PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AA60G00193
Organism
Aethionema arabicum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Aethionemeae; Aethionema
Family E2F/DP
Protein Properties Length: 486aa    MW: 53110 Da    PI: 5.2248
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AA60G00193genomeVEGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP82.43.8e-26170235171
     E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                 r+++sL+llt+kf++ll++s++g+++ln++a++L   +v  ++RRiYDi+NVLe+++liek  kn+i wkg
  AA60G00193 170 RYDSSLGLLTKKFVNLLKHSKDGMLDLNKAAETL---EV--QKRRIYDITNVLEGIDLIEKPLKNRILWKG 235
                 6899******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.106.6E-28166237IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013729.2E-33170235IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.1E-16170233IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023197.1E-23172235IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146601.58E-47248351No hitNo description
SuperFamilySSF1440741.57E-32248351No hitNo description
PfamPF164212.8E-32251349IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 486 aa     Download sequence    Send to blast
MSGGVRSSPT PAQSRPPPSQ HLQHPPSTPS LPSSAPVVPP IRRHLAFAST KPPFHPSDDY  60
HRFAPCSLSN NDSSVASGSG VVDREEDAVV VRSPSRKRKS TIEGSTAPSN NGFVSSGLTS  120
IPNSPYQTPV SAKGSRVTSR SKVKGNRSTP QTPISNAGSP AALTPSGSCR YDSSLGLLTK  180
KFVNLLKHSK DGMLDLNKAA ETLEVQKRRI YDITNVLEGI DLIEKPLKNR ILWKGIDAMR  240
PGDVDADVSV LQADIENLSL KEQMLDNQIR DSEERLRDLS ENEKNQKWLF VTEEDIKSLP  300
GFQNQTLIAV KAPHGTTLEV PDPDEADYPQ RRYRIILRST MGPIDVYLVS EFEGKYEDPN  360
GSDAPAASLP IASSSGSTDN HDMETFTVDN TRTTIQHQAS QPPPDNTSDL NSLQDQVGGM  420
VKITHSVEND EADYWLLTGN DISMTDIWKT DSGFDWDYNI ADVSTPRAET PVMSKVPPAI  480
VDSTQR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A1e-22165236274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
19499SRKRKS
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00293DAPTransfer from AT2G36010Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapAA60G00193
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006410774.10.0transcription factor E2FA
SwissprotQ9FNY00.0E2FA_ARATH; Transcription factor E2FA
TrEMBLV4MAR90.0V4MAR9_EUTSA; Uncharacterized protein
STRINGXP_006410774.10.0(Eutrema salsugineum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM80828121
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.10.0E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]