PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

676787872

Organism

Sisymbrium irio

Taxonomic ID

3730

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Sisymbrieae; Sisymbrium

Family

E2F/DP

Protein Properties

Length: 887aa MW: 98824 Da PI: 6.481

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
676787872	genome	VEGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	81.1	9.7e-26	550	615	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++l++++++g+++ln++a++L +v ++RRiYDi+NVLe+++liek kn+i wkg 676787872 550 RYDSSLGLLTKKFVNLIKQAKDGMLDLNKAAETL---EV--QKRRIYDITNVLEGIDLIEKPLKNRILWKG 615 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SMART	SM00733	2000	86	118	IPR003690	Transcription termination factor, mitochondrial/chloroplastic
SMART	SM00733	0.047	123	155	IPR003690	Transcription termination factor, mitochondrial/chloroplastic
Pfam	PF02536	1.6E-30	149	305	IPR003690	Transcription termination factor, mitochondrial/chloroplastic
SMART	SM00733	5.3E-4	161	192	IPR003690	Transcription termination factor, mitochondrial/chloroplastic
SMART	SM00733	1.1	195	222	IPR003690	Transcription termination factor, mitochondrial/chloroplastic
SMART	SM00733	4.7E-6	227	259	IPR003690	Transcription termination factor, mitochondrial/chloroplastic
SMART	SM00733	0.0026	260	291	IPR003690	Transcription termination factor, mitochondrial/chloroplastic
Gene3D	G3DSA:1.10.10.10	1.8E-27	546	616	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	2.9E-32	550	615	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	4.35E-16	550	613	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	1.7E-22	552	615	IPR003316	E2F/DP family, winged-helix DNA-binding domain
CDD	cd14660	5.09E-47	628	732	No hit	No description
SuperFamily	SSF144074	5.23E-32	629	732	No hit	No description
Pfam	PF16421	2.7E-32	632	730	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0045893	Biological Process	positive regulation of transcription, DNA-templated
GO:0051446	Biological Process	positive regulation of meiotic cell cycle
GO:0005667	Cellular Component	transcription factor complex
GO:0003690	Molecular Function	double-stranded DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 887 aa Download sequence Send to blast
MQQEALSFLS STFPSRHRFP PFSRLRFHNF PALSFKPNTS SSSSSSLFFP PQKSPDCSSF 60 PSNNETLETD IHEKLLYLDS LGIDFLALIN RHPPLLSAAL STVKSVVDYM TTPPINFTLP 120 DFRRLVSMCP ELLTSPLTSH TIPVITFLLR EVGVDSVFDL RQALRRRPRL LACSVDHQLR 180 PTLYFLQRLG ILDPHRHTYL LSCSVEHKLI PRIDYFHNLG FSRRSATAMF KRFPQLFNYS 240 IAENYEPKLE YLRVEMGRDV REVLEFPQYF SFSLENRIKP RHQACAEKGV RFPLPVMLKT 300 NEAGFRDTLE PEQSSFPPHL SQHKIPSFPR FLLSPFFLFL LSLSLSLTKT LVFPLPSSPI 360 AVPTLAAEIF QSDSALLRSM SGGVRSSPGP SHQPPPPPHN PPSSPSSAAS MPVVPPIRRH 420 LAFASTKPPF HPSDNYHRFT PSYLSNNNDR SSLVNNDCGI VDREDEAVVL RSPSRKRKST 480 MDVVTAPSSN GVSSSSGFTS IPNSPCQTPV SAKGGRVNIK SKAKGNQSIP QTPISNIGSP 540 ATLTPSGSCR YDSSLGLLTK KFVNLIKQAK DGMLDLNKAA ETLEVQKRRI YDITNVLEGI 600 DLIEKPLKNR ILWKGVDVAR PGDVDADVSV VQAEIENLSL EEQALDNQIR ETEERLRELS 660 ENEKNQKWLF VTEEDIKSLP GFQNQTLIAV KAPHGTTLEV PDPDEAVEHP QRRYRIILRS 720 TMGPIDVYLV SEFEGKFEDT NGPVAPAPCL PIASCSGSTE NHDIEALTVD NTGTAIEHHQ 780 VSQEHAHAQP GDTSDLNYLQ EQVGGMLKIT PSEVENDDTD YWLLSNAEIS MTDIWKTDSV 840 QCDIYIDMQS LTQAKAGIDW DYGIADVSTP PPVIGEISPT AINSTPR

Sequence ? help Back to Top

Protein Sequence Length: 887 aa Download sequence Send to blast

MQQEALSFLS STFPSRHRFP PFSRLRFHNF PALSFKPNTS SSSSSSLFFP PQKSPDCSSF  60
PSNNETLETD IHEKLLYLDS LGIDFLALIN RHPPLLSAAL STVKSVVDYM TTPPINFTLP  120
DFRRLVSMCP ELLTSPLTSH TIPVITFLLR EVGVDSVFDL RQALRRRPRL LACSVDHQLR  180
PTLYFLQRLG ILDPHRHTYL LSCSVEHKLI PRIDYFHNLG FSRRSATAMF KRFPQLFNYS  240
IAENYEPKLE YLRVEMGRDV REVLEFPQYF SFSLENRIKP RHQACAEKGV RFPLPVMLKT  300
NEAGFRDTLE PEQSSFPPHL SQHKIPSFPR FLLSPFFLFL LSLSLSLTKT LVFPLPSSPI  360
AVPTLAAEIF QSDSALLRSM SGGVRSSPGP SHQPPPPPHN PPSSPSSAAS MPVVPPIRRH  420
LAFASTKPPF HPSDNYHRFT PSYLSNNNDR SSLVNNDCGI VDREDEAVVL RSPSRKRKST  480
MDVVTAPSSN GVSSSSGFTS IPNSPCQTPV SAKGGRVNIK SKAKGNQSIP QTPISNIGSP  540
ATLTPSGSCR YDSSLGLLTK KFVNLIKQAK DGMLDLNKAA ETLEVQKRRI YDITNVLEGI  600
DLIEKPLKNR ILWKGVDVAR PGDVDADVSV VQAEIENLSL EEQALDNQIR ETEERLRELS  660
ENEKNQKWLF VTEEDIKSLP GFQNQTLIAV KAPHGTTLEV PDPDEAVEHP QRRYRIILRS  720
TMGPIDVYLV SEFEGKFEDT NGPVAPAPCL PIASCSGSTE NHDIEALTVD NTGTAIEHHQ  780
VSQEHAHAQP GDTSDLNYLQ EQVGGMLKIT PSEVENDDTD YWLLSNAEIS MTDIWKTDSV  840
QCDIYIDMQS LTQAKAGIDW DYGIADVSTP PPVIGEISPT AINSTPR

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	2e-22	545	616	2	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	473	478	SRKRKS

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00293	DAP	Transfer from AT2G36010	Download

Cis-element ? help Back to Top
Source	Link
PlantRegMap	676787872

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_006410774.1	0.0	transcription factor E2FA
Swissprot	Q9FNY0	0.0	E2FA_ARATH; Transcription factor E2FA
TrEMBL	A0A1J3DWC7	0.0	A0A1J3DWC7_NOCCA; Transcription factor E2FA (Fragment)
STRING	XP_006410774.1	0.0	(Eutrema salsugineum)
STRING	XP_006293941.1	0.0	(Capsella rubella)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM808	28	121

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	0.0	E2F transcription factor 3

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]