PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

bHLH

Protein Properties

Length: 310aa MW: 33105.4 Da PI: 6.313

Description

bHLH family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT4G02590.2	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HLH	27.1	7.7e-09	157	201	5	54
HHHHHHHHHHHHHHHHHHHHCTSCC.C...TTS-STCHHHHHHHHHHHHHH CS HLH 5 hnerErrRRdriNsafeeLrellPk.askapskKlsKaeiLekAveYIksL 54 h+++Er RR+ri +++ L+el+P+ + K + a++ + v+Y+k L AT4G02590.2 157 HSIAERLRRERIAERIRALQELVPTvN------KTDRAAMIDEIVDYVKFL 201 99*********************55......9************998 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF47459	1.44E-14	150	211	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profile	PS50888	15.802	152	201	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Gene3D	G3DSA:4.10.280.10	4.6E-14	154	211	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Pfam	PF00010	2.9E-6	157	201	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SMART	SM00353	7.0E-10	158	207	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0007275	Biological Process	multicellular organism development
GO:0009567	Biological Process	double fertilization forming a zygote and endosperm
GO:0031347	Biological Process	regulation of defense response
GO:0045944	Biological Process	positive regulation of transcription from RNA polymerase II promoter
GO:0005634	Cellular Component	nucleus
GO:0001046	Molecular Function	core promoter sequence-specific DNA binding
GO:0001228	Molecular Function	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0046983	Molecular Function	protein dimerization activity

Plant Ontology ? help Back to Top
PO Term	PO Category	PO Description
PO:0000013	anatomy	cauline leaf
PO:0000037	anatomy	shoot apex
PO:0000230	anatomy	inflorescence meristem
PO:0000293	anatomy	guard cell
PO:0008019	anatomy	leaf lamina base
PO:0009005	anatomy	root
PO:0009006	anatomy	shoot system
PO:0009009	anatomy	plant embryo
PO:0009010	anatomy	seed
PO:0009025	anatomy	vascular leaf
PO:0009029	anatomy	stamen
PO:0009030	anatomy	carpel
PO:0009031	anatomy	sepal
PO:0009032	anatomy	petal
PO:0009046	anatomy	flower
PO:0009047	anatomy	stem
PO:0009052	anatomy	flower pedicel
PO:0020030	anatomy	cotyledon
PO:0020038	anatomy	petiole
PO:0020100	anatomy	hypocotyl
PO:0020137	anatomy	leaf apex
PO:0025022	anatomy	collective leaf structure
PO:0025281	anatomy	pollen
PO:0001054	developmental stage	vascular leaf senescent stage
PO:0001078	developmental stage	plant embryo cotyledonary stage
PO:0001081	developmental stage	mature plant embryo stage
PO:0001185	developmental stage	plant embryo globular stage
PO:0004507	developmental stage	plant embryo bilateral stage
PO:0007064	developmental stage	LP.12 twelve leaves visible stage
PO:0007095	developmental stage	LP.08 eight leaves visible stage
PO:0007098	developmental stage	LP.02 two leaves visible stage
PO:0007103	developmental stage	LP.10 ten leaves visible stage
PO:0007115	developmental stage	LP.04 four leaves visible stage
PO:0007123	developmental stage	LP.06 six leaves visible stage
PO:0007611	developmental stage	petal differentiation and expansion stage
PO:0007616	developmental stage	flowering stage

Sequence ? help Back to Top
Protein Sequence Length: 310 aa Download sequence Send to blast
MASNNPHDNL SDQTPSDDFF EQILGLPNFS ASSAAGLSGV DGGLGGGAPP MMLQLGSGEE 60 GSHMGGLGGS GPTGFHNQMF PLGLSLDQGK GPGFLRPEGG HGSGKRFSDD VVDNRCSSMK 120 PVFHGQPMQQ PPPSAPHQPT SIRPRVRARR GQATDPHSIA ERLRRERIAE RIRALQELVP 180 TVNKTDRAAM IDEIVDYVKF LRLQVKVLSM SRLGGAGAVA PLVTDMPLSS SVEDETGEGG 240 RTPQPAWEKW SNDGTERQVA KLMEENVGAA MQLLQSKALC MMPISLAMAI YHSQPPDTSS 300 VVKPENNPPQ

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	161	166	RLRRER

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
At.20028	0.0	bud\| flower\| leaf\| root\| seed\| vegetative tissue

Expression -- Microarray ? help Back to Top
Source	ID	E-value
GEO	30679204	0.0
Genevisible	255497_at	0.0
Expression Atlas	AT4G02590	-
AtGenExpress	AT4G02590	-
ATTED-II	AT4G02590	-

Expression -- Description ? help Back to Top
Source	Description
Uniprot	TISSUE SPECIFICITY: Expressed constitutively in roots, leaves, stems, and flowers. {ECO:0000269\|PubMed:12679534}.

Functional Description ? help Back to Top
Source	Description
UniProt	Required for ovule fertilization. {ECO:0000269\|PubMed:15634699}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT4G02590.2

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Interaction ? help Back to Top
Source	Intact With
BioGRID	AT1G03040, AT1G31050, AT1G62990, AT1G77950
IntAct	Search O22768

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT4G02590

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AF367328	0.0	AF367328.1 Arabidopsis thaliana AT4g02590/T10P11_13 mRNA, complete cds.
GenBank	AK316748	0.0	AK316748.1 Arabidopsis thaliana AT4G02590 mRNA, complete cds, clone: RAFL07-83-K16.
GenBank	AY143951	0.0	AY143951.1 Arabidopsis thaliana At4g02590/T10P11_13 mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_001031577.1	0.0	basic helix-loop-helix (bHLH) DNA-binding superfamily protein
Refseq	NP_567245.1	0.0	basic helix-loop-helix (bHLH) DNA-binding superfamily protein
Swissprot	O22768	0.0	UNE12_ARATH; Transcription factor UNE12
TrEMBL	A0A384KS03	0.0	A0A384KS03_ARATH; UNE12
TrEMBL	B9DFF4	0.0	B9DFF4_ARATH; AT4G02590 protein
STRING	AT4G02590.1	0.0	(Arabidopsis thaliana)

Link Out ? help Back to Top
Phytozome	AT4G02590.2
Entrez Gene	828126
iHOP	AT4G02590
wikigenes	AT4G02590

Publications ? help Back to Top
Riechmann JL, et al. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] Heim MA, et al. The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity. Mol. Biol. Evol., 2003. 20(5): p. 735-47 [PMID:12679534] Toledo-Ortiz G,Huq E,Quail PH The Arabidopsis basic/helix-loop-helix transcription factor family. Plant Cell, 2003. 15(8): p. 1749-70 [PMID:12897250] Yamada K, et al. Empirical analysis of transcriptional activity in the Arabidopsis genome. Science, 2003. 302(5646): p. 842-6 [PMID:14593172] Bailey PC, et al. Update on the basic helix-loop-helix transcription factor gene family in Arabidopsis thaliana. Plant Cell, 2003. 15(11): p. 2497-502 [PMID:14600211] Pagnussat GC, et al. Genetic and molecular identification of genes required for female gametophyte development and function in Arabidopsis. Development, 2005. 132(3): p. 603-14 [PMID:15634699] Ascencio-Ib Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection. Plant Physiol., 2008. 148(1): p. 436-54 [PMID:18650403] Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature. Differentiation, 2010. 80(1): p. 1-8 [PMID:20219281] Brady SM, et al. A stele-enriched gene regulatory network in the Arabidopsis root. Mol. Syst. Biol., 2011. 7: p. 459 [PMID:21245844] Mukhtar MS, et al. Independently evolved virulence effectors converge onto hubs in a plant immune system network. Science, 2011. 333(6042): p. 596-601 [PMID:21798943] Arabidopsis Interactome Mapping Consortium Evidence for network evolution in an Arabidopsis interactome map. Science, 2011. 333(6042): p. 601-7 [PMID:21798944] Efroni I, et al. Regulation of leaf maturation by chromatin-mediated modulation of cytokinin responses. Dev. Cell, 2013. 24(4): p. 438-45 [PMID:23449474] Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] We Convergent targeting of a common host protein-network by pathogen effectors from three kingdoms of life. Cell Host Microbe, 2014. 16(3): p. 364-75 [PMID:25211078]