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Plant Transcription
Factor Database
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Transcription Factor Information
Basic
Information? help
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TF ID |
AT4G25560.1 |
Common Name | AtMYB18, LAF1, M7J2.70, MYB18 |
Organism |
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Taxonomic ID |
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Taxonomic Lineage |
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
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Family |
MYB |
Protein Properties |
Length: 283aa MW: 32433 Da PI: 7.9027 |
Description |
myb domain protein 18 |
Gene Model |
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Signature Domain? help Back to Top |
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No. |
Domain |
Score |
E-value |
Start |
End |
HMM Start |
HMM End |
1 | Myb_DNA-binding | 42.2 | 1.9e-13 | 12 | 59 | 1 | 48 |
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHHHT CS
Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqkyl 48
+g W++eEde+l + +G +W+t++ + g+ R +k+c++rw +yl
AT4G25560.1 12 KGLWSPEEDEKLRSFILSYGHSCWTTVPIKAGLQRNGKSCRLRWINYL 59
678*******************************************97 PP
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2 | Myb_DNA-binding | 43.8 | 5.8e-14 | 69 | 110 | 5 | 48 |
-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHHHT CS
Myb_DNA-binding 5 TteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqkyl 48
++eE+e ++ + lG++ W+ Ia+ ++ gRt++++k++w+++l
AT4G25560.1 69 SAEEEETILTFHSSLGNK-WSQIAKFLP-GRTDNEIKNYWHSHL 110
89****************.*********.************986 PP
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Gene Ontology ? help Back to Top |
GO Term |
GO Category |
GO Description |
GO:0006357 | Biological Process | regulation of transcription from RNA polymerase II promoter |
GO:0009585 | Biological Process | red, far-red light phototransduction |
GO:0009751 | Biological Process | response to salicylic acid |
GO:0010018 | Biological Process | far-red light signaling pathway |
GO:0030154 | Biological Process | cell differentiation |
GO:0045893 | Biological Process | positive regulation of transcription, DNA-templated |
GO:0005634 | Cellular Component | nucleus |
GO:0016607 | Cellular Component | nuclear speck |
GO:0000981 | Molecular Function | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
GO:0001135 | Molecular Function | transcription factor activity, RNA polymerase II transcription factor recruiting |
GO:0005515 | Molecular Function | protein binding |
GO:0043565 | Molecular Function | sequence-specific DNA binding |
GO:0044212 | Molecular Function | transcription regulatory region DNA binding |
Sequence ? help Back to Top |
Protein Sequence Length: 283 aa
Download sequence Send
to blast |
MAKTKYGERH RKGLWSPEED EKLRSFILSY GHSCWTTVPI KAGLQRNGKS CRLRWINYLR 60 PGLKRDMISA EEEETILTFH SSLGNKWSQI AKFLPGRTDN EIKNYWHSHL KKKWLKSQSL 120 QDAKSISPPS SSSSSLVACG KRNPETLISN HVFSFQRLLE NKSSSPSQES NGNNSHQCSS 180 APEIPRLFFS EWLSSSYPHT DYSSEFTDSK HSQAPNVEET LSAYEEMGDV DQFHYNEMMI 240 NNSNWTLNDI VFGSKCKKQE HHIYREASDC NSSAEFFSPS TTT
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Expression --
Description ? help
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Source |
Description |
Uniprot | TISSUE SPECIFICITY: Expressed at very low level. Expressed in cauline leaves. {ECO:0000269|PubMed:11581165}. |
Functional Description ? help
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Source |
Description |
TAIR | Member of the R2R3 factor gene family. |
UniProt | Transcription factor that promotes photomorphogenesis in the light by participating in the transmission of phytochrome A (phyA) signals to downstream responses (PubMed:11581165, PubMed:19482971). Probably acts by activating expression of light-induced genes. In darkness, its degradation prevents the activation of light-induced genes (PubMed:11581165). {ECO:0000269|PubMed:11581165, ECO:0000269|PubMed:19482971}. |
Function -- GeneRIF ? help
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- in addition to their independent functions in phyA signaling, LAF1 and HFR1 also cooperate post-translationally to stabilize each other through inhibition of ubiquitination by COP1, thereby enhancing phyA photoresponses
[PMID: 17699755] - HY5 transmits phyA signals through an FHY1/FHL-independent pathway but it may also modulate FHY1/FHL signal through its interaction with HFR1 and LAF1.[LAF1]
[PMID: 23503597]
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Regulation -- Description ? help
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Source |
Description |
UniProt | INDUCTION: By hormones or elicitors treatment. By exposure to abiotic stress. {ECO:0000269|PubMed:9839469}. |
Phenotype -- Disruption Phenotype ? help
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Source |
Description |
UniProt | DISRUPTION PHENOTYPE: Partially blind to far-red (FR). Impaired inhibition of hypocotyl elongation and cotyledons expansion under continuous FR light conditions. {ECO:0000269|PubMed:19482971}. |
Annotation --
Nucleotide ? help
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Source |
Hit ID |
E-value |
Description |
GenBank | AY519609 | 0.0 | AY519609.1 Arabidopsis thaliana MYB transcription factor (At4g25560) mRNA, complete cds. |
Orthologous Group
? help Back to Top |
Lineage | Orthologous Group ID | Taxa Number | Gene Number |
Malvids | OGEM4 | 28 | 2646 |
Representative plant | OGRP5 | 17 | 1784 |
Publications
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- Riechmann JL, et al.
Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] - Ballesteros ML, et al.
LAF1, a MYB transcription activator for phytochrome A signaling. Genes Dev., 2001. 15(19): p. 2613-25 [PMID:11581165] - Stracke R,Werber M,Weisshaar B
The R2R3-MYB gene family in Arabidopsis thaliana. Curr. Opin. Plant Biol., 2001. 4(5): p. 447-56 [PMID:11597504] - Seo HS, et al.
LAF1 ubiquitination by COP1 controls photomorphogenesis and is stimulated by SPA1. Nature, 2003. 423(6943): p. 995-9 [PMID:12827204] - Gong W, et al.
Genome-wide ORFeome cloning and analysis of Arabidopsis transcription factor genes. Plant Physiol., 2004. 135(2): p. 773-82 [PMID:15208423] - Jang IC,Yang JY,Seo HS,Chua NH
HFR1 is targeted by COP1 E3 ligase for post-translational proteolysis during phytochrome A signaling. Genes Dev., 2005. 19(5): p. 593-602 [PMID:15741320] - Yang J, et al.
Repression of light signaling by Arabidopsis SPA1 involves post-translational regulation of HFR1 protein accumulation. Plant J., 2005. 43(1): p. 131-41 [PMID:15960622] - Duarte JM, et al.
Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis. Mol. Biol. Evol., 2006. 23(2): p. 469-78 [PMID:16280546] - Yanhui C, et al.
The MYB transcription factor superfamily of Arabidopsis: expression analysis and phylogenetic comparison with the rice MYB family. Plant Mol. Biol., 2006. 60(1): p. 107-24 [PMID:16463103] - Jang IC,Yang SW,Yang JY,Chua NH
Independent and interdependent functions of LAF1 and HFR1 in phytochrome A signaling. Genes Dev., 2007. 21(16): p. 2100-11 [PMID:17699755] - Yang SW,Jang IC,Henriques R,Chua NH
FAR-RED ELONGATED HYPOCOTYL1 and FHY1-LIKE associate with the Arabidopsis transcription factors LAF1 and HFR1 to transmit phytochrome A signals for inhibition of hypocotyl elongation. Plant Cell, 2009. 21(5): p. 1341-59 [PMID:19482971] - Gong W, et al.
The development of protein microarrays and their applications in DNA-protein and protein-protein interaction analyses of Arabidopsis transcription factors. Mol Plant, 2008. 1(1): p. 27-41 [PMID:19802365] - Jang IC,Henriques R,Chua NH
Three transcription factors, HFR1, LAF1 and HY5, regulate largely independent signaling pathways downstream of phytochrome A. Plant Cell Physiol., 2013. 54(6): p. 907-16 [PMID:23503597] - Kranz HD, et al.
Towards functional characterisation of the members of the R2R3-MYB gene family from Arabidopsis thaliana. Plant J., 1998. 16(2): p. 263-76 [PMID:9839469]
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