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Plant Transcription
Factor Database
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Transcription Factor Information
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Basic
Information? help
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| TF ID |
AT4G37740.1 |
| Common Name | AtGRF2, GRF2, T28I19.20 |
| Organism |
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| Taxonomic ID |
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| Taxonomic Lineage |
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
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| Family |
GRF |
| Protein Properties |
Length: 535aa MW: 58584.9 Da PI: 8.8943 |
| Description |
growth-regulating factor 2 |
| Gene Model |
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| Signature Domain? help Back to Top |
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| No. |
Domain |
Score |
E-value |
Start |
End |
HMM Start |
HMM End |
| 1 | WRC | 78.5 | 6.4e-25 | 227 | 270 | 1 | 44 |
WRC 1 daepgrCrRtDGKkWRCsrrvlegkklCErHlhrgrsrsrkske 44
d+epgrCrRtDGKkWRCsr++++++k+CErH++rgr+rsrk++e
AT4G37740.1 227 DPEPGRCRRTDGKKWRCSRDAVPDQKYCERHINRGRHRSRKPVE 270
79***************************************998 PP
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| 2 | QLQ | 53.4 | 8e-19 | 163 | 199 | 1 | 37 |
QLQ 1 saFTaaQlqlLksQilAyKyLaanqPvPpeLlqaiqk 37
++FT +Q+++L++Q+l+yKy+ an+PvP+ Ll i+k
AT4G37740.1 163 GPFTLTQWAELEQQALIYKYITANVPVPSSLLISIKK 199
59******************************99986 PP
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| Sequence ? help Back to Top |
| Protein Sequence Length: 535 aa
Download sequence Send
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MDIGVHVLGS VTSNENESLG LKELIGTKQD RSGFIGEDCL QRSLKLARTT TRAEEEENLS 60
SSVAAAYCKT MSFHQGIPLM RSASPLSSDS RRQEQMLSFS DKPDALDFSK YVGLDNSSNN 120
KNSLSPFLHQ IPPPSYFRSS GGYGSGGMMM NMSMQGNFTG VKGPFTLTQW AELEQQALIY 180
KYITANVPVP SSLLISIKKS FYPYGSLPPS SFGWGTFHLG FAGGNMDPEP GRCRRTDGKK 240
WRCSRDAVPD QKYCERHINR GRHRSRKPVE VQSGQNQTAA AASKAVTTPQ QPVVAGNTNR 300
SNARASSNRS LAIGSQYINP STESLPNNRG VSIYPSTVNL QPKESPVIHQ KHRNNNNPFE 360
FGHISSDSLL NPNTAKTYGS SFLDFSSNQE KHSGNHNHNS WPEELTSDWT QLSMSIPIAS 420
SSPSSTHNNN NAQEKTTLSP LRLSRELDLS IQTDETTIEP TVKKVNTWIP ISWGNSLGGP 480
LGEVLNSTTN SPTFGSSPTG VLQKSTFCSL SNNSSVSSPI AENNRHNGDY FHYTT
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| Expression --
Description ? help
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| Source |
Description |
| Uniprot | DEVELOPMENTAL STAGE: Expressed during the early stages of leaf development and expression decreases with the maturation of the leaf. {ECO:0000269|PubMed:20023165}. |
| Uniprot | TISSUE SPECIFICITY: Strongly expressed in actively growing and developing tissues, such as roots, upper stems, and shoot tips containing the shoot apical meristem (SAM) and flower buds. Detected in young leaf primordium. Also expressed in mature flowers, but weakly expressed in mature stems and leaves. {ECO:0000269|PubMed:12974814, ECO:0000269|PubMed:21036927}. |
| Functional Description ? help
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| Source |
Description |
| TAIR | Growth regulating factor encoding transcription activator. One of the nine members of a GRF gene family, containing nuclear targeting domain. Mutants result in smaller leaves indicating the role of the gene in leaf development. Expressed in root, shoot and flower |
| UniProt | Transcription activator that plays a role in the regulation of cell expansion in leaf and cotyledons tissues. Component of a network formed by miR396, the GRFs and their interacting factors (GIFs) acting in the regulation of meristem function, at least partially through the control of cell proliferation. {ECO:0000269|PubMed:12974814, ECO:0000269|PubMed:15326298, ECO:0000269|PubMed:20023165, ECO:0000269|PubMed:21036927}. |
| Function -- GeneRIF ? help
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- MiR396 accumulates preferentially in the distal part of young developing leaves, restricting the expression of GRF2 to the proximal part of the organ.
[PMID: 20023165] - Our data indicate that such bulge modulates the strength of the miR396-mediated repression and that this modulation is essential to shape the precise spatio-temporal pattern of GRF2 expression
[PMID: 22242012]
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| Regulation -- Description ? help
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| Source |
Description |
| UniProt | INDUCTION: microRNA 396 (miR396a or miR396b) negatively regulates growth-regulating factors (GRF1-4 and GRF7-9). {ECO:0000269|PubMed:15200956, ECO:0000269|PubMed:19453503, ECO:0000269|PubMed:20023165}. |
| Annotation --
Nucleotide ? help
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| Source |
Hit ID |
E-value |
Description |
| GenBank | AK176432 | 0.0 | AK176432.1 Arabidopsis thaliana mRNA for transcription activator (GRL2), complete cds, clone: RAFL24-18-E23. |
| GenBank | AY102635 | 0.0 | AY102635.1 Arabidopsis thaliana transcription activator (GRF2) mRNA, complete cds. |
| Publications
? help Back to Top |
- Kim JH,Choi D,Kende H
The AtGRF family of putative transcription factors is involved in leaf and cotyledon growth in Arabidopsis.
Plant J., 2003. 36(1): p. 94-104
[PMID:12974814] - Jones-Rhoades MW,Bartel DP
Computational identification of plant microRNAs and their targets, including a stress-induced miRNA.
Mol. Cell, 2004. 14(6): p. 787-99
[PMID:15200956] - Kim JH,Kende H
A transcriptional coactivator, AtGIF1, is involved in regulating leaf growth and morphology in Arabidopsis.
Proc. Natl. Acad. Sci. U.S.A., 2004. 101(36): p. 13374-9
[PMID:15326298] - Wang XJ,Reyes JL,Chua NH,Gaasterland T
Prediction and identification of Arabidopsis thaliana microRNAs and their mRNA targets.
Genome Biol., 2004. 5(9): p. R65
[PMID:15345049] - Liu D,Song Y,Chen Z,Yu D
Ectopic expression of miR396 suppresses GRF target gene expression and alters leaf growth in Arabidopsis.
Physiol Plant, 2009. 136(2): p. 223-36
[PMID:19453503] - Rodriguez RE, et al.
Control of cell proliferation in Arabidopsis thaliana by microRNA miR396.
Development, 2010. 137(1): p. 103-12
[PMID:20023165] - Wang L, et al.
miR396-targeted AtGRF transcription factors are required for coordination of cell division and differentiation during leaf development in Arabidopsis.
J. Exp. Bot., 2011. 62(2): p. 761-73
[PMID:21036927] - Debernardi JM,Rodriguez RE,Mecchia MA,Palatnik JF
Functional specialization of the plant miR396 regulatory network through distinct microRNA-target interactions.
PLoS Genet., 2012. 8(1): p. e1002419
[PMID:22242012] - Casadevall R,Rodriguez RE,Debernardi JM,Palatnik JF,Casati P
Repression of growth regulating factors by the microRNA396 inhibits cell proliferation by UV-B radiation in Arabidopsis leaves.
Plant Cell, 2013. 25(9): p. 3570-83
[PMID:24076976] - Liang G,He H,Li Y,Wang F,Yu D
Molecular mechanism of microRNA396 mediating pistil development in Arabidopsis.
Plant Physiol., 2014. 164(1): p. 249-58
[PMID:24285851] - Liu J,Rice JH,Chen N,Baum TJ,Hewezi T
Synchronization of developmental processes and defense signaling by growth regulating transcription factors.
PLoS ONE, 2014. 9(5): p. e98477
[PMID:24875638] - Rodriguez RE, et al.
MicroRNA miR396 Regulates the Switch between Stem Cells and Transit-Amplifying Cells in Arabidopsis Roots.
Plant Cell, 2015. 27(12): p. 3354-66
[PMID:26645252] - Cao Y,Han Y,Jin Q,Lin Y,Cai Y
Comparative Genomic Analysis of the GRF Genes in Chinese Pear (Pyrus bretschneideri Rehd), Poplar (Populous), Grape (Vitis vinifera), Arabidopsis and Rice (Oryza sativa).
Front Plant Sci, 2016. 7: p. 1750
[PMID:27933074]
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