reveals multiple and highly specific profiles of expression and provides a coherent model for plant cell cycle control. Plant J., 2005. 41(4): p. 546-66 [PMID:15686519] - Pina C,Pinto F,Feij
Gene family analysis of the Arabidopsis pollen transcriptome reveals biological implications for cell growth, division control, and gene expression regulation. Plant Physiol., 2005. 138(2): p. 744-56 [PMID:15908605] - Nawy T, et al.
Transcriptional profile of the Arabidopsis root quiescent center. Plant Cell, 2005. 17(7): p. 1908-25 [PMID:15937229] - Duarte JM, et al.
Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis. Mol. Biol. Evol., 2006. 23(2): p. 469-78 [PMID:16280546] - Yanhui C, et al.
The MYB transcription factor superfamily of Arabidopsis: expression analysis and phylogenetic comparison with the rice MYB family. Plant Mol. Biol., 2006. 60(1): p. 107-24 [PMID:16463103] - Okada T,Bhalla PL,Singh MB
Expressed sequence tag analysis of Lilium longiflorum generative cells. Plant Cell Physiol., 2006. 47(6): p. 698-705 [PMID:16571618] - Haga N, et al.
R1R2R3-Myb proteins positively regulate cytokinesis through activation of KNOLLE transcription in Arabidopsis thaliana. Development, 2007. 134(6): p. 1101-10 [PMID:17287251] - L
Distinct light-initiated gene expression and cell cycle programs in the shoot apex and cotyledons of Arabidopsis. Plant Cell, 2008. 20(4): p. 947-68 [PMID:18424613] - Day RC,Herridge RP,Ambrose BA,Macknight RC
Transcriptome analysis of proliferating Arabidopsis endosperm reveals biological implications for the control of syncytial division, cytokinin signaling, and gene expression regulation. Plant Physiol., 2008. 148(4): p. 1964-84 [PMID:18923020] - Ma Q, et al.
Enhanced tolerance to chilling stress in OsMYB3R-2 transgenic rice is mediated by alteration in cell cycle and ectopic expression of stress genes. Plant Physiol., 2009. 150(1): p. 244-56 [PMID:19279197] - Chandran D,Inada N,Hather G,Kleindt CK,Wildermuth MC
Laser microdissection of Arabidopsis cells at the powdery mildew infection site reveals site-specific processes and regulators. Proc. Natl. Acad. Sci. U.S.A., 2010. 107(1): p. 460-5 [PMID:20018666] - Haga N, et al.
Mutations in MYB3R1 and MYB3R4 cause pleiotropic developmental defects and preferential down-regulation of multiple G2/M-specific genes in Arabidopsis. Plant Physiol., 2011. 157(2): p. 706-17 [PMID:21862669] - Jin J, et al.
An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors. Mol. Biol. Evol., 2015. 32(7): p. 1767-73 [PMID:25750178] - Saito T, et al.
Genetic interaction between G2/M phase-specific transcription factor MYB3R4 and MAPKKK ANP3 for execution of cytokinesis in Arabidopsis thaliana. Plant Signal Behav, 2015. 10(3): p. e990817 [PMID:25806785] - Kobayashi K, et al.
Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325] - Chen P, et al.
Arabidopsis R1R2R3-Myb proteins are essential for inhibiting cell division in response to DNA damage. Nat Commun, 2017. 8(1): p. 635 [PMID:28935922]
|