PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AA96G00078
Organism
Aethionema arabicum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Aethionemeae; Aethionema
Family E2F/DP
Protein Properties Length: 351aa    MW: 39627.9 Da    PI: 6.3284
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AA96G00078genomeVEGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP74.31.3e-231479171
     E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                rk+ksL+ll+++fl+l+++   +++ l+++a +L    v  +rRRiYDi+NVLe+++++++k+kn+++wkg
  AA96G00078 14 RKQKSLGLLCTNFLALYNRDGIEMIGLDDAAMKL---GV--ERRRIYDIVNVLESVGVLTRKAKNQYTWKG 79
                79*****************999************...**..****************************98 PP
2E2F_TDP811e-25149229171
     E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                 rkeksL+lltq+f+kl+ +s++++++l+e+ak L+ +      +++k+RR+YDi+NVL+++nliek     ++k++++w g
  AA96G00078 149 RKEKSLGLLTQNFIKLFVCSDNKTISLDEAAKLLLGDahntsIMRTKVRRLYDIANVLSSMNLIEKthtldSRKPAFKWLG 229
                 79***************************************999************************9999*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.2E-261080IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467853.09E-161377IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.0E-271479IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023193.0E-201579IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.106.1E-24145230IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013727.0E-34149229IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.5E-21150229IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467853.46E-14151230IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 351 aa     Download sequence    Send to blast
MPESSSSLHH SYSRKQKSLG LLCTNFLALY NRDGIEMIGL DDAAMKLGVE RRRIYDIVNV  60
LESVGVLTRK AKNQYTWKGF AAIPEALNEL KDEGVKDTFH RFYSNENVKT SDDEDDEEES  120
SQPYSSSQND NSKPDSLQQS SSSMKTDNRK EKSLGLLTQN FIKLFVCSDN KTISLDEAAK  180
LLLGDAHNTS IMRTKVRRLY DIANVLSSMN LIEKTHTLDS RKPAFKWLGY TGEPTFTLSS  240
DLKQTGSNKR VFGTDLTNVN VKRIKSTSST HEDATEKEPK MTNHTLAESS HDKNYAEESR  300
SYQFGPFTPT RGTNPTATLE DNSSRAFDVE NFDSAYRPTY QNQGEYTQIP I
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A8e-41132213228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapAA96G00078
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_013737731.20.0E2F transcription factor-like E2FE
RefseqXP_020880368.10.0E2F transcription factor-like E2FE isoform X1
SwissprotQ8LSZ40.0E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A078JSQ70.0A0A078JSQ7_BRANA; BnaCnng63530D protein (Fragment)
STRINGfgenesh2_kg.5__1169__AT3G48160.20.0(Arabidopsis lyrata)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM63042743
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.11e-171DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]