PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

TCP

Protein Properties

Length: 359aa MW: 40754.4 Da PI: 5.0871

Description

TCP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT1G67260.1	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	TCP	129.4	3.6e-40	85	239	2	135
TCP 2 agkkdrhskihTkvggRdRRvRlsaecaarfFdLqdeLGfdkdsktieWLlqqakpaikeltgt...ssssa...sec.......eaesssssasnss 86 +kkdrhski T++g RdRRvRls+ +a++fFdLqd+LGfdk+skt++WLl+++ +aike ++ + + + e+e+++++++n AT1G67260.1 85 VVKKDRHSKIQTAQGIRDRRVRLSIGIARQFFDLQDMLGFDKASKTLDWLLKKSRKAIKEVVQAknlN---NddeD-FgniggdvEQEEEKEEDDN-- 176 589***********************************************************5552...42321.2344433244444444443.. PP TCP 87 sg..............kaaksaakskksqksaasalnlak.esrakarararertrekmriknk 135 g ++ +a++ +k++++ +n++ akar +a+ert+e m+ +n AT1G67260.1 177 -GdksfvyglspgygeEEVVCEATKAGIRKKKSELRNISSkGLGAKARGKAKERTKEMMAYDNP 239 .1345889999999985555555555555555556777664677*************98865 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Pfam	PF03634	1.9E-37	87	234	IPR005333	Transcription factor, TCP
PROSITE profile	PS51369	34.218	87	145	IPR017887	Transcription factor TCP subgroup
PROSITE profile	PS51370	8.677	216	233	IPR017888	CYC/TB1, R domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0009908	Biological Process	flower development
GO:0005634	Cellular Component	nucleus
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Plant Ontology ? help Back to Top
PO Term	PO Category	PO Description
PO:0000229	anatomy	flower meristem
PO:0007601	developmental stage	floral organ meristem development stage
PO:0007602	developmental stage	floral organ primordium development stage

Sequence ? help Back to Top
Protein Sequence Length: 359 aa Download sequence Send to blast
MSSSTNDYND GNNNGVYPLS LYLSSLSGHQ DIIHNPYNHQ LKASPGHMVS AVPESLIDYM 60 AFKSNNVVNQ QGFEFPEVSK EIKKVVKKDR HSKIQTAQGI RDRRVRLSIG IARQFFDLQD 120 MLGFDKASKT LDWLLKKSRK AIKEVVQAKN LNNDDEDFGN IGGDVEQEEE KEEDDNGDKS 180 FVYGLSPGYG EEEVVCEATK AGIRKKKSEL RNISSKGLGA KARGKAKERT KEMMAYDNPE 240 TASDITQSEI MDPFKRSIVF NEGEDMTHLF YKEPIEEFDN QESILTNMTL PTKMGQSYNQ 300 NNGILMLVDQ SSSSNYNTFL PQNLDYSYDQ NPFHDQTLYV VTDKNFPKGK VWIQDSFVN

Sequence ? help Back to Top

Protein Sequence Length: 359 aa Download sequence Send to blast

MSSSTNDYND GNNNGVYPLS LYLSSLSGHQ DIIHNPYNHQ LKASPGHMVS AVPESLIDYM  60
AFKSNNVVNQ QGFEFPEVSK EIKKVVKKDR HSKIQTAQGI RDRRVRLSIG IARQFFDLQD  120
MLGFDKASKT LDWLLKKSRK AIKEVVQAKN LNNDDEDFGN IGGDVEQEEE KEEDDNGDKS  180
FVYGLSPGYG EEEVVCEATK AGIRKKKSEL RNISSKGLGA KARGKAKERT KEMMAYDNPE  240
TASDITQSEI MDPFKRSIVF NEGEDMTHLF YKEPIEEFDN QESILTNMTL PTKMGQSYNQ  300
NNGILMLVDQ SSSSNYNTFL PQNLDYSYDQ NPFHDQTLYV VTDKNFPKGK VWIQDSFVN

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5zkt_A	1e-13	92	145	1	54	Putative transcription factor PCF6
5zkt_B	1e-13	92	145	1	54	Putative transcription factor PCF6
Search in ModeBase

Expression -- Microarray ? help Back to Top
Source	ID
Expression Atlas	AT1G67260
AtGenExpress	AT1G67260

Expression -- Description ? help Back to Top
Source	Description
Uniprot	DEVELOPMENTAL STAGE: Expressed transiently in early stages of floral meristems development but continuously in axillary shoot meristems, specifically in the dorsal part (adaxial). {ECO:0000269\|PubMed:11470410}.
Uniprot	TISSUE SPECIFICITY: Axillary shoot and floral meristems. {ECO:0000269\|PubMed:11470410}.

Functional Description ? help Back to Top
Source	Description
TAIR	Encodes protein with TCP (TB1,CYC,PCF) domain which is likely to be involved in DNA binding and protein-protein interactions. Based on genome analysis, there is a 9-member gene family that possesses this domain in Arabidopsis. Orthologue of Antirrhinum gene CYCLOIDEA.
UniProt	Involved in petal morphogenesis. {ECO:0000269\|PubMed:17940055}.

Function -- GeneRIF ? help Back to Top
TCP1 positively regulates the expression of the key brassinosteroid biosynthetic gene, DWF4. [PMID: 20435901] important roles of Arabidopsis TCP1 in the longitudinal elongation of petioles, rosette leaves and inflorescent stems [PMID: 20944404] TCP1 positively regulates BR biosynthesis via its direct regulation of the transcription of DWF4. [PMID: 21822059] Data indicate that transcription factors TCP-NGA regulatory interaction is likely conserved in angiosperms, including important crop species. [PMID: 25625546] TCP1 Modulates DWF4 Expression via Directly Interacting with the GGNCCC Motifs in the Promoter Region of DWF4 in Arabidopsis thaliana [PMID: 26233893]

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00215	DAP	27203113	Download

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT1G67260.1

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source	Target Gene (A: Activate/R: Repress)
ATRM	AT3G50660(A)

Regulation -- Hormone ? help Back to Top
Source	Hormone
AHD	Brassinosteroid

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT1G67260

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AC002130	0.0	AC002130.2 Genomic sequence for Arabidopsis thaliana BAC F1N21 from chromosome I, complete sequence.
GenBank	CP002684	0.0	CP002684.1 Arabidopsis thaliana chromosome 1 sequence.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_001077781.1	0.0	TCP family transcription factor
Swissprot	Q9FYG7	0.0	TCP1_ARATH; Transcription factor TCP1
TrEMBL	F4HRT7	0.0	F4HRT7_ARATH; TCP family transcription factor
STRING	AT1G67260.1	0.0	(Arabidopsis thaliana)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM6733	27	44
Representative plant	OGRP180	15	163

Link Out ? help Back to Top
Phytozome	AT1G67260.1
Entrez Gene	3767658
iHOP	AT1G67260
wikigenes	AT1G67260

Publications ? help Back to Top
Cubas P,Lauter N,Doebley J,Coen E The TCP domain: a motif found in proteins regulating plant growth and development. Plant J., 1999. 18(2): p. 215-22 [PMID:10363373] Riechmann JL, et al. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] Cubas P,Coen E,Zapater JM Ancient asymmetries in the evolution of flowers. Curr. Biol., 2001. 11(13): p. 1050-2 [PMID:11470410] Citerne HL,Luo D,Pennington RT,Coen E,Cronk QC A phylogenomic investigation of CYCLOIDEA-like TCP genes in the Leguminosae. Plant Physiol., 2003. 131(3): p. 1042-53 [PMID:12644657] Damerval C,Le Guilloux M,Jager M,Charon C Diversity and evolution of CYCLOIDEA-like TCP genes in relation to flower development in Papaveraceae. Plant Physiol., 2007. 143(2): p. 759-72 [PMID:17189327] Aguilar-Martínez JA,Poza-Carrión C,Cubas P Arabidopsis BRANCHED1 acts as an integrator of branching signals within axillary buds. Plant Cell, 2007. 19(2): p. 458-72 [PMID:17307924] Finlayson SA Arabidopsis Teosinte Branched1-like 1 regulates axillary bud outgrowth and is homologous to monocot Teosinte Branched1. Plant Cell Physiol., 2007. 48(5): p. 667-77 [PMID:17452340] Busch A,Zachgo S Control of corolla monosymmetry in the Brassicaceae Iberis amara. Proc. Natl. Acad. Sci. U.S.A., 2007. 104(42): p. 16714-9 [PMID:17940055] Guo Z, et al. TCP1 modulates brassinosteroid biosynthesis by regulating the expression of the key biosynthetic gene DWARF4 in Arabidopsis thaliana. Plant Cell, 2010. 22(4): p. 1161-73 [PMID:20435901] Koyama T,Sato F,Ohme-Takagi M A role of TCP1 in the longitudinal elongation of leaves in Arabidopsis. Biosci. Biotechnol. Biochem., 2010. 74(10): p. 2145-7 [PMID:20944404] An J,Guo Z,Gou X,Li J TCP1 positively regulates the expression of DWF4 in Arabidopsis thaliana. Plant Signal Behav, 2011. 6(8): p. 1117-8 [PMID:21822059] Yang X, et al. Evolution of double positive autoregulatory feedback loops in CYCLOIDEA2 clade genes is associated with the origin of floral zygomorphy. Plant Cell, 2012. 24(5): p. 1834-47 [PMID:22649271] Meinke DW A survey of dominant mutations in Arabidopsis thaliana. Trends Plant Sci., 2013. 18(2): p. 84-91 [PMID:22995285] Efroni I, et al. Regulation of leaf maturation by chromatin-mediated modulation of cytokinin responses. Dev. Cell, 2013. 24(4): p. 438-45 [PMID:23449474] Mar Large-scale identification of gibberellin-related transcription factors defines group VII ETHYLENE RESPONSE FACTORS as functional DELLA partners. Plant Physiol., 2014. 166(2): p. 1022-32 [PMID:25118255] Chen GH,Sun JY,Liu M,Liu J,Yang WC SPOROCYTELESS is a novel embryophyte-specific transcription repressor that interacts with TPL and TCP proteins in Arabidopsis. J Genet Genomics, 2014. 41(12): p. 617-25 [PMID:25527103] Ballester P,Navarrete-G Leaf expansion in Arabidopsis is controlled by a TCP-NGA regulatory module likely conserved in distantly related species. Physiol Plant, 2015. 155(1): p. 21-32 [PMID:25625546] Jin J, et al. An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors. Mol. Biol. Evol., 2015. 32(7): p. 1767-73 [PMID:25750178] Gao Y,Zhang D,Li J TCP1 Modulates DWF4 Expression via Directly Interacting with the GGNCCC Motifs in the Promoter Region of DWF4 in Arabidopsis thaliana. J Genet Genomics, 2015. 42(7): p. 383-92 [PMID:26233893] Mazur MJ, et al. Arabidopsis TCP Transcription Factors Interact with the SUMO Conjugating Machinery in Nuclear Foci. Front Plant Sci, 2017. 8: p. 2043 [PMID:29250092]