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Plant Transcription
Factor Database
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Transcription Factor Information
Basic
Information? help
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TF ID |
AT5G05660.1 |
Common Name | ATNFXL2, EBI, MJJ3.6, NFXL2 |
Organism |
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Taxonomic ID |
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Taxonomic Lineage |
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
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Family |
NF-X1 |
Protein Properties |
Length: 880aa MW: 98882.3 Da PI: 8.3072 |
Description |
sequence-specific DNA binding transcription factors;zinc ion binding;sequence-specific DNA binding transcription factors |
Gene Model |
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Signature Domain? help Back to Top |
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No. |
Domain |
Score |
E-value |
Start |
End |
HMM Start |
HMM End |
1 | zf-NF-X1 | 16.4 | 2e-05 | 247 | 266 | 1 | 20 |
zf-NF-X1 1 CGkHkCqklCHeGpCppCpq 20
C +H C ++CH G+CppC++
AT5G05660.1 247 CNIHNCREICHDGECPPCRE 266
449***************85 PP
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2 | zf-NF-X1 | 16.5 | 1.8e-05 | 354 | 373 | 1 | 19 |
zf-NF-X1 1 CGkHkCqklCHeGpCpp.Cp 19
CG H+C + CH+GpC + C+
AT5G05660.1 354 CGYHRCPERCHRGPCLEtCR 373
*****************997 PP
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3 | zf-NF-X1 | 17.7 | 7.7e-06 | 428 | 452 | 1 | 19 |
zf-NF-X1 1 CG......kHkCqklCHeGpCppCp 19
CG +HkCq++CH GpC pCp
AT5G05660.1 428 CGkklrcrNHKCQSPCHQGPCAPCP 452
777777779***************9 PP
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Protein Features
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Database |
Entry ID |
E-value |
Start |
End |
InterPro ID |
Description |
PROSITE pattern | PS01359 | 0 | 84 | 148 | IPR019786 | Zinc finger, PHD-type, conserved site |
CDD | cd06008 | 8.27E-5 | 183 | 231 | No hit | No description |
SMART | SM00438 | 8.1 | 195 | 213 | IPR000967 | Zinc finger, NF-X1-type |
Pfam | PF01422 | 2.5 | 195 | 212 | IPR000967 | Zinc finger, NF-X1-type |
CDD | cd06008 | 5.05E-9 | 237 | 285 | No hit | No description |
SMART | SM00438 | 3.5E-4 | 247 | 266 | IPR000967 | Zinc finger, NF-X1-type |
Pfam | PF01422 | 5.0E-4 | 247 | 265 | IPR000967 | Zinc finger, NF-X1-type |
CDD | cd06008 | 8.02E-7 | 290 | 330 | No hit | No description |
SMART | SM00438 | 0.05 | 300 | 319 | IPR000967 | Zinc finger, NF-X1-type |
Pfam | PF01422 | 0.064 | 300 | 318 | IPR000967 | Zinc finger, NF-X1-type |
CDD | cd06008 | 2.18E-9 | 344 | 393 | No hit | No description |
SMART | SM00438 | 0.035 | 354 | 374 | IPR000967 | Zinc finger, NF-X1-type |
Pfam | PF01422 | 0.0013 | 354 | 373 | IPR000967 | Zinc finger, NF-X1-type |
CDD | cd06008 | 1.05E-6 | 397 | 445 | No hit | No description |
SMART | SM00438 | 0.33 | 407 | 426 | IPR000967 | Zinc finger, NF-X1-type |
Pfam | PF01422 | 0.036 | 407 | 425 | IPR000967 | Zinc finger, NF-X1-type |
CDD | cd06008 | 5.05E-11 | 424 | 472 | No hit | No description |
Pfam | PF01422 | 7.0E-4 | 428 | 452 | IPR000967 | Zinc finger, NF-X1-type |
SMART | SM00438 | 0.0034 | 434 | 453 | IPR000967 | Zinc finger, NF-X1-type |
SMART | SM00438 | 76 | 491 | 512 | IPR000967 | Zinc finger, NF-X1-type |
Pfam | PF01422 | 4.8 | 501 | 511 | IPR000967 | Zinc finger, NF-X1-type |
SMART | SM00438 | 220 | 520 | 565 | IPR000967 | Zinc finger, NF-X1-type |
Pfam | PF01422 | 76 | 520 | 529 | IPR000967 | Zinc finger, NF-X1-type |
SMART | SM00438 | 33 | 602 | 633 | IPR000967 | Zinc finger, NF-X1-type |
Pfam | PF01422 | 0.45 | 602 | 612 | IPR000967 | Zinc finger, NF-X1-type |
SMART | SM00438 | 0.41 | 643 | 661 | IPR000967 | Zinc finger, NF-X1-type |
Pfam | PF01422 | 17 | 644 | 660 | IPR000967 | Zinc finger, NF-X1-type |
SMART | SM00438 | 48 | 706 | 735 | IPR000967 | Zinc finger, NF-X1-type |
Pfam | PF01422 | 6.9 | 708 | 720 | IPR000967 | Zinc finger, NF-X1-type |
Gene Ontology ? help Back to Top |
GO Term |
GO Category |
GO Description |
GO:0000122 | Biological Process | negative regulation of transcription from RNA polymerase II promoter |
GO:0007623 | Biological Process | circadian rhythm |
GO:0009651 | Biological Process | response to salt stress |
GO:0009908 | Biological Process | flower development |
GO:0010310 | Biological Process | regulation of hydrogen peroxide metabolic process |
GO:0016567 | Biological Process | protein ubiquitination |
GO:0042335 | Biological Process | cuticle development |
GO:0045892 | Biological Process | negative regulation of transcription, DNA-templated |
GO:0045893 | Biological Process | positive regulation of transcription, DNA-templated |
GO:2000037 | Biological Process | regulation of stomatal complex patterning |
GO:0005634 | Cellular Component | nucleus |
GO:0016021 | Cellular Component | integral component of membrane |
GO:0000977 | Molecular Function | RNA polymerase II regulatory region sequence-specific DNA binding |
GO:0000987 | Molecular Function | core promoter proximal region sequence-specific DNA binding |
GO:0001078 | Molecular Function | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding |
GO:0008270 | Molecular Function | zinc ion binding |
GO:0016874 | Molecular Function | ligase activity |
Sequence ? help Back to Top |
Protein Sequence Length: 880 aa
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MAGTATTEFR WKSPPQPPSQ EQPISDSDSD SGSDSENHQH RHNDLSNSIF EAYLDCHSSS 60 SPSSIDLAKI QSFLASSSSG AVSCLICLER IKRTDPTWSC TSSCFAVFHL FCIQSWARQC 120 LDLQAARAVT RPSSNPTEPE AVWNCPKCRS SYQKSKIPRR YLCYCGKEED PPADNPWILP 180 HSCGEVCERP LSNNCGHCCL LLCHPGPCAS CPKLVKAKCF CGGVEDVRRC GHKQFSCGDV 240 CERVLDCNIH NCREICHDGE CPPCRERAVY KCSCGKVKEE KDCCERVFRC EASCENMLNC 300 GKHVCERGCH AGECGLCPYQ GKRSCPCGKR FYQGLSCDVV APLCGGTCDK VLGCGYHRCP 360 ERCHRGPCLE TCRIVVTKSC RCGVTKKQVP CHQELACERK CQRVRDCARH ACRRRCCDGE 420 CPPCSEICGK KLRCRNHKCQ SPCHQGPCAP CPIMVTISCA CGETHFEVPC GTETNQKPPR 480 CRKLCHITPL CRHGQNQKPH KCHYGACPPC RLLCDEEYPC GHKCKLRCHG PRPPPNREFI 540 LKPTKKMLHI QAESTPGSPC PRCPEPVWRP CVGHHLAAEK RMICSDRTQF ACDNLCGNPL 600 PCGNHYCSYF CHALDIRSSS LDKRSESCEK CDLRCQKERT PRCQHPCPRR CHPEDCPPCK 660 TLVKRSCHCG AMVHAFECIY YNTMSEKDQM KARSCRGPCH RKLPNCTHLC PEICHPGQCP 720 LPEKCGKKVV VRCKCLTLKK EWVCQDVQAA HRATGSDPKE VPKNQFGVGL LPCDSNCKSK 780 LQVAESVLTQ RNVKEIEEKE EPSGKNASKR RKRRGRGQDI QETTRLQKLA VTTKRILMVV 840 MLVAMLAAVS YYGYKGLLWL SDWMNEVEEQ RQKSRRYPRI
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Expression --
Description ? help
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Source |
Description |
Uniprot | TISSUE SPECIFICITY: Constitutively expressed in mesophyll and guard cells. {ECO:0000269|PubMed:22073231}. |
Functional Description ? help
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Source |
Description |
TAIR | Encodes a homolog of the mammalian zinc finger transcription factor NF-X1. |
UniProt | Probable transcriptional regulator. May mediate E2- or E3-dependent ubiquitination. Required to gate light sensitivity during the night. Regulates the speed of the clock by acting in the feedback loop between CCA1, LHY and APRR1/TOC1. Promotes the expression of CCA1 at night but not by days. This activational effect is enhanced by interaction with ADO1/ZTL. Association with ADO1/ZTL is not leading to the degradation of NFXL2. Confers sensitivity to osmotic stress such as high salinity. Prevents H(2)O(2) production and abscisic acid accumulation. Part of a regulatory network that integrates the biosynthesis and action of abscisic acid, reactive oxygen species and cuticle components. {ECO:0000269|PubMed:16905136, ECO:0000269|PubMed:21300918, ECO:0000269|PubMed:21429190, ECO:0000269|PubMed:22073231, ECO:0000269|PubMed:22516817}. |
Function -- GeneRIF ? help
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- The ebi-1 mutation alters the expression of core circadian clock components, and the ebi-1 mutant is early flowering.
[PMID: 21300918] - NFXL2-78 protein is part of a regulatory network that integrates the biosynthesis and action of ABA, ROS, and cuticle components. [NFX1-LIKE2] [NFXL2]
[PMID: 22516817]
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Regulation -- Description ? help
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Source |
Description |
UniProt | INDUCTION: Circadian-regulation with a peak of expression at or before dawn. Not regulated by biotic and abiotic stresses, by light and nutrient conditions or upon treatment with elicitors, chemicals, abscisic acid or phytohormones. {ECO:0000269|PubMed:21300918, ECO:0000269|PubMed:22073231}. |
Phenotype -- Disruption Phenotype ? help
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Source |
Description |
UniProt | DISRUPTION PHENOTYPE: No obvious morphological alterations. Enhanced growth and survival under water or salt stress. Enhanced H(2)O(2) production. Elevated abscisic acid levels and reduced stomatal aperture. {ECO:0000269|PubMed:16905136, ECO:0000269|PubMed:22073231}. |
Annotation --
Nucleotide ? help
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Source |
Hit ID |
E-value |
Description |
GenBank | AK228690 | 0.0 | AK228690.1 Arabidopsis thaliana mRNA for hypothetical protein, clone: RAFL16-04-K08. |
Publications
? help Back to Top |
- Lisso J,Altmann T,Müssig C
The AtNFXL1 gene encodes a NF-X1 type zinc finger protein required for growth under salt stress. FEBS Lett., 2006. 580(20): p. 4851-6 [PMID:16905136] - Wang Y, et al.
Transcriptome analyses show changes in gene expression to accompany pollen germination and tube growth in Arabidopsis. Plant Physiol., 2008. 148(3): p. 1201-11 [PMID:18775970] - M
Structure and putative function of NFX1-like proteins in plants. Plant Biol (Stuttg), 2010. 12(3): p. 381-94 [PMID:20522174] - Johansson M, et al.
Partners in time: EARLY BIRD associates with ZEITLUPE and regulates the speed of the Arabidopsis clock. Plant Physiol., 2011. 155(4): p. 2108-22 [PMID:21300918] - Ashelford K, et al.
Full genome re-sequencing reveals a novel circadian clock mutation in Arabidopsis. Genome Biol., 2011. 12(3): p. R28 [PMID:21429190] - Lisso J,Schr
NFX1-LIKE2 (NFXL2) suppresses abscisic acid accumulation and stomatal closure in Arabidopsis thaliana. PLoS ONE, 2011. 6(11): p. e26982 [PMID:22073231] - Lisso J,Schr
NFXL2 modifies cuticle properties in Arabidopsis. Plant Signal Behav, 2012. 7(5): p. 551-5 [PMID:22516817]
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