PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Sisymbrieae; Sisymbrium

Family

HD-ZIP

Protein Properties

Length: 298aa MW: 33066.6 Da PI: 4.3604

Description

HD-ZIP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
676752354	genome	VEGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	Homeobox	60.2	3.3e-19	53	106	3	56
--SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHHH CS Homeobox 3 kRttftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRakek 56 k+++++ eq+++Le+ Fe ++++ e++ +LA++lgL+ rqV +WFqNrRa++k 676752354 53 KKRRLSVEQVKALEKNFEIDNKLEPERKVKLAQELGLQPRQVAIWFQNRRARWK 106 56689************************************************9 PP
2	HD-ZIP_I/II	130.1	8.5e-42	52	144	1	93
HD-ZIP_I/II 1 ekkrrlskeqvklLEesFeeeekLeperKvelareLglqprqvavWFqnrRARtktkqlEkdyeaLkraydalkeenerLekeveeLreelke 93 ekkrrls eqvk+LE++Fe ++kLeperKv+la+eLglqprqva+WFqnrRAR+ktkqlE+dy +Lk+++dalk+++++L++++++L +e++e 676752354 52 EKKRRLSVEQVKALEKNFEIDNKLEPERKVKLAQELGLQPRQVAIWFQNRRARWKTKQLERDYGVLKSNFDALKRSRDSLQRDNDSLLAEIQE 144 69**************************************************************************************99987 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF46689	1.04E-19	45	110	IPR009057	Homeodomain-like
PROSITE profile	PS50071	17.702	48	108	IPR001356	Homeobox domain
SMART	SM00389	1.3E-18	51	112	IPR001356	Homeobox domain
CDD	cd00086	6.73E-19	53	109	No hit	No description
Pfam	PF00046	2.2E-16	53	106	IPR001356	Homeobox domain
Gene3D	G3DSA:1.10.10.60	2.6E-20	55	115	IPR009057	Homeodomain-like
PRINTS	PR00031	7.2E-6	79	88	IPR000047	Helix-turn-helix motif
PROSITE pattern	PS00027	0	83	106	IPR017970	Homeobox, conserved site
PRINTS	PR00031	7.2E-6	88	104	IPR000047	Helix-turn-helix motif
Pfam	PF02183	6.0E-18	108	149	IPR003106	Leucine zipper, homeobox-associated

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0009737	Biological Process	response to abscisic acid
GO:0045893	Biological Process	positive regulation of transcription, DNA-templated
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0042803	Molecular Function	protein homodimerization activity
GO:0043565	Molecular Function	sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 298 aa Download sequence Send to blast
MISSDNQLSP RPSATGFLYP STGDYSPMFD GLEDGSLEDI GVGHASSTAA AEKKRRLSVE 60 QVKALEKNFE IDNKLEPERK VKLAQELGLQ PRQVAIWFQN RRARWKTKQL ERDYGVLKSN 120 FDALKRSRDS LQRDNDSLLA EIQELRAKLD VDGTSGCNGN ALTEENGVVK AVETVAYQTV 180 MVNNDVVELS QRSSPPQPHI TTEAPASELA YEMFSIFPRA ESLREDPADS SDSSAVLNEE 240 YSPTAAEAAA ATAVEMSTMG CFSQYVKMEE HEDLFSGEEA CKLFADNEQW YCAGQWNS

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	100	108	RRARWKTKQ

Functional Description ? help Back to Top
Source	Description
UniProt	Probable transcription factor that acts as a positive regulator of ABA-responsiveness, mediating the inhibitory effect of ABA on growth during seedling establishment. Binds to the DNA sequence 5'-CAATNATTG-3'. {ECO:0000269\|PubMed:12678559}.

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00587	DAP	Transfer from AT5G65310	Download

Cis-element ? help Back to Top
Source	Link
PlantRegMap	676752354

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Down-regulated by abscisic acid (ABA) and by salt stress. {ECO:0000269\|PubMed:12678559, ECO:0000269\|PubMed:16055682}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AK353247	1e-144	AK353247.1 Thellungiella halophila mRNA, complete cds, clone: RTFL01-23-D07.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_009130506.1	0.0	PREDICTED: homeobox-leucine zipper protein ATHB-5-like
Refseq	XP_013678412.1	0.0	homeobox-leucine zipper protein ATHB-5-like
Swissprot	P46667	1e-155	ATHB5_ARATH; Homeobox-leucine zipper protein ATHB-5
TrEMBL	A0A078HKI1	0.0	A0A078HKI1_BRANA; BnaAnng04800D protein
TrEMBL	A0A3P6AX27	0.0	A0A3P6AX27_BRACM; Uncharacterized protein
STRING	Bra031866.1-P	0.0	(Brassica rapa)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM12986	15	26

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G65310.2	1e-157	homeobox protein 5

Publications ? help Back to Top
Cassan-Wang H, et al. Identification of novel transcription factors regulating secondary cell wall formation in Arabidopsis. Front Plant Sci, 2013. 4: p. 189 [PMID:23781226] Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Song L, et al. A transcription factor hierarchy defines an environmental stress response network. Science, 2017. [PMID:27811239] Stamm P, et al. The Transcription Factor ATHB5 Affects GA-Mediated Plasticity in Hypocotyl Cell Growth during Seed Germination. Plant Physiol., 2017. 173(1): p. 907-917 [PMID:27872245]