PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AT2G21320.1

Common Name

BBX18, DBB1A, F3K23.8, STH4

Organism

Arabidopsis thaliana

Taxonomic ID

3702

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

DBB

Protein Properties

Length: 172aa MW: 18891 Da PI: 6.1028

Description

DBB family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT2G21320.1	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-B_box	19.7	1.7e-06	4	34	5	35
zf-B_box 5 kCpeHeekelqlfCedCqqllCedClleeHk 35 C+ +e+ ++ fC ++ lC +C ++ Hk AT2G21320.1 4 LCDACESAAAIVFCAADEAALCCSCDEKVHK 34 6***************************995 PP
2	zf-B_box	28	4.5e-09	52	92	2	38
zf-B_box 2 eerkCpeHeekelqlfCedCqqllCedClleeHkg....Ht 38 +++ C+ +e+ ++ ++Ce +++ lC +C + H g H+ AT2G21320.1 52 NAPSCDICENAPAFFYCEIDGSSLCLQCDMVVHVGgkrtHR 92 7899*****************************66666776 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS50119	10.239	1	47	IPR000315	B-box-type zinc finger
CDD	cd00021	6.25E-5	3	34	No hit	No description
SMART	SM00336	3.0E-5	4	47	IPR000315	B-box-type zinc finger
SMART	SM00336	1.8E-13	51	96	IPR000315	B-box-type zinc finger
PROSITE profile	PS50119	9.3	51	96	IPR000315	B-box-type zinc finger
Pfam	PF00643	5.1E-7	52	92	IPR000315	B-box-type zinc finger
CDD	cd00021	1.06E-7	54	96	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0010100	Biological Process	negative regulation of photomorphogenesis
GO:0070370	Biological Process	cellular heat acclimation
GO:0071483	Biological Process	cellular response to blue light
GO:0005634	Cellular Component	nucleus
GO:0000989	Molecular Function	transcription factor activity, transcription factor binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0008270	Molecular Function	zinc ion binding

Plant Ontology ? help Back to Top
PO Term	PO Category	PO Description
PO:0000013	anatomy	cauline leaf
PO:0000037	anatomy	shoot apex
PO:0000230	anatomy	inflorescence meristem
PO:0000293	anatomy	guard cell
PO:0008019	anatomy	leaf lamina base
PO:0009006	anatomy	shoot system
PO:0009009	anatomy	plant embryo
PO:0009010	anatomy	seed
PO:0009025	anatomy	vascular leaf
PO:0009029	anatomy	stamen
PO:0009030	anatomy	carpel
PO:0009031	anatomy	sepal
PO:0009032	anatomy	petal
PO:0009046	anatomy	flower
PO:0009047	anatomy	stem
PO:0009052	anatomy	flower pedicel
PO:0020030	anatomy	cotyledon
PO:0020100	anatomy	hypocotyl
PO:0025022	anatomy	collective leaf structure
PO:0025281	anatomy	pollen
PO:0001054	developmental stage	vascular leaf senescent stage
PO:0001078	developmental stage	plant embryo cotyledonary stage
PO:0001081	developmental stage	mature plant embryo stage
PO:0001185	developmental stage	plant embryo globular stage
PO:0004507	developmental stage	plant embryo bilateral stage
PO:0007098	developmental stage	LP.02 two leaves visible stage
PO:0007115	developmental stage	LP.04 four leaves visible stage
PO:0007123	developmental stage	LP.06 six leaves visible stage
PO:0007611	developmental stage	petal differentiation and expansion stage
PO:0007616	developmental stage	flowering stage

Sequence ? help Back to Top
Protein Sequence Length: 172 aa Download sequence Send to blast
MRILCDACES AAAIVFCAAD EAALCCSCDE KVHKCNKLAS RHLRVGLADP SNAPSCDICE 60 NAPAFFYCEI DGSSLCLQCD MVVHVGGKRT HRRFLLLRQR IEFPGDKPNH ADQLGLRCQK 120 ASSGRGQESN GNGDHDHNMI DLNSNPQRVH EPGSHNQEEG IDVNNANNHE HE

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
At.27367	0.0	flower

Expression -- Microarray ? help Back to Top
Source	ID	E-value
Genevisible	263739_at	0.0
Expression Atlas	AT2G21320	-
AtGenExpress	AT2G21320	-
ATTED-II	AT2G21320	-

Expression -- Description ? help Back to Top
Source	Description
Uniprot	TISSUE SPECIFICITY: Expressed in vasculature of leaves and petioles. {ECO:0000269\|PubMed:20872270}.

Functional Description ? help Back to Top
Source	Description
UniProt	Acts as negative regulator of seedling photomorphogenesis (PubMed:18540109). Acts as a negative regulator of blue light-mediated inhibition of hypocotyl elongation through increase of bioactive gibberellin levels (PubMed:20872270). Acts as a repressor of thermotolerance by modulating expression of a set of heat shock-responsive genes (PubMed:23238922). {ECO:0000269\|PubMed:18540109, ECO:0000269\|PubMed:20872270, ECO:0000269\|PubMed:23238922}.

Function -- GeneRIF ? help Back to Top
DBB1a promotes hypocotyl elongation under blue light condition through an increase in bioactive gibberellin levels in Arabidopsis.[DBB1a] [PMID: 20872270] Heat stress-induced BBX18 negatively regulates the thermotolerance in Arabidopsis. [BBX18] [PMID: 23238922]

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT2G21320.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By blue light (PubMed:20872270) and heat shock (at protein level) (PubMed:23238922). {ECO:0000269\|PubMed:20872270, ECO:0000269\|PubMed:23238922}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT2G21320

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AY060570	0.0	AY060570.1 Arabidopsis thaliana At2g21320/F3K23.8 mRNA, complete cds.
GenBank	AY125573	0.0	AY125573.1 Arabidopsis thaliana At2g21320/F3K23.8 mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_565507.1	1e-124	B-box zinc finger family protein
Swissprot	Q9SJU5	1e-125	BBX18_ARATH; B-box zinc finger protein 18
TrEMBL	D7LL26	1e-115	D7LL26_ARALL; Zinc finger (B-box type) family protein
STRING	AT2G21320.1	1e-124	(Arabidopsis thaliana)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM2168	24	69
Representative plant	OGRP3352	16	28

Link Out ? help Back to Top
Phytozome	AT2G21320.1
Entrez Gene	816671
iHOP	AT2G21320
wikigenes	AT2G21320

Publications ? help Back to Top
Riechmann JL, et al. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] Yamada K, et al. Empirical analysis of transcriptional activity in the Arabidopsis genome. Science, 2003. 302(5646): p. 842-6 [PMID:14593172] Rizhsky L,Davletova S,Liang H,Mittler R The zinc finger protein Zat12 is required for cytosolic ascorbate peroxidase 1 expression during oxidative stress in Arabidopsis. J. Biol. Chem., 2004. 279(12): p. 11736-43 [PMID:14722088] S ABA activates ADPR cyclase and cADPR induces a subset of ABA-responsive genes in Arabidopsis. Plant J., 2004. 38(3): p. 381-95 [PMID:15086800] Tepperman JM, et al. Expression profiling of phyB mutant demonstrates substantial contribution of other phytochromes to red-light-regulated gene expression during seedling de-etiolation. Plant J., 2004. 38(5): p. 725-39 [PMID:15144375] Stanley Kim H, et al. Transcriptional divergence of the duplicated oxidative stress-responsive genes in the Arabidopsis genome. Plant J., 2005. 41(2): p. 212-20 [PMID:15634198] Casson S,Spencer M,Walker K,Lindsey K Laser capture microdissection for the analysis of gene expression during embryogenesis of Arabidopsis. Plant J., 2005. 42(1): p. 111-23 [PMID:15773857] Spencer MW,Casson SA,Lindsey K Transcriptional profiling of the Arabidopsis embryo. Plant Physiol., 2007. 143(2): p. 924-40 [PMID:17189330] Willems G, et al. The genetic basis of zinc tolerance in the metallophyte Arabidopsis halleri ssp. halleri (Brassicaceae): an analysis of quantitative trait loci. Genetics, 2007. 176(1): p. 659-74 [PMID:17409091] Wohlbach DJ,Quirino BF,Sussman MR Analysis of the Arabidopsis histidine kinase ATHK1 reveals a connection between vegetative osmotic stress sensing and seed maturation. Plant Cell, 2008. 20(4): p. 1101-17 [PMID:18441212] Kumagai T, et al. The common function of a novel subfamily of B-Box zinc finger proteins with reference to circadian-associated events in Arabidopsis thaliana. Biosci. Biotechnol. Biochem., 2008. 72(6): p. 1539-49 [PMID:18540109] Datta S, et al. LZF1/SALT TOLERANCE HOMOLOG3, an Arabidopsis B-box protein involved in light-dependent development and gene expression, undergoes COP1-mediated ubiquitination. Plant Cell, 2008. 20(9): p. 2324-38 [PMID:18796637] Khanna R, et al. The Arabidopsis B-box zinc finger family. Plant Cell, 2009. 21(11): p. 3416-20 [PMID:19920209] Wang Q, et al. DBB1a, involved in gibberellin homeostasis, functions as a negative regulator of blue light-mediated hypocotyl elongation in Arabidopsis. Planta, 2011. 233(1): p. 13-23 [PMID:20872270] Yamawaki S,Yamashino T,Nakamichi N,Nakanishi H,Mizuno T Light-responsive double B-box containing transcription factors are conserved in Physcomitrella patens. Biosci. Biotechnol. Biochem., 2011. 75(10): p. 2037-41 [PMID:21979077] Ingkasuwan P, et al. Inferring transcriptional gene regulation network of starch metabolism in Arabidopsis thaliana leaves using graphical Gaussian model. BMC Syst Biol, 2012. 6: p. 100 [PMID:22898356] Wang Q,Tu X,Zhang J,Chen X,Rao L Heat stress-induced BBX18 negatively regulates the thermotolerance in Arabidopsis. Mol. Biol. Rep., 2013. 40(3): p. 2679-88 [PMID:23238922] Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Zhang X,Lin R Light signaling differentially regulates the expression of group IV of the B-box zinc finger family. Plant Signal Behav, 2017. 12(9): p. e1365213 [PMID:28922622]