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Plant Transcription
Factor Database
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Transcription Factor Information
Basic
Information? help
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TF ID |
AT1G33240.1 |
Common Name | ATGTL1, AT-GTL1, GTL1 |
Organism |
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Taxonomic ID |
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Taxonomic Lineage |
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
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Family |
Trihelix |
Protein Properties |
Length: 669aa MW: 74212.7 Da PI: 5.8532 |
Description |
GT-2-like 1 |
Gene Model |
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Signature Domain? help Back to Top |
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No. |
Domain |
Score |
E-value |
Start |
End |
HMM Start |
HMM End |
1 | trihelix | 96.4 | 2.6e-30 | 62 | 146 | 1 | 87 |
trihelix 1 rWtkqevlaLiearremeerlrrgklkkplWeevskkmrergferspkqCkekwenlnkrykkikegekkrtsessstcpyfdqlea 87
rW+++e+laL+++r++m++++r++ lk+plWe+vs+k+ e g++rs+k+Ckek+en++k+yk++ke++++r++++ +++f+qlea
AT1G33240.1 62 RWPREETLALLRIRSDMDSTFRDATLKAPLWEHVSRKLLELGYKRSSKKCKEKFENVQKYYKRTKETRGGRHDGK--AYKFFSQLEA 146
8*********************************************************************86555..5******985 PP
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2 | trihelix | 104.3 | 9.1e-33 | 435 | 519 | 1 | 86 |
trihelix 1 rWtkqevlaLiearremeerlrrgklkkplWeevskkmrergferspkqCkekwenlnkrykkikegekkrtsessstcpyfdqle 86
rW+k e+laLi++r+ me r++++ k+ lWee+s m++ g++r++k+Ckekwen+nk+ykk+ke++kkr +++ +tcpyf++l+
AT1G33240.1 435 RWPKAEILALINLRSGMEPRYQDNVPKGLLWEEISTSMKRMGYNRNAKRCKEKWENINKYYKKVKESNKKR-PQDAKTCPYFHRLD 519
8*********************************************************************8.99999*******97 PP
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Gene Ontology ? help Back to Top |
GO Term |
GO Category |
GO Description |
GO:0008361 | Biological Process | regulation of cell size |
GO:0010090 | Biological Process | trichome morphogenesis |
GO:0030308 | Biological Process | negative regulation of cell growth |
GO:0032876 | Biological Process | negative regulation of DNA endoreduplication |
GO:0042631 | Biological Process | cellular response to water deprivation |
GO:0045892 | Biological Process | negative regulation of transcription, DNA-templated |
GO:2000037 | Biological Process | regulation of stomatal complex patterning |
GO:2000038 | Biological Process | regulation of stomatal complex development |
GO:0005634 | Cellular Component | nucleus |
GO:0003700 | Molecular Function | transcription factor activity, sequence-specific DNA binding |
GO:0043565 | Molecular Function | sequence-specific DNA binding |
Sequence ? help Back to Top |
Protein Sequence Length: 669 aa
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MEQGGGGGGN EVVEEASPIS SRPPANNLEE LMRFSAAADD GGLGGGGGGG GGGSASSSSG 60 NRWPREETLA LLRIRSDMDS TFRDATLKAP LWEHVSRKLL ELGYKRSSKK CKEKFENVQK 120 YYKRTKETRG GRHDGKAYKF FSQLEALNTT PPSSSLDVTP LSVANPILMP SSSSSPFPVF 180 SQPQPQTQTQ PPQTHNVSFT PTPPPLPLPS MGPIFTGVTF SSHSSSTASG MGSDDDDDDM 240 DVDQANIAGS SSRKRKRGNR GGGGKMMELF EGLVRQVMQK QAAMQRSFLE ALEKREQERL 300 DREEAWKRQE MARLAREHEV MSQERAASAS RDAAIISLIQ KITGHTIQLP PSLSSQPPPP 360 YQPPPAVTKR VAEPPLSTAQ SQSQQPIMAI PQQQILPPPP PSHPHAHQPE QKQQQQPQQE 420 MVMSSEQSSL PSSSRWPKAE ILALINLRSG MEPRYQDNVP KGLLWEEIST SMKRMGYNRN 480 AKRCKEKWEN INKYYKKVKE SNKKRPQDAK TCPYFHRLDL LYRNKVLGSG GGSSTSGLPQ 540 DQKQSPVTAM KPPQEGLVNV QQTHGSASTE EEEPIEESPQ GTEKPEDLVM RELIQQQQQL 600 QQQESMIGEY EKIEESHNYN NMEEEEDQEM DEEELDEDEK SAAFEIAFQS PANRGGNGHT 660 EPPFLTMVQ
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Nucleic Localization
Signal ? help
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No. |
Start |
End |
Sequence |
1 | 104 | 112 | KRSSKKCKE |
Expression --
Description ? help
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Source |
Description |
Uniprot | TISSUE SPECIFICITY: Mostly expressed in siliques, and, to a lower extent, in growing root hairs, leaves, stems, and flowers. Present in abaxial epidermal cells, predominantly in guard cells, pavement cells, and meristemoids. {ECO:0000269|PubMed:21169508, ECO:0000269|PubMed:9501260}. |
Functional Description ? help
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Source |
Description |
TAIR | Encodes a plant transcriptional activator that contains two separate, but similar, trihelix DNA-binding domains, similar to GT-2. Gene is expressed in all aerial parts of the plant, with higher level of expression in siliques. At-GTL2 was thought to be a duplicated copy of this gene but is likely to be a cloning artefact, the result of a chimeric clone. Regulates ploidy-dependent cell growth in trichome. |
UniProt | Transcription repressor that binds specific DNA sequence such as GT3 box 5'-GGTAAA-3' in the SDD1 promoter. Negative regulator of water use efficiency (WUE) via the promotion of stomatal density and distribution by the transcription repression of SDD1. Regulates the expression of several cell cycle genes and endoreduplication, especially in trichomes where it prevents ploidy-dependent plant cell growth. {ECO:0000269|PubMed:19717615, ECO:0000269|PubMed:21169508}. |
Function -- GeneRIF ? help
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- Study provides the genetic evidence for the requirement of transcriptional regulation in the repression of ploidy-dependent plant cell growth as well as for an involvement of GTL trihelix proteins in this regulation.
[PMID: 19717615] - Data identified Arabidopsis GT2-LIKE 1 (GTL1) as a transcriptional repressor of STOMATAL DENSITY AND DISTRIBUTION 1 (SDD1), a negative regulator of stomatal density.
[PMID: 21691149] - GTL1 actively terminates ploidy-dependent cell growth and its developmentally regulated expression is one of the key determinants of cell size in Arabidopsis leaf hair cells (trichomes).
[PMID: 23143274] - A trihelix transcription factor GT-2-LIKE1 (GTL1) and its homolog DF1 repress root hair growth. Transcriptional data, combined with genome-wide chromatin-binding data, show that GTL1 and DF1 directly bind the RSL4 promoter and regulate its expression to repress root hair growth.
[PMID: 29439132]
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Regulation -- Description ? help
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Source |
Description |
UniProt | INDUCTION: Down-regulated by water stress. {ECO:0000269|PubMed:21169508}. |
Annotation --
Nucleotide ? help
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Source |
Hit ID |
E-value |
Description |
GenBank | AC021045 | 0.0 | AC021045.2 Arabidopsis thaliana chromosome I BAC T9L6 genomic sequence, complete sequence. |
GenBank | AC027035 | 0.0 | AC027035.5 Arabidopsis thaliana chromosome 1 BAC T16O9 genomic sequence, complete sequence. |
GenBank | AJ003215 | 0.0 | AJ003215.1 Arabidopsis thaliana GTL1 gene. |
GenBank | CP002684 | 0.0 | CP002684.1 Arabidopsis thaliana chromosome 1 sequence. |
Publications
? help Back to Top |
- Riechmann JL, et al.
Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] - Thilmony R,Underwood W,He SY
Genome-wide transcriptional analysis of the Arabidopsis thaliana interaction with the plant pathogen Pseudomonas syringae pv. tomato DC3000 and the human pathogen Escherichia coli O157:H7. Plant J., 2006. 46(1): p. 34-53 [PMID:16553894] - Breuer C, et al.
The trihelix transcription factor GTL1 regulates ploidy-dependent cell growth in the Arabidopsis trichome. Plant Cell, 2009. 21(8): p. 2307-22 [PMID:19717615] - Yoo CY, et al.
The Arabidopsis GTL1 transcription factor regulates water use efficiency and drought tolerance by modulating stomatal density via transrepression of SDD1. Plant Cell, 2010. 22(12): p. 4128-41 [PMID:21169508] - Yoo CY,Hasegawa PM,Mickelbart MV
Regulation of stomatal density by the GTL1 transcription factor for improving water use efficiency. Plant Signal Behav, 2011. 6(7): p. 1069-71 [PMID:21691149] - Weng H,Yoo CY,Gosney MJ,Hasegawa PM,Mickelbart MV
Poplar GTL1 is a Ca2+/calmodulin-binding transcription factor that functions in plant water use efficiency and drought tolerance. PLoS ONE, 2012. 7(3): p. e32925 [PMID:22396800] - Breuer C, et al.
Transcriptional repression of the APC/C activator CCS52A1 promotes active termination of cell growth. EMBO J., 2012. 31(24): p. 4488-501 [PMID:23143274] - Caro E,Desvoyes B,Gutierrez C
GTL1 keeps cell growth and nuclear ploidy under control. EMBO J., 2012. 31(24): p. 4483-5 [PMID:23188085] - Jin J, et al.
An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors. Mol. Biol. Evol., 2015. 32(7): p. 1767-73 [PMID:25750178] - Zheng X, et al.
The Wheat GT Factor TaGT2L1D Negatively Regulates Drought Tolerance and Plant Development. Sci Rep, 2016. 6: p. 27042 [PMID:27245096] - Shibata M, et al.
GTL1 and DF1 regulate root hair growth through transcriptional repression of ROOT HAIR DEFECTIVE 6-LIKE 4 in Arabidopsis. Development, 2018. [PMID:29439132] - Smalle J, et al.
The trihelix DNA-binding motif in higher plants is not restricted to the transcription factors GT-1 and GT-2. Proc. Natl. Acad. Sci. U.S.A., 1998. 95(6): p. 3318-22 [PMID:9501260]
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