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Plant Transcription
Factor Database
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Transcription Factor Information
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Basic
Information? help
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| TF ID |
AT5G04410.1 |
| Common Name | anac078, NAC078, NAC2, NTL11, T32M21.10 |
| Organism |
|
| Taxonomic ID |
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| Taxonomic Lineage |
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
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| Family |
NAC |
| Protein Properties |
Length: 567aa MW: 63510.7 Da PI: 4.3837 |
| Description |
NAC domain containing protein 2 |
| Gene Model |
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| Signature Domain? help Back to Top |
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| No. |
Domain |
Score |
E-value |
Start |
End |
HMM Start |
HMM End |
| 1 | NAM | 171.6 | 2.3e-53 | 9 | 136 | 1 | 128 |
NAM 1 lppGfrFhPtdeelvveyLkkkvegkkleleevikevdiykvePwdLp.k.kvkaeekewyfFskrdkkyatgkrknratksgyWkatgkdkevlskk 96
l+pGfrFhPtdeelv +yLk+kv +k++++ ++i+ +diyk+ePwdLp k k+k+++ ewyfFs dkky++g+++nrat++gyWk+tgkd+e+ + +
AT5G04410.1 9 LAPGFRFHPTDEELVRYYLKRKVCNKPFKF-DAISVTDIYKSEPWDLPdKsKLKSRDLEWYFFSMLDKKYSNGSKTNRATEKGYWKTTGKDREIRN-G 104
579**************************9.99**************95347777888*************************************9.9 PP
NAM 97 gelvglkktLvfykgrapkgektdWvmheyrl 128
+++vg+kktLv++kgrap+ge+t+Wvmheyrl
AT5G04410.1 105 SRVVGMKKTLVYHKGRAPRGERTNWVMHEYRL 136
******************************98 PP
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| Gene Ontology ? help Back to Top |
| GO Term |
GO Category |
GO Description |
| GO:0007275 | Biological Process | multicellular organism development |
| GO:0009644 | Biological Process | response to high light intensity |
| GO:0009962 | Biological Process | regulation of flavonoid biosynthetic process |
| GO:0045893 | Biological Process | positive regulation of transcription, DNA-templated |
| GO:0005634 | Cellular Component | nucleus |
| GO:0005737 | Cellular Component | cytoplasm |
| GO:0016021 | Cellular Component | integral component of membrane |
| GO:0003677 | Molecular Function | DNA binding |
| GO:0003700 | Molecular Function | transcription factor activity, sequence-specific DNA binding |
| Sequence ? help Back to Top |
| Protein Sequence Length: 567 aa
Download sequence Send
to blast |
MGRGSVTSLA PGFRFHPTDE ELVRYYLKRK VCNKPFKFDA ISVTDIYKSE PWDLPDKSKL 60
KSRDLEWYFF SMLDKKYSNG SKTNRATEKG YWKTTGKDRE IRNGSRVVGM KKTLVYHKGR 120
APRGERTNWV MHEYRLSDED LKKAGVPQEA YVLCRIFQKS GTGPKNGEQY GAPYLEEEWE 180
EDGMTYVPAQ DAFSEGLALN DDVYVDIDDI DEKPENLVVY DAVPILPNYC HGESSNNVES 240
GNYSDSGNYI QPGNNVVDSG GYFEQPIETF EEDRKPIIRE GSIQPCSLFP EEQIGCGVQD 300
ENVVNLESSN NNVFVADTCY SDIPIDHNYL PDEPFMDPNN NLPLNDGLYL ETNDLSCAQQ 360
DDFNFEDYLS FFDDEGLTFD DSLLMGPEDF LPNQEALDQK PAPKELEKEV AGGKEAVEEK 420
ESGEGSSSKQ DTDFKDFDSA PKYPFLKKTS HMLGAIPTPS SFASQFQTKD AMRLHAAQSS 480
GSVHVTAGMM RISNMTLAAD SGMGWSYDKN GNLNVVLSFG VVQQDDAMTA SGSKTGITAT 540
RAMLVFMCLW VLLLSVSFKI VTMVSAR
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| 3D Structure ? help Back to Top |
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| PDB ID |
Evalue |
Query Start |
Query End |
Hit Start |
Hit End |
Description |
| 3swm_A | 2e-44 | 8 | 165 | 19 | 174 | NAC domain-containing protein 19 |
| 3swm_B | 2e-44 | 8 | 165 | 19 | 174 | NAC domain-containing protein 19 |
| 3swm_C | 2e-44 | 8 | 165 | 19 | 174 | NAC domain-containing protein 19 |
| 3swm_D | 2e-44 | 8 | 165 | 19 | 174 | NAC domain-containing protein 19 |
| 3swp_A | 2e-44 | 8 | 165 | 19 | 174 | NAC domain-containing protein 19 |
| 3swp_B | 2e-44 | 8 | 165 | 19 | 174 | NAC domain-containing protein 19 |
| 3swp_C | 2e-44 | 8 | 165 | 19 | 174 | NAC domain-containing protein 19 |
| 3swp_D | 2e-44 | 8 | 165 | 19 | 174 | NAC domain-containing protein 19 |
| Search in ModeBase |
| Expression --
Description ? help
Back to Top |
| Source |
Description |
| Uniprot | TISSUE SPECIFICITY: Expressed in root meristem (Ref.1). Expressed in roots, rosette leaves, cauline leaves, shoot apex, stems and flowers (PubMed:17158162). {ECO:0000269|PubMed:17158162, ECO:0000269|Ref.1}. |
| Functional Description ? help
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| Source |
Description |
| TAIR | NAC family member, functions as a transcriptional activator, regulates flavonoid biosynthesis under high light. |
| UniProt | Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP) (By similarity). Transcripition activator associated with the induction of genes related to flavonoid biosynthesis and required for the accumulation of anthocyanins in response to high light stress (PubMed:19887540). Plays a role in the regulation of 20S and 26S proteasomes in response to high light stress (PubMed:21889048). {ECO:0000250|UniProtKB:Q949N0, ECO:0000269|PubMed:19887540, ECO:0000269|PubMed:21889048}. |
| Function -- GeneRIF ? help
Back to Top |
- Molecular mechanisms underlying the cold temperature regulation of flowering time of Arabidopsis are controled by NAC2.
[PMID: 17653269] - ANAC078 protein functions as a transcription factor, and is associated with expression of genes related to flavonoid biosynthesis, leading to the accumulation of anthocyanins, in response to high light stress.
[PMID: 19887540] - ANAC092 strongly responds to long-term salt stress that triggers senescence.
[PMID: 20113437] - The transcript levels of 13 proteasome subunit genes, the protein levels of proteasomes, and the activities of the 26S proteasome in ANAC078-overexpressing Arabidopsis plants (Ox-ANAC078) and knockout ANAC078 (KO-ANAC078) mutants, was investigated.
[PMID: 21889048] - RPX is a negative regulator of leaf organ size. RPX binds to the promoter of genes encoding 26S proteasomal proteins in vivo, resulting in increased gene expression and proteasome activity.
[PMID: 23252408] - PI4K gamma 5 is important for the normal function of ANAC078 and PI4K gamma 5 is required for ANAC078 cleavage and proteolytic activation [ANAC078]
[PMID: 27529511]
|
| Regulation -- Description ? help
Back to Top |
| Source |
Description |
| UniProt | INDUCTION: By exposure to high light (PubMed:19887540). Induced by heat and methyl methanesulfonate (MMS) treatment (PubMed:17158162). {ECO:0000269|PubMed:17158162, ECO:0000269|PubMed:19887540}. |
| Phenotype -- Disruption Phenotype ? help
Back to Top |
| Source |
Description |
| UniProt | DISRUPTION PHENOTYPE: No visible phenotype under normal growth conditions. {ECO:0000269|PubMed:19887540}. |
| Annotation --
Nucleotide ? help
Back to Top |
| Source |
Hit ID |
E-value |
Description |
| GenBank | AY099609 | 0.0 | AY099609.1 Arabidopsis thaliana putative protein (At5g04410) mRNA, complete cds. |
| GenBank | AY128859 | 0.0 | AY128859.1 Arabidopsis thaliana putative protein (At5g04410) mRNA, complete cds. |
| Publications
? help Back to Top |
- Riechmann JL, et al.
Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
Science, 2000. 290(5499): p. 2105-10
[PMID:11118137] - Barrier M,Bustamante CD,Yu J,Purugganan MD
Selection on rapidly evolving proteins in the Arabidopsis genome.
Genetics, 2003. 163(2): p. 723-33
[PMID:12618409] - Yamada K, et al.
Empirical analysis of transcriptional activity in the Arabidopsis genome.
Science, 2003. 302(5646): p. 842-6
[PMID:14593172] - Ooka H, et al.
Comprehensive analysis of NAC family genes in Oryza sativa and Arabidopsis thaliana.
DNA Res., 2003. 10(6): p. 239-47
[PMID:15029955] - Duarte JM, et al.
Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
Mol. Biol. Evol., 2006. 23(2): p. 469-78
[PMID:16280546] - Kim SY, et al.
Exploring membrane-associated NAC transcription factors in Arabidopsis: implications for membrane biology in genome regulation.
Nucleic Acids Res., 2007. 35(1): p. 203-13
[PMID:17158162] - Yoo SY,Kim Y,Kim SY,Lee JS,Ahn JH
Control of flowering time and cold response by a NAC-domain protein in Arabidopsis.
PLoS ONE, 2007. 2(7): p. e642
[PMID:17653269] - Ascencio-Ib
Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.
Plant Physiol., 2008. 148(1): p. 436-54
[PMID:18650403] - Wang Y, et al.
Transcriptome analyses show changes in gene expression to accompany pollen germination and tube growth in Arabidopsis.
Plant Physiol., 2008. 148(3): p. 1201-11
[PMID:18775970] - Morishita T, et al.
Arabidopsis NAC transcription factor, ANAC078, regulates flavonoid biosynthesis under high-light.
Plant Cell Physiol., 2009. 50(12): p. 2210-22
[PMID:19887540] - Balazadeh S, et al.
A gene regulatory network controlled by the NAC transcription factor ANAC092/AtNAC2/ORE1 during salt-promoted senescence.
Plant J., 2010. 62(2): p. 250-64
[PMID:20113437] - Yabuta Y, et al.
Identification of recognition sequence of ANAC078 protein by the cyclic amplification and selection of targets technique.
Plant Signal Behav, 2010. 5(6): p. 695-7
[PMID:20404498] - Shin R,Jez JM,Basra A,Zhang B,Schachtman DP
14-3-3 proteins fine-tune plant nutrient metabolism.
FEBS Lett., 2011. 585(1): p. 143-7
[PMID:21094157] - Yabuta Y, et al.
Involvement of Arabidopsis NAC transcription factor in the regulation of 20S and 26S proteasomes.
Plant Sci., 2011. 181(4): p. 421-7
[PMID:21889048] - Nguyen HM, et al.
An upstream regulator of the 26S proteasome modulates organ size in Arabidopsis thaliana.
Plant J., 2013. 74(1): p. 25-36
[PMID:23252408] - Ding Y, et al.
Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
BMC Plant Biol., 2013. 13: p. 229
[PMID:24377444] - Liang M, et al.
Subcellular Distribution of NTL Transcription Factors in Arabidopsis thaliana.
Traffic, 2015. 16(10): p. 1062-74
[PMID:26201836] - Xiao D, et al.
SENESCENCE-SUPPRESSED PROTEIN PHOSPHATASE Directly Interacts with the Cytoplasmic Domain of SENESCENCE-ASSOCIATED RECEPTOR-LIKE KINASE and Negatively Regulates Leaf Senescence in Arabidopsis.
Plant Physiol., 2015. 169(2): p. 1275-91
[PMID:26304848] - Gladman NP,Marshall RS,Lee KH,Vierstra RD
The Proteasome Stress Regulon Is Controlled by a Pair of NAC Transcription Factors in Arabidopsis.
Plant Cell, 2016. 28(6): p. 1279-96
[PMID:27194708] - Tang Y,Zhao CY,Tan ST,Xue HW
Arabidopsis Type II Phosphatidylinositol 4-Kinase PI4Kγ5 Regulates Auxin Biosynthesis and Leaf Margin Development through Interacting with Membrane-Bound Transcription Factor ANAC078.
PLoS Genet., 2016. 12(8): p. e1006252
[PMID:27529511]
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