PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID 311286
Common NameARALYDRAFT_311286
Organism
Arabidopsis lyrata
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family MYB_related
Protein Properties Length: 1249aa    MW: 138306 Da    PI: 6.4635
Description MYB_related family protein
Gene Model
Gene Model ID Type Source Coding Sequence
311286genomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Myb_DNA-binding41.43.4e-1310591103147
                       TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHHH CS
  Myb_DNA-binding    1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqky 47  
                       r +WT++E++++++a +++  + Wk+I + +g  +t  q++s+ qky
           311286 1059 RENWTEQEHDKFLEALHLFDRD-WKKIEAFVG-SKTVIQIRSHAQKY 1103
                       789*****************77.*********.*************9 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd052994.76E-94352670No hitNo description
Gene3DG3DSA:3.40.50.7201.2E-5388459IPR016040NAD(P)-binding domain
SuperFamilySSF517352.43E-33447640IPR016040NAD(P)-binding domain
PfamPF028262.1E-27455637IPR006140D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
Gene3DG3DSA:3.40.50.7205.5E-39460642IPR016040NAD(P)-binding domain
SuperFamilySSF466899.72E-1610531109IPR009057Homeodomain-like
PROSITE profilePS5129415.50710541108IPR017930Myb domain
Gene3DG3DSA:1.10.10.606.3E-610571109IPR009057Homeodomain-like
TIGRFAMsTIGR015575.7E-1710571106IPR006447Myb domain, plants
SMARTSM007172.9E-1110581106IPR001005SANT/Myb domain
PfamPF002496.1E-1110591103IPR001005SANT/Myb domain
CDDcd001677.31E-810611104No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0000226Biological Processmicrotubule cytoskeleton organization
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0008360Biological Processregulation of cell shape
GO:0009965Biological Processleaf morphogenesis
GO:0010091Biological Processtrichome branching
GO:0010482Biological Processregulation of epidermal cell division
GO:0031129Biological Processinductive cell-cell signaling
GO:0042814Biological Processmonopolar cell growth
GO:0045604Biological Processregulation of epidermal cell differentiation
GO:0048444Biological Processfloral organ morphogenesis
GO:0048530Biological Processfruit morphogenesis
GO:0055114Biological Processoxidation-reduction process
GO:2000039Biological Processregulation of trichome morphogenesis
GO:0005634Cellular Componentnucleus
GO:0005802Cellular Componenttrans-Golgi network
GO:0005829Cellular Componentcytosol
GO:0003677Molecular FunctionDNA binding
GO:0042803Molecular Functionprotein homodimerization activity
GO:0051287Molecular FunctionNAD binding
Sequence ? help Back to Top
Protein Sequence    Length: 1249 aa     Download sequence    Send to blast
MISKDHNHHQ DPLGTTKSYN MKTSAVSPPP SSTSSIALSQ SAWLEVRLFY VRIAPCVVEN  60
VPDFLTLRHP RRETGASLEV NGVRVPSSQT ASLKLRRDRV DRESSEVTYV STETVRVTGC  120
VDFEVYDNDD MVLCGNLDRI EGAWNNGTVS DPKTGWGMDC YIAMGNGHVS GPSSSAFFQP  180
KLGVSSPSVE VYIAGCCGGV PVILTKTIQA SPRRKVARHV TLDAIPEDEE VGKEQDIGTI  240
GDELARQSKV QMMESEVDDY DESEMKMAQR YYPEGMYVDE DGQLSWFNAG VRVGVGIGLG  300
MCLGVGIGVG LLMRSYQATT SNLRRSEKKK EMSKIRSSAT MPHRDQPSPA SPHVVTLNCI  360
EDCALEQDSL AGVAGVEYVP LSRIADGKIE SATAVLLHSL AYLPRAAQRR LRPHQLILCL  420
GSADRAVDST LAADLGLRLV HVDTSRAEEI ADTVMALILG LLRRTHLLSR HALSASGWLG  480
SLQPLCRGMR RCRGMVLGIV GRSVSARYLA SRSLAFKMSV LYFDVPEGDE DRIRPSRFPR  540
AARRMDTLND LLAASDVISL HCALTDDTVQ ILNAECLQHI KPGAFLVNTG SCQLLDDCAV  600
KQLLIDGTIA GCALDGAEGP QWMEAWVKEM PNVLILPRSA DYSEEVWMEI REKAISILHS  660
FFLDGVIPSN TVSDEEIEES EASEEEEQSP IKHEKLAIVE STSRQQGEST LTSTEIVHRE  720
ASELKESLSP GQQHVSQNTA VKPEGRRSRS GKKAKKRHSQ QKYMQKAEGS SGLNEESTSR  780
RDDIAMSDTE EVLSSSSRCA SPEDSRSRKT PLEVMQESSP SQLVMSSKKF IGKSSELLKD  840
GYVVALYAKD LSGLHVSRQR TKNGGWFLDT LSNVSKRDPA AQFIIAYRNK DTVGLRSFAA  900
GGKLLQINRR MEFVFASHSF DVWESWSLEG SLDECRLVNC RNSSAVLDVR VEILAMVGDD  960
AETSDELVLE GRLLLFYGSG RDELESIVCL GSLCVFSRFM VTVNPSQAHC LPMSMNLPGY  1020
NTLAHTATTM PVSIRSNTMS FFEDPTKKIR KPYTITKSRE NWTEQEHDKF LEALHLFDRD  1080
WKKIEAFVGS KTVIQIRSHA QKYFLKVQKN GTKEHYLYST NSHPCKHGLV RSDVNIPTTV  1140
IKEELGGSEN CCSTTSSSRD KQRTRTVTET NDQESCGKPH RVTPNFAEVY SFIGSVFDPK  1200
TTGHVQRLKE MDPTNLETVL LLMRNLSVNL TSPEFEEQRM LISSYNAR*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1hku_A8e-333326549328C-TERMINAL BINDING PROTEIN 3
1hl3_A8e-333326549328C-TERMINAL BINDING PROTEIN 3
2hu2_A8e-333326549328C-terminal-binding protein 1
3ga0_A8e-333326549328C-terminal-binding protein 1
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1323329RRSEKKK
Functional Description ? help Back to Top
Source Description
UniProtInvolved in controlling the equilibrium between tubular and stacked structures in the Golgi complex (By similarity). Required for cortical microtubules (MTs) arrangement that confers cell shape. Regulates the width of leaves by controlling the polar elongation of leaf cells. Involved in the regulation of trichome branching. Seems to not be able to regulate gene transcription. Regulates epidermal cell divisions and elongation in a non-cell-autonomous manner (regulated by subepidermal cells), but regulates epidermal cell polarity, shape, trichome branching and elongation in a cell-autonomous manner. Negatively regulates growth in the petiole elongation. Prevents lipid peroxidation as a result of abiotic stress response. Is involved in the SUB-dependent signaling mechanism and may act in a membrane trafficking event around the trans-Golgi network. {ECO:0000250, ECO:0000269|PubMed:10572032, ECO:0000269|PubMed:11889033, ECO:0000269|PubMed:12079678, ECO:0000269|PubMed:17972097, ECO:0000269|PubMed:19843316, ECO:0000269|PubMed:23368817, ECO:0000269|PubMed:23672620, ECO:0000269|PubMed:8625845, ECO:0000269|PubMed:9736998}.
Cis-element ? help Back to Top
SourceLink
PlantRegMap311286
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAB0320600.0AB032060.1 Arabidopsis thaliana mRNA for C-terminal binding protein, complete cds.
GenBankY100860.0Y10086.1 Arabidopsis thaliana gene encoding putative dehydrogenase.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_012083311.10.0C-terminal binding protein AN
SwissprotO237020.0CTBP_ARATH; C-terminal binding protein AN
TrEMBLD7KQ660.0D7KQ66_ARALL; Uncharacterized protein
STRINGfgenesh1_pm.C_scaffold_10000660.0(Arabidopsis lyrata)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G01520.11e-149MYB_related family protein
Publications ? help Back to Top
  1. Kim GT, et al.
    The ANGUSTIFOLIA gene of Arabidopsis, a plant CtBP gene, regulates leaf-cell expansion, the arrangement of cortical microtubules in leaf cells and expression of a gene involved in cell-wall formation.
    EMBO J., 2002. 21(6): p. 1267-79
    [PMID:11889033]
  2. Folkers U, et al.
    The cell morphogenesis gene ANGUSTIFOLIA encodes a CtBP/BARS-like protein and is involved in the control of the microtubule cytoskeleton.
    EMBO J., 2002. 21(6): p. 1280-8
    [PMID:11889034]
  3. Tsukaya H
    The leaf index: heteroblasty, natural variation, and the genetic control of polar processes of leaf expansion.
    Plant Cell Physiol., 2002. 43(4): p. 372-8
    [PMID:11978864]
  4. Schnittger A,Hülskamp M
    Trichome morphogenesis: a cell-cycle perspective.
    Philos. Trans. R. Soc. Lond., B, Biol. Sci., 2002. 357(1422): p. 823-6
    [PMID:12079678]
  5. Nelissen H, et al.
    DRL1, a homolog of the yeast TOT4/KTI12 protein, has a function in meristem activity and organ growth in plants.
    Plant Cell, 2003. 15(3): p. 639-54
    [PMID:12615938]
  6. Cho KH,Shindo T,Kim GT,Nitasaka E,Tsukaya H
    Characterization of a member of the AN subfamily, IAN, from Ipomoea nil.
    Plant Cell Physiol., 2005. 46(1): p. 250-5
    [PMID:15659438]
  7. Stern MD, et al.
    Structurally related Arabidopsis ANGUSTIFOLIA is functionally distinct from the transcriptional corepressor CtBP.
    Dev. Genes Evol., 2007. 217(11-12): p. 759-69
    [PMID:17972097]
  8. Lin X, et al.
    Isolation and characterization of the Larix gmelinii ANGUSTIFOLIA (LgAN) gene.
    Planta, 2008. 228(4): p. 601-8
    [PMID:18560884]
  9. Bai Y,Falk S,Schnittger A,Jakoby MJ,Hülskamp M
    Tissue layer specific regulation of leaf length and width in Arabidopsis as revealed by the cell autonomous action of ANGUSTIFOLIA.
    Plant J., 2010. 61(2): p. 191-9
    [PMID:19843316]
  10. Minamisawa N, et al.
    ANGUSTIFOLIA, a plant homolog of CtBP/BARS, functions outside the nucleus.
    Plant J., 2011. 68(5): p. 788-99
    [PMID:21801251]
  11. Bai Y, et al.
    ANGUSTIFOLIA is a central component of tissue morphogenesis mediated by the atypical receptor-like kinase STRUBBELIG.
    BMC Plant Biol., 2013. 13: p. 16
    [PMID:23368817]
  12. Gachomo EW, et al.
    The cell morphogenesis ANGUSTIFOLIA (AN) gene, a plant homolog of CtBP/BARS, is involved in abiotic and biotic stress response in higher plants.
    BMC Plant Biol., 2013. 13: p. 79
    [PMID:23672620]
  13. Kwak SH,Song SK,Lee MM,Schiefelbein J
    ANGUSTIFOLIA mediates one of the multiple SCRAMBLED signaling pathways regulating cell growth pattern in Arabidopsis thaliana.
    Biochem. Biophys. Res. Commun., 2015. 465(3): p. 587-93
    [PMID:26296462]
  14. Chen L, et al.
    TCS1, a Microtubule-Binding Protein, Interacts with KCBP/ZWICHEL to Regulate Trichome Cell Shape in Arabidopsis thaliana.
    PLoS Genet., 2016. 12(10): p. e1006266
    [PMID:27768706]
  15. Sanz-Fernández M, et al.
    Screening Arabidopsis mutants in genes useful for phytoremediation.
    J. Hazard. Mater., 2017. 335: p. 143-151
    [PMID:28441590]
  16. Bhasin H,Hülskamp M
    ANGUSTIFOLIA, a Plant Homolog of CtBP/BARS Localizes to Stress Granules and Regulates Their Formation.
    Front Plant Sci, 2017. 8: p. 1004
    [PMID:28659951]
  17. Iwabuchi K, et al.
    ANGUSTIFOLIA Regulates Actin Filament Alignment for Nuclear Positioning in Leaves.
    Plant Physiol., 2019. 179(1): p. 233-247
    [PMID:30404821]
  18. Tsuge T,Tsukaya H,Uchimiya H
    Two independent and polarized processes of cell elongation regulate leaf blade expansion in Arabidopsis thaliana (L.) Heynh.
    Development, 1996. 122(5): p. 1589-600
    [PMID:8625845]
  19. Tsukaya H,Uchimiya H
    Genetic analyses of the formation of the serrated margin of leaf blades in Arabidopsis: combination of a mutational analysis of leaf morphogenesis with the characterization of a specific marker gene expressed in hydathodes and stipules.
    Mol. Gen. Genet., 1997. 256(3): p. 231-8
    [PMID:9393447]