PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Euphorbiaceae; Acalyphoideae; Acalypheae; Ricinus

Family

C2H2

Protein Properties

Length: 326aa MW: 37362.5 Da PI: 6.1264

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
30093.m000367	genome	JCVI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	13.5	0.00021	79	101	3	23
ET..TTTEEESSHHHHHHHHHHT CS zf-C2H2 3 Cp..dCgksFsrksnLkrHirtH 23 C+ Cgk+F + L++H H 30093.m000367 79 CSneGCGKTFIDAGALRKHAHIH 101 77779**************9877 PP
2	zf-C2H2	11.9	0.00071	106	130	1	23
EEET..TTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCp..dCgksFsrksnLkrHirtH 23 y C+ C+k F + s L+rH +H 30093.m000367 106 YACHyeGCTKKFLDGSKLRRHYLSH 130 89*******************9998 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:3.30.160.60	1.1E-12	72	102	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profile	PS50157	10.907	77	106	IPR007087	Zinc finger, C2H2
SMART	SM00355	0.013	77	101	IPR015880	Zinc finger, C2H2-like
SuperFamily	SSF57667	5.35E-6	78	102	No hit	No description
PROSITE pattern	PS00028	0	79	101	IPR007087	Zinc finger, C2H2
SuperFamily	SSF57667	3.16E-8	101	143	No hit	No description
Gene3D	G3DSA:3.30.160.60	2.0E-11	103	125	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SMART	SM00355	0.039	106	130	IPR015880	Zinc finger, C2H2-like
PROSITE profile	PS50157	12.695	106	135	IPR007087	Zinc finger, C2H2
PROSITE pattern	PS00028	0	108	130	IPR007087	Zinc finger, C2H2
Gene3D	G3DSA:3.30.160.60	1.6E-8	126	145	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Gene3D	G3DSA:3.30.160.60	9.4E-8	175	204	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SMART	SM00355	0.054	181	206	IPR015880	Zinc finger, C2H2-like
PROSITE profile	PS50157	9.473	181	211	IPR007087	Zinc finger, C2H2
PROSITE pattern	PS00028	0	183	206	IPR007087	Zinc finger, C2H2

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0003676	Molecular Function	nucleic acid binding
GO:0046872	Molecular Function	metal ion binding

Sequence ? help Back to Top
Protein Sequence Length: 326 aa Download sequence Send to blast
METQFIQNLF ERRSIIKSNA PAVKWFREWV PQDVAATGGR CLVLKWVTEN QLKALKEKNE 60 EPPEPEPEPE PTTEVLFLCS NEGCGKTFID AGALRKHAHI HGEKQYACHY EGCTKKFLDG 120 SKLRRHYLSH TGERDFICPH EGCGKHATVE PVKYATPLEK TAKIRKPSAG VYATPSPDHP 180 YACPYEGCIK AYIHEYKLKL HLRKEHPGHT SDEDAVHASL NADNYMNEAS DQDVYAEKRV 240 NRKSKKQNRA KPNLKMPPAK LTRRKGSSLS RATTNVVKKP WPVKEETYEE EDSEETEDED 300 RDDNAEDGWR YGENNEDDDE DTEHEE

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1ubd_C	2e-19	79	202	8	114	PROTEIN (YY1 ZINC FINGER DOMAIN)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Dual-function transcription factor with both repression and activation activities. Binds to 5'-CCATATT-3' motif in target gene promoters (e.g. ABR1) (PubMed:26961720). Binds also to G-rich DNA motif 5'-GGGGGCAGTGG-3' (PubMed:22508367). Regulates the expression of genes involved in diverse cellular pathways, including glucose metabolism, photosynthesis, phototropism and stress response (e.g. salt, drought and osmotic stress) (PubMed:22508367, PubMed:26961720). Regulates plant immunity, especially during necrotrophic fungal infection (e.g. B.cinerea) (PubMed:24451981). Binds to ABR1 promoter and promotes its expression, thus negatively regulating the abscisic acid (ABA) signaling pathway. Represses ABA- and salt-responsive genes expression (PubMed:26961720). {ECO:0000269\|PubMed:22508367, ECO:0000269\|PubMed:24451981, ECO:0000269\|PubMed:26961720}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	30093.m000367

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Induced by abscisic acid (ABA) in an ABI1- and ABI4-dependent manner. Stimulated by stress conditions including high salt, osmotic stress (e.g. mannitol) and dehydration. May be induced by ABI4 but repressed by ABR1. Repressed by darkness but induced by light. {ECO:0000269\|PubMed:26961720}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_015580751.1	0.0	zinc finger transcription factor YY1
Swissprot	Q2V3L3	1e-102	YY1_ARATH; Zinc finger transcription factor YY1
TrEMBL	B9SSP4	0.0	B9SSP4_RICCO; Uncharacterized protein
STRING	XP_002529013.1	0.0	(Ricinus communis)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF5649	33	54

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT4G06634.1	7e-98	C2H2 family protein

Link Out ? help Back to Top
Phytozome	30093.m000367

Publications ? help Back to Top
Kumekawa N,Hosouchi T,Tsuruoka H,Kotani H The size and sequence organization of the centromeric region of Arabidopsis thaliana chromosome 4. DNA Res., 2001. 8(6): p. 285-90 [PMID:11853315] Li T,Wu XY,Li H,Song JH,Liu JY A Dual-Function Transcription Factor, AtYY1, Is a Novel Negative Regulator of the Arabidopsis ABA Response Network. Mol Plant, 2016. 9(5): p. 650-661 [PMID:26961720] Wu XY,Li T A Casein Kinase II Phosphorylation Site in AtYY1 Affects Its Activity, Stability, and Function in the ABA Response. Front Plant Sci, 2017. 8: p. 323 [PMID:28348572]