PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT2G42280.1
Common NameAKS3, BHLH130, EN69, FBH4, T24P15.19
Organism
Arabidopsis thaliana
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family bHLH
Protein Properties Length: 359aa    MW: 39907.7 Da    PI: 7.9312
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AT2G42280.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH38.81.7e-12291336655
                  HHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
          HLH   6 nerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                  +++Er RR ri +++ +L+el+P+     +k  + +++L +Av+YIk+Lq
  AT2G42280.1 291 SIAERVRRTRISERMRKLQELVPNM----DKQTNTSDMLDLAVDYIKDLQ 336
                  689*********************7....688*****************9 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5088814.9285335IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474592.62E-15288347IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000839.08E-12289338No hitNo description
Gene3DG3DSA:4.10.280.103.5E-13290346IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003536.9E-12291341IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000101.9E-9291336IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0045944Biological Processpositive regulation of transcription from RNA polymerase II promoter
GO:0048573Biological Processphotoperiodism, flowering
GO:0005634Cellular Componentnucleus
GO:0001046Molecular Functioncore promoter sequence-specific DNA binding
GO:0001228Molecular Functiontranscriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0046983Molecular Functionprotein dimerization activity
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000037anatomyshoot apex
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009005anatomyroot
PO:0009006anatomyshoot system
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0009052anatomyflower pedicel
PO:0020030anatomycotyledon
PO:0020038anatomypetiole
PO:0020100anatomyhypocotyl
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0025281anatomypollen
PO:0001054developmental stagevascular leaf senescent stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 359 aa     Download sequence    Send to blast
MDSNNHLYDP NPTGSGLLRF RSAPSSVLAA FVDDDKIGFD SDRLLSRFVT SNGVNGDLGS  60
PKFEDKSPVS LTNTSVSYAA TLPPPPQLEP SSFLGLPPHY PRQSKGIMNS VGLDQFLGIN  120
NHHTKPVESN LLRQSSSPAG MFTNLSDQNG YGSMRNLMNY EEDEESPSNS NGLRRHCSLS  180
SRPPSSLGML SQIPEIAPET NFPYSHWNDP SSFIDNLSSL KREAEDDGKL FLGAQNGESG  240
NRMQLLSHHL SLPKSSSTAS DMVSVDKYLQ LQDSVPCKIR AKRGCATHPR SIAERVRRTR  300
ISERMRKLQE LVPNMDKQTN TSDMLDLAVD YIKDLQRQYK ILNDNRANCK CMNKEKKSI
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.437260.0flower| root
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO1453609050.0
Genevisible267628_at0.0
Expression AtlasAT2G42280-
AtGenExpressAT2G42280-
ATTED-IIAT2G42280-
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00308DAP27203113Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT2G42280.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Interaction ? help Back to Top
Source Intact With
BioGRIDAT1G14920
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT2G42280
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAK2289810.0AK228981.1 Arabidopsis thaliana mRNA for putative bHLH transcription factor, complete cds, clone: RAFL16-28-L05.
GenBankBT0153390.0BT015339.1 Arabidopsis thaliana At2g42280 gene, complete cds.
GenBankBT0157120.0BT015712.1 Arabidopsis thaliana At2g42280 gene, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_181757.20.0basic helix-loop-helix (bHLH) DNA-binding superfamily protein
SwissprotQ66GR30.0BH130_ARATH; Transcription factor bHLH130
TrEMBLA0A178VVH50.0A0A178VVH5_ARATH; FBH4
STRINGAT2G42280.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM62932745
Representative plantOGRP5111580
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Heim MA, et al.
    The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity.
    Mol. Biol. Evol., 2003. 20(5): p. 735-47
    [PMID:12679534]
  3. Toledo-Ortiz G,Huq E,Quail PH
    The Arabidopsis basic/helix-loop-helix transcription factor family.
    Plant Cell, 2003. 15(8): p. 1749-70
    [PMID:12897250]
  4. Bailey PC, et al.
    Update on the basic helix-loop-helix transcription factor gene family in Arabidopsis thaliana.
    Plant Cell, 2003. 15(11): p. 2497-502
    [PMID:14600211]
  5. Ikeda Y,Banno H,Niu QW,Howell SH,Chua NH
    The ENHANCER OF SHOOT REGENERATION 2 gene in Arabidopsis regulates CUP-SHAPED COTYLEDON 1 at the transcriptional level and controls cotyledon development.
    Plant Cell Physiol., 2006. 47(11): p. 1443-56
    [PMID:17056621]
  6. Soitamo AJ,Piippo M,Allahverdiyeva Y,Battchikova N,Aro EM
    Light has a specific role in modulating Arabidopsis gene expression at low temperature.
    BMC Plant Biol., 2008. 8: p. 13
    [PMID:18230142]
  7. Reiland S, et al.
    Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks.
    Plant Physiol., 2009. 150(2): p. 889-903
    [PMID:19376835]
  8. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  9. Ito S, et al.
    FLOWERING BHLH transcriptional activators control expression of the photoperiodic flowering regulator CONSTANS in Arabidopsis.
    Proc. Natl. Acad. Sci. U.S.A., 2012. 109(9): p. 3582-7
    [PMID:22334645]
  10. Efroni I, et al.
    Regulation of leaf maturation by chromatin-mediated modulation of cytokinin responses.
    Dev. Cell, 2013. 24(4): p. 438-45
    [PMID:23449474]
  11. Mar
    Large-scale identification of gibberellin-related transcription factors defines group VII ETHYLENE RESPONSE FACTORS as functional DELLA partners.
    Plant Physiol., 2014. 166(2): p. 1022-32
    [PMID:25118255]