PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Chrysanthemum seticuspe
Species TF ID Description
Cse_sc000102.1_g110.2MIKC_MADS family protein
Cse_sc000289.1_g110.1MIKC_MADS family protein
Cse_sc000306.1_g020.1MIKC_MADS family protein
Cse_sc001511.1_g010.1MIKC_MADS family protein
Cse_sc001511.1_g040.1MIKC_MADS family protein
Cse_sc002997.1_g030.1MIKC_MADS family protein
Cse_sc003129.1_g020.1MIKC_MADS family protein
Cse_sc003765.1_g080.1MIKC_MADS family protein
Cse_sc004019.1_g020.1MIKC_MADS family protein
Cse_sc004189.1_g020.1MIKC_MADS family protein
Cse_sc005132.1_g030.1MIKC_MADS family protein
Cse_sc005228.1_g020.1MIKC_MADS family protein
Cse_sc005308.1_g070.1MIKC_MADS family protein
Cse_sc005371.1_g030.1MIKC_MADS family protein
Cse_sc005701.1_g040.2MIKC_MADS family protein
Cse_sc006236.1_g040.1MIKC_MADS family protein
Cse_sc006661.1_g030.1MIKC_MADS family protein
Cse_sc007134.1_g020.1MIKC_MADS family protein
Cse_sc007234.1_g040.1MIKC_MADS family protein
Cse_sc008037.1_g040.1MIKC_MADS family protein
Cse_sc008335.1_g020.1MIKC_MADS family protein
Cse_sc008669.1_g010.2MIKC_MADS family protein
Cse_sc008670.1_g010.1MIKC_MADS family protein
Cse_sc009032.1_g010.1MIKC_MADS family protein
Cse_sc009312.1_g030.1MIKC_MADS family protein
Cse_sc010007.1_g010.1MIKC_MADS family protein
Cse_sc012654.1_g020.1MIKC_MADS family protein
Cse_sc012971.1_g050.1MIKC_MADS family protein
Cse_sc013015.1_g010.1MIKC_MADS family protein
Cse_sc013268.1_g040.1MIKC_MADS family protein
Cse_sc014091.1_g040.1MIKC_MADS family protein
Cse_sc014720.1_g030.1MIKC_MADS family protein
Cse_sc014932.1_g010.1MIKC_MADS family protein
Cse_sc015031.1_g010.1MIKC_MADS family protein
Cse_sc015618.1_g010.1MIKC_MADS family protein
Cse_sc015774.1_g010.1MIKC_MADS family protein
Cse_sc016675.1_g050.1MIKC_MADS family protein
Cse_sc017768.1_g020.1MIKC_MADS family protein
Cse_sc020934.1_g020.2MIKC_MADS family protein
Cse_sc027006.1_g010.1MIKC_MADS family protein
Cse_sc029063.1_g010.1MIKC_MADS family protein
Cse_sc029815.1_g010.1MIKC_MADS family protein
Cse_sc031470.1_g010.1MIKC_MADS family protein
Cse_sc032862.1_g010.2MIKC_MADS family protein
Cse_sc033361.1_g010.1MIKC_MADS family protein
Cse_sc035291.1_g020.1MIKC_MADS family protein
Cse_sc036426.1_g010.1MIKC_MADS family protein
Cse_sc037344.1_g010.1MIKC_MADS family protein
Cse_sc042534.1_g010.1MIKC_MADS family protein
Cse_sc044615.1_g010.1MIKC_MADS family protein
Cse_sc070541.1_g010.1MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513