PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

MYB

Protein Properties

Length: 437aa MW: 50032.2 Da PI: 9.5217

Description

myb domain protein 3r2

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT4G00540.1	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	Myb_DNA-binding	53.9	4.2e-17	44	95	1	48
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHT....TTS-HHHHHHHHHHHT CS Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmg....kgRtlkqcksrwqkyl 48 +g WT+eEd++l ++vk++ g++Wk+Ia++++ ++R + qc++rw+k+l AT4G00540.1 44 KGGWTAEEDQILTNVVKKYQGRNWKRIAECLPgseeNRRNDVQCQHRWLKVL 95 688**********************************************986 PP
2	Myb_DNA-binding	47.7	3.6e-15	101	150	1	48
TSSS-HHHHHHHHHHHHHTTTT...-HHHHHHHHTTTS-HHHHHHHHHHHT CS Myb_DNA-binding 1 rgrWTteEdellvdavkqlGgg...tWktIartmgkgRtlkqcksrwqkyl 48 +g+W +eEdell ++vk + + W++I+++++ gR +kqc++rw+++l AT4G00540.1 101 KGAWKKEEDELLSELVKDYMENdrpPWSKISKELP-GRIGKQCRERWHNHL 150 79****************99*********.***********97 PP
3	Myb_DNA-binding	50.1	6.6e-16	156	198	1	45
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHH CS Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwq 45 + +WT eE+++lv+a + G++ W+ Ia+ ++ gRt++++k++w+ AT4G00540.1 156 KSPWTREEELILVQAQRGNGNK-WAEIAKLLP-GRTENNIKNHWN 198 679*****************.*****.*********8 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS51294	11.888	39	95	IPR017930	Myb domain
SMART	SM00717	1.4E-14	43	97	IPR001005	SANT/Myb domain
SuperFamily	SSF46689	2.14E-16	45	118	IPR009057	Homeodomain-like
Gene3D	G3DSA:1.10.10.60	1.2E-20	46	107	IPR009057	Homeodomain-like
CDD	cd00167	2.38E-11	47	95	No hit	No description
Pfam	PF13921	1.6E-17	47	112	No hit	No description
PROSITE profile	PS51294	27.387	96	154	IPR017930	Myb domain
SMART	SM00717	4.9E-16	100	152	IPR001005	SANT/Myb domain
CDD	cd00167	3.53E-12	103	150	No hit	No description
Gene3D	G3DSA:1.10.10.60	8.9E-23	108	157	IPR009057	Homeodomain-like
SuperFamily	SSF46689	4.05E-27	130	207	IPR009057	Homeodomain-like
PROSITE profile	PS51294	19.085	155	205	IPR017930	Myb domain
SMART	SM00717	2.1E-13	155	203	IPR001005	SANT/Myb domain
Pfam	PF00249	7.3E-14	156	198	IPR001005	SANT/Myb domain
Gene3D	G3DSA:1.10.10.60	2.7E-19	158	205	IPR009057	Homeodomain-like
CDD	cd00167	1.35E-9	158	198	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006357	Biological Process	regulation of transcription from RNA polymerase II promoter
GO:0030154	Biological Process	cell differentiation
GO:0005634	Cellular Component	nucleus
GO:0000981	Molecular Function	RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001135	Molecular Function	transcription factor activity, RNA polymerase II transcription factor recruiting
GO:0043565	Molecular Function	sequence-specific DNA binding
GO:0044212	Molecular Function	transcription regulatory region DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 437 aa Download sequence Send to blast
MTESIDLNRS ESESDNNTDD VTPIFAIDDS SKGRVSGPTR RSTKGGWTAE EDQILTNVVK 60 KYQGRNWKRI AECLPGSEEN RRNDVQCQHR WLKVLDPSLQ KGAWKKEEDE LLSELVKDYM 120 ENDRPPWSKI SKELPGRIGK QCRERWHNHL NPTIIKSPWT REEELILVQA QRGNGNKWAE 180 IAKLLPGRTE NNIKNHWNCS VKKRLEQFPS NLFSGVVYGS KPSSGFEYNF FNQRNTMVES 240 CITSQIKEAA KSPQRDFLDL TLGLNWRSIS SSTSSLRGEE SVSSSVDSVC ARLNACLETP 300 QNSNNDTVCV KEVREMKERL RMAARTFDTP SIISKTSSPA SGLKRLRQKY DTPFPTDARS 360 HMSSEEDHSV SASPSSKYRF VKRNTCSGSK PLERRLDFDF LLWDEHGRRN GIVNFSVRIL 420 PQKSDLKSGL VRPFWLR

Sequence ? help Back to Top

Protein Sequence Length: 437 aa Download sequence Send to blast

MTESIDLNRS ESESDNNTDD VTPIFAIDDS SKGRVSGPTR RSTKGGWTAE EDQILTNVVK  60
KYQGRNWKRI AECLPGSEEN RRNDVQCQHR WLKVLDPSLQ KGAWKKEEDE LLSELVKDYM  120
ENDRPPWSKI SKELPGRIGK QCRERWHNHL NPTIIKSPWT REEELILVQA QRGNGNKWAE  180
IAKLLPGRTE NNIKNHWNCS VKKRLEQFPS NLFSGVVYGS KPSSGFEYNF FNQRNTMVES  240
CITSQIKEAA KSPQRDFLDL TLGLNWRSIS SSTSSLRGEE SVSSSVDSVC ARLNACLETP  300
QNSNNDTVCV KEVREMKERL RMAARTFDTP SIISKTSSPA SGLKRLRQKY DTPFPTDARS  360
HMSSEEDHSV SASPSSKYRF VKRNTCSGSK PLERRLDFDF LLWDEHGRRN GIVNFSVRIL  420
PQKSDLKSGL VRPFWLR

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1h88_C	9e-52	47	205	9	159	MYB PROTO-ONCOGENE PROTEIN
1h89_C	9e-52	47	205	9	159	MYB PROTO-ONCOGENE PROTEIN
Search in ModeBase

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
At.3762	0.0	seed

Expression -- Microarray ? help Back to Top
Source	ID
Expression Atlas	AT4G00540
AtGenExpress	AT4G00540

Functional Description ? help Back to Top
Source	Description
TAIR	Encodes a putative c-myb-like transcription factor. Member of a class of domain proteins containing structural features of the vertebrate c-Myb proto-oncoprotein, including the presence of three Myb motifs (R1,R2,R3).
UniProt	Transcription factor that binds 5'-AACGG-3' motifs in gene promoters (By similarity). Required for proper circadian rhythm (PubMed:18426557). {ECO:0000250\|UniProtKB:Q94FL9, ECO:0000269\|PubMed:18426557}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT4G00540.1

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT4G00540

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AF151647	0.0	AF151647.1 Arabidopsis thaliana PC-MYB2 (PC-MYB2) mRNA, complete cds.
GenBank	AF218054	0.0	AF218054.2 Arabidopsis thaliana putative c-myb-like transcription factor (MYB3R2) mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_567179.1	0.0	myb domain protein 3r2
Swissprot	Q9SPN3	0.0	MB3R2_ARATH; Transcription factor MYB3R-2
TrEMBL	F4JHD4	0.0	F4JHD4_ARATH; Myb domain protein 3r2
STRING	AT4G00540.1	0.0	(Arabidopsis thaliana)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM1667	28	87
Representative plant	OGRP5	17	1784

Link Out ? help Back to Top
Phytozome	AT4G00540.1
Entrez Gene	827977
iHOP	AT4G00540
wikigenes	AT4G00540

Publications ? help Back to Top
Braun EL,Grotewold E Newly discovered plant c-myb-like genes rewrite the evolution of the plant myb gene family. Plant Physiol., 1999. 121(1): p. 21-4 [PMID:10482656] Riechmann JL, et al. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] Stracke R,Werber M,Weisshaar B The R2R3-MYB gene family in Arabidopsis thaliana. Curr. Opin. Plant Biol., 2001. 4(5): p. 447-56 [PMID:11597504] Haga N, et al. R1R2R3-Myb proteins positively regulate cytokinesis through activation of KNOLLE transcription in Arabidopsis thaliana. Development, 2007. 134(6): p. 1101-10 [PMID:17287251] Hanano S, et al. A systematic survey in Arabidopsis thaliana of transcription factors that modulate circadian parameters. BMC Genomics, 2008. 9: p. 182 [PMID:18426557] Hanada K, et al. Functional compensation of primary and secondary metabolites by duplicate genes in Arabidopsis thaliana. Mol. Biol. Evol., 2011. 28(1): p. 377-82 [PMID:20736450] Causier B,Ashworth M,Guo W,Davies B The TOPLESS interactome: a framework for gene repression in Arabidopsis. Plant Physiol., 2012. 158(1): p. 423-38 [PMID:22065421] Chen P, et al. Arabidopsis R1R2R3-Myb proteins are essential for inhibiting cell division in response to DNA damage. Nat Commun, 2017. 8(1): p. 635 [PMID:28935922]