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Plant Transcription
Factor Database
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Transcription Factor Information
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Basic
Information? help
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| TF ID |
AT4G00480.1 |
| Common Name | ATMYC1, BHLH12, EN58, F6N23.22, myc1 |
| Organism |
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| Taxonomic ID |
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| Taxonomic Lineage |
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
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| Family |
bHLH |
| Protein Properties |
Length: 526aa MW: 59987.8 Da PI: 6.703 |
| Description |
bHLH family protein |
| Gene Model |
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| Signature Domain? help Back to Top |
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| No. |
Domain |
Score |
E-value |
Start |
End |
HMM Start |
HMM End |
| 1 | HLH | 18.5 | 3.6e-06 | 346 | 383 | 13 | 55 |
HHHHHHHHHHHHCTSCC.C...TTS-STCHHHHHHHHHHHHHHH CS
HLH 13 RdriNsafeeLrellPk.askapskKlsKaeiLekAveYIksLq 55
R++ N++f+ Lr+++P+ + ++K +iL +++Y+++L+
AT4G00480.1 346 RRKENEKFSVLRTMVPTvN------EVDKESILNNTIKYLQELE 383
6777*************65......8***************995 PP
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| Gene Ontology ? help Back to Top |
| GO Term |
GO Category |
GO Description |
| GO:0006355 | Biological Process | regulation of transcription, DNA-templated |
| GO:0048629 | Biological Process | trichome patterning |
| GO:0005634 | Cellular Component | nucleus |
| GO:0003677 | Molecular Function | DNA binding |
| GO:0003700 | Molecular Function | transcription factor activity, sequence-specific DNA binding |
| GO:0005515 | Molecular Function | protein binding |
| GO:0046983 | Molecular Function | protein dimerization activity |
| Sequence ? help Back to Top |
| Protein Sequence Length: 526 aa
Download sequence Send
to blast |
MSLTMADGVE AAAGRSKRQN SLLRKQLALA VRSVQWSYAI FWSSSLTQPG VLEWGEGCYN 60
GDMKKRKKSY ESHYKYGLQK SKELRKLYLS MLEGDSGTTV STTHDNLNDD DDNCHSTSMM 120
LSPDDLSDEE WYYLVSMSYV FSPSQCLPGR ASATGETIWL CNAQYAENKL FSRSLLARSA 180
SIQTVVCFPY LGGVIELGVT ELISEDHNLL RNIKSCLMEI SAHQDNDDEK KMEIKISEEK 240
HQLPLGISDE DLHYKRTIST VLNYSADRSG KNDKNIRHRQ PNIVTSEPGS SFLRWKQCEQ 300
QVSGFVQKKK SQNVLRKILH DVPLMHTKRM FPSQNSGLNQ DDPSDRRKEN EKFSVLRTMV 360
PTVNEVDKES ILNNTIKYLQ ELEARVEELE SCMGSVNFVE RQRKTTENLN DSVLIEETSG 420
NYDDSTKIDD NSGETEQVTV FRDKTHLRVK LKETEVVIEV RCSYRDYIVA DIMETLSNLH 480
MDAFSVRSHT LNKFLTLNLK AKFRGAAVAS VGMIKRELRR VIGDLF
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| 3D Structure ? help Back to Top |
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| PDB ID |
Evalue |
Query Start |
Query End |
Hit Start |
Hit End |
Description |
| 4rqw_A | 2e-12 | 23 | 217 | 9 | 192 | Transcription factor MYC3 |
| 4rqw_B | 2e-12 | 23 | 217 | 9 | 192 | Transcription factor MYC3 |
| 4rs9_A | 2e-12 | 23 | 217 | 9 | 192 | Transcription factor MYC3 |
| 4yz6_A | 2e-12 | 23 | 217 | 9 | 192 | Transcription factor MYC3 |
| Search in ModeBase |
| Expression --
Description ? help
Back to Top |
| Source |
Description |
| Uniprot | TISSUE SPECIFICITY: Mostly expressed in developing seeds. Also detected in stems and leaves. {ECO:0000269|PubMed:12679534, ECO:0000269|PubMed:8980509}. |
| Functional Description ? help
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| Source |
Description |
| TAIR | MYC-related protein with a basic helix-loop-helix motif at the C-terminus and a region similar to the maize B/R family at the N-terminus |
| UniProt | Trancsription activator, when associated with MYB75/PAP1 or MYB90/PAP2. {ECO:0000269|PubMed:15361138}. |
| Function -- GeneRIF ? help
Back to Top |
- Natural allelic variation defines a role for ATMYC1: trichome cell fate determination
[PMID: 21695236] - AtMYC1 is an important regulator of trichome and root hair initiation
[PMID: 22334670] - AtMYC1 protein is predominantly localised in the cytoplasm and can relocate GL1 from the nucleus into the cytoplasm.
[PMID: 23900543]
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| Regulation -- Description ? help
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| Source |
Description |
| UniProt | INDUCTION: By cold, UV, flagellin, jasmonic acid (JA), and salicylic acid (SA) treatments. {ECO:0000269|PubMed:12679534}. |
| Interaction -- BIND ? help
Back to Top |
| Source |
Intact With |
Description |
| BIND | AT1G56650 | MYC1 (AtBHLH012) interacts with PAP1. |
| BIND | AT1G66370 | MYC1 (AtBHLH012) interacts with MYB113. |
| BIND | AT1G66380 | MYC1 (AtBHLH012) interacts with MYB114. |
| BIND | AT1G66390 | MYC1 (AtBHLH012) interacts with PAP2. |
| BIND | AT4G38620 | MYC1 (AtBHLH012) interacts with MYB4. |
| BIND | AT5G14750 | MYC1 (AtBHLH012) interacts with WER. |
| BIND | AT5G35550 | MYC1 (AtBHLH012) interacts with TT2. |
| BIND | AT5G40330 | MYC1 (AtBHLH012) interacts with AtMYB23. |
| BIND | AT5G52600 | MYC1 (AtBHLH012) interacts with MYB82. |
| Annotation --
Nucleotide ? help
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| Source |
Hit ID |
E-value |
Description |
| GenBank | AB493664 | 0.0 | AB493664.1 Arabidopsis thaliana At4g00480 mRNA for hypothetical protein, partial cds, clone: RAAt4g00480. |
| Publications
? help Back to Top |
- Riechmann JL, et al.
Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
Science, 2000. 290(5499): p. 2105-10
[PMID:11118137] - Heim MA, et al.
The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity.
Mol. Biol. Evol., 2003. 20(5): p. 735-47
[PMID:12679534] - Toledo-Ortiz G,Huq E,Quail PH
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell, 2003. 15(8): p. 1749-70
[PMID:12897250] - Ramsay NA,Walker AR,Mooney M,Gray JC
Two basic-helix-loop-helix genes (MYC-146 and GL3) from Arabidopsis can activate anthocyanin biosynthesis in a white-flowered Matthiola incana mutant.
Plant Mol. Biol., 2003. 52(3): p. 679-88
[PMID:12956536] - Folta KM,Pontin MA,Karlin-Neumann G,Bottini R,Spalding EP
Genomic and physiological studies of early cryptochrome 1 action demonstrate roles for auxin and gibberellin in the control of hypocotyl growth by blue light.
Plant J., 2003. 36(2): p. 203-14
[PMID:14535885] - Bailey PC, et al.
Update on the basic helix-loop-helix transcription factor gene family in Arabidopsis thaliana.
Plant Cell, 2003. 15(11): p. 2497-502
[PMID:14600211] - Baudry A, et al.
TT2, TT8, and TTG1 synergistically specify the expression of BANYULS and proanthocyanidin biosynthesis in Arabidopsis thaliana.
Plant J., 2004. 39(3): p. 366-80
[PMID:15255866] - Zimmermann IM,Heim MA,Weisshaar B,Uhrig JF
Comprehensive identification of Arabidopsis thaliana MYB transcription factors interacting with R/B-like BHLH proteins.
Plant J., 2004. 40(1): p. 22-34
[PMID:15361138] - Morohashi K,Grotewold E
A systems approach reveals regulatory circuitry for Arabidopsis trichome initiation by the GL3 and GL1 selectors.
PLoS Genet., 2009. 5(2): p. e1000396
[PMID:19247443] - Hichri I, et al.
The basic helix-loop-helix transcription factor MYC1 is involved in the regulation of the flavonoid biosynthesis pathway in grapevine.
Mol Plant, 2010. 3(3): p. 509-23
[PMID:20118183] - Symonds VV,Hatlestad G,Lloyd AM
Natural allelic variation defines a role for ATMYC1: trichome cell fate determination.
PLoS Genet., 2011. 7(6): p. e1002069
[PMID:21695236] - Bruex A, et al.
A gene regulatory network for root epidermis cell differentiation in Arabidopsis.
PLoS Genet., 2012. 8(1): p. e1002446
[PMID:22253603] - Zhao H, et al.
A single amino acid substitution in IIIf subfamily of basic helix-loop-helix transcription factor AtMYC1 leads to trichome and root hair patterning defects by abolishing its interaction with partner proteins in Arabidopsis.
J. Biol. Chem., 2012. 287(17): p. 14109-21
[PMID:22334670] - Pesch M,Schulthei
Mutual control of intracellular localisation of the patterning proteins AtMYC1, GL1 and TRY/CPC in Arabidopsis.
Development, 2013. 140(16): p. 3456-67
[PMID:23900543] - Urao T,Yamaguchi-Shinozaki K,Mitsukawa N,Shibata D,Shinozaki K
Molecular cloning and characterization of a gene that encodes a MYC-related protein in Arabidopsis.
Plant Mol. Biol., 1996. 32(3): p. 571-6
[PMID:8980509]
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