PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

HD-ZIP

Protein Properties

Length: 860aa MW: 93937.7 Da PI: 6.0541

Description

HD-ZIP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
902559	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	Homeobox	57.4	2.4e-18	32	90	3	57
--SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHC....TS-HHHHHHHHHHHHHHHHC CS Homeobox 3 kRttftkeqleeLeelFeknrypsaeereeLAkkl....gLterqVkvWFqNrRakekk 57 k ++t+eq+e+Le+++ ++++ps +r++L +++ +++ +q+kvWFqNrR +ek+ 902559 32 KYVRYTPEQVEALERVYTECPKPSSLRRQQLIRECpilsNIEPKQIKVWFQNRRCREKQ 90 5678*****************************************************97 PP
2	START	191.2	5e-60	181	389	2	205
HHHHHHHHHHHHHHHC-TT-EEEEEXCCTTEEEEEEESSS.SCEEEEEEEECCSCHHHHHHHHHCCCGGCT-TT-SEEEEEEEECTT..EEEEEEEEXXTTXX CS START 2 laeeaaqelvkkalaeepgWvkssesengdevlqkfeeskvdsgealrasgvvdmvlallveellddkeqWdetlakaetlevissg..galqlmvaelqals 102 +aeea++e+++ka+ ++ Wv++ +++g++++ +++ s+++sg a+ra+g+v +++ v+e+l+d++ W ++++ ++tl vi g g+++l++++++a++ 902559 181 IAEEALAEFLSKATGTAVDWVQMIGMKPGPDSIGIVAISRNCSGIAARACGLVSLEPM-KVAEILKDRPSWLRDCRCVDTLSVIPAGngGTIELIYTQMYAPT 282 799*****************************************************.8888888888*************999********** PP -SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--....-TTSEE-EESSEEEEEEEECTCEEEEEEEE-EE--SSXXHHHHHHHHHHHHHHHHHHHHHHTX CS START 103 plvp.RdfvfvRyirqlgagdwvivdvSvdseqkppe...sssvvRaellpSgiliepksnghskvtwvehvdlkgrlphwllrslvksglaegaktwvatlq 201 +l++ Rdf+++Ry+ +l++g++v++++S++s + p+ sss+vRae++pSg+li+p+++g+s +++v+hvdl+++++++++r+l++s+ + ++k++va+l+ 902559 283 TLAAaRDFWTLRYSTCLEDGSYVVCERSITSATGGPTgppSSSFVRAEMRPSGFLIRPCEGGGSILHIVDHVDLDAWSVPEVMRPLYESSKILAQKMTVAALR 385 *****************************9999999************************************************************9 PP XXXX CS START 202 rqce 205 + ++ 902559 386 HVRQ 389 8765 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS50071	15.321	27	91	IPR001356	Homeobox domain
SMART	SM00389	5.7E-15	29	95	IPR001356	Homeobox domain
SuperFamily	SSF46689	8.55E-17	31	95	IPR009057	Homeodomain-like
CDD	cd00086	4.16E-16	32	92	No hit	No description
Pfam	PF00046	6.5E-16	33	90	IPR001356	Homeobox domain
Gene3D	G3DSA:1.10.10.60	2.1E-18	34	90	IPR009057	Homeodomain-like
CDD	cd14686	5.54E-6	84	123	No hit	No description
PROSITE profile	PS50848	27.201	171	399	IPR002913	START domain
CDD	cd08875	8.62E-76	175	391	No hit	No description
Gene3D	G3DSA:3.30.530.20	2.2E-22	179	385	IPR023393	START-like domain
SuperFamily	SSF55961	1.51E-36	180	392	No hit	No description
SMART	SM00234	2.4E-63	180	390	IPR002913	START domain
Pfam	PF01852	3.2E-57	181	389	IPR002913	START domain
SuperFamily	SSF55961	5.49E-6	428	509	No hit	No description
SuperFamily	SSF55961	5.49E-6	541	616	No hit	No description
Pfam	PF08670	2.5E-49	713	858	IPR013978	MEKHLA

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0009855	Biological Process	determination of bilateral symmetry
GO:0009944	Biological Process	polarity specification of adaxial/abaxial axis
GO:0010072	Biological Process	primary shoot apical meristem specification
GO:0080060	Biological Process	integument development
GO:0005634	Cellular Component	nucleus
GO:0003677	Molecular Function	DNA binding
GO:0008289	Molecular Function	lipid binding

Sequence ? help Back to Top
Protein Sequence Length: 860 aa Download sequence Send to blast
MNVSGGSLYS ETMMMVHTMN RESPDKGLDS GKYVRYTPEQ VEALERVYTE CPKPSSLRRQ 60 QLIRECPILS NIEPKQIKVW FQNRRCREKQ RKEAARLQTV NRKLNAMNKL LMEENDRLQK 120 QVSHLVYENG HMKQQLHTSS GTTTDNSCES VVVSGQQHQQ QNPNPQHLQR DANNPAGLLS 180 IAEEALAEFL SKATGTAVDW VQMIGMKPGP DSIGIVAISR NCSGIAARAC GLVSLEPMKV 240 AEILKDRPSW LRDCRCVDTL SVIPAGNGGT IELIYTQMYA PTTLAAARDF WTLRYSTCLE 300 DGSYVVCERS ITSATGGPTG PPSSSFVRAE MRPSGFLIRP CEGGGSILHI VDHVDLDAWS 360 VPEVMRPLYE SSKILAQKMT VAALRHVRQI AQETSGEVQY GGGRQPAVLR TFSQRLCRGF 420 NDAVNGFVDD GWSPMGSDGA EDITVMINLS PGKLCGSQYG NSFLPSFGSG VLCAKASMLL 480 QNVPPAVLVR FLREHRSEWA DYGVDAYAAA SLRASPFAVP CARAGGFPSN QVILPLAQTV 540 EHEESLEVVR LEGHAYSPED MGLARDMYLL QLCSGVDENV VGGCAQLVFA PIDESFADDA 600 PLLPSGFRII PLEQKSTPNG ASTNRTLDLA SALEGSTRQA GEADPNGCNF RSVLTIAFQF 660 TFDNHSRDSV ASMARQYVRS IVGSIQRVAL AIAPRPGSNI SPISVPTSPE ALTLVRWIAR 720 SYSLHTGADL FGSDSQTSGD TLLHQLWNHT DAILCCSLKT NASPVFTFAN QTGLDMLETT 780 LVALQDIMLD KTLDEPGRKA LCSEFPKIMQ QGYAHLPAGV CASSMGRMVS YEQATVWKVL 840 EDDESNHCLA FMFVNWSFV*

Sequence ? help Back to Top

Protein Sequence Length: 860 aa Download sequence Send to blast

MNVSGGSLYS ETMMMVHTMN RESPDKGLDS GKYVRYTPEQ VEALERVYTE CPKPSSLRRQ  60
QLIRECPILS NIEPKQIKVW FQNRRCREKQ RKEAARLQTV NRKLNAMNKL LMEENDRLQK  120
QVSHLVYENG HMKQQLHTSS GTTTDNSCES VVVSGQQHQQ QNPNPQHLQR DANNPAGLLS  180
IAEEALAEFL SKATGTAVDW VQMIGMKPGP DSIGIVAISR NCSGIAARAC GLVSLEPMKV  240
AEILKDRPSW LRDCRCVDTL SVIPAGNGGT IELIYTQMYA PTTLAAARDF WTLRYSTCLE  300
DGSYVVCERS ITSATGGPTG PPSSSFVRAE MRPSGFLIRP CEGGGSILHI VDHVDLDAWS  360
VPEVMRPLYE SSKILAQKMT VAALRHVRQI AQETSGEVQY GGGRQPAVLR TFSQRLCRGF  420
NDAVNGFVDD GWSPMGSDGA EDITVMINLS PGKLCGSQYG NSFLPSFGSG VLCAKASMLL  480
QNVPPAVLVR FLREHRSEWA DYGVDAYAAA SLRASPFAVP CARAGGFPSN QVILPLAQTV  540
EHEESLEVVR LEGHAYSPED MGLARDMYLL QLCSGVDENV VGGCAQLVFA PIDESFADDA  600
PLLPSGFRII PLEQKSTPNG ASTNRTLDLA SALEGSTRQA GEADPNGCNF RSVLTIAFQF  660
TFDNHSRDSV ASMARQYVRS IVGSIQRVAL AIAPRPGSNI SPISVPTSPE ALTLVRWIAR  720
SYSLHTGADL FGSDSQTSGD TLLHQLWNHT DAILCCSLKT NASPVFTFAN QTGLDMLETT  780
LVALQDIMLD KTLDEPGRKA LCSEFPKIMQ QGYAHLPAGV CASSMGRMVS YEQATVWKVL  840
EDDESNHCLA FMFVNWSFV*

Functional Description ? help Back to Top
Source	Description
UniProt	Probable transcription factor involved in the determination of adaxial-abaxial polarity in ovule primordium. Specifies adaxial leaf fates. {ECO:0000269\|PubMed:11395776, ECO:0000269\|PubMed:15328016, ECO:0000269\|PubMed:15598805}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	902559

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Repressed by miR165 and miR166. {ECO:0000269\|PubMed:14999284, ECO:0000269\|PubMed:16033795, ECO:0000269\|PubMed:17237362}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AJ441291	0.0	AJ441291.1 Arabidopsis thaliana mRNA for homeodomain-leucine zipper protein 14 (ATHB-14 gene).
GenBank	AY099791	0.0	AY099791.1 Arabidopsis thaliana homeodomain transcription factor (At2g34710) mRNA, complete cds.
GenBank	BT000335	0.0	BT000335.1 Arabidopsis thaliana homeodomain transcription factor (At2g34710) mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_020884308.1	0.0	homeobox-leucine zipper protein ATHB-14
Swissprot	O04291	0.0	ATB14_ARATH; Homeobox-leucine zipper protein ATHB-14
TrEMBL	D7LH38	0.0	D7LH38_ARALL; Uncharacterized protein
STRING	scaffold_402060.1	0.0	(Arabidopsis lyrata)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM4256	26	53

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G34710.1	0.0	HD-ZIP family protein

Link Out ? help Back to Top
Phytozome	902559
Entrez Gene	9317420

Publications ? help Back to Top
Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Jia X, et al. Functional plasticity of miR165/166 in plant development revealed by small tandem target mimic. Plant Sci., 2015. 233: p. 11-21 [PMID:25711809] Müller CJ, et al. PHABULOSA Mediates an Auxin Signaling Loop to Regulate Vascular Patterning in Arabidopsis. Plant Physiol., 2016. 170(2): p. 956-70 [PMID:26637548] Yamada T,Sasaki Y,Hashimoto K,Nakajima K,Gasser CS CORONA, PHABULOSA and PHAVOLUTA collaborate with BELL1 to confine WUSCHEL expression to the nucellus in Arabidopsis ovules. Development, 2016. 143(3): p. 422-6 [PMID:26700684] Kim ES, et al. HAWAIIAN SKIRT regulates the quiescent center-independent meristem activity in Arabidopsis roots. Physiol Plant, 2016. 157(2): p. 221-33 [PMID:26968317] Husbands AY,Aggarwal V,Ha T,Timmermans MC In Planta Single-Molecule Pull-Down Reveals Tetrameric Stoichiometry of HD-ZIPIII:LITTLE ZIPPER Complexes. Plant Cell, 2016. 28(8): p. 1783-94 [PMID:27385814] Di Ruocco G, et al. Differential spatial distribution of miR165/6 determines variability in plant root anatomy. Development, 2018. [PMID:29158439] Wójcik AM,Nodine MD,Gaj MD miR160 and miR166/165 Contribute to the LEC2-Mediated Auxin Response Involved in the Somatic Embryogenesis Induction in Arabidopsis. Front Plant Sci, 2017. 8: p. 2024 [PMID:29321785] Hashimoto K,Miyashima S,Sato-Nara K,Yamada T,Nakajima K Functionally Diversified Members of the MIR165/6 Gene Family Regulate Ovule Morphogenesis in Arabidopsis thaliana. Plant Cell Physiol., 2018. 59(5): p. 1017-1026 [PMID:29462472]