PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Theobroma cacao
Species TF ID Description
Thecc1EG000266t1MIKC_MADS family protein
Thecc1EG000266t2MIKC_MADS family protein
Thecc1EG000266t3MIKC_MADS family protein
Thecc1EG000266t4MIKC_MADS family protein
Thecc1EG000931t1MIKC_MADS family protein
Thecc1EG000992t1MIKC_MADS family protein
Thecc1EG001182t1MIKC_MADS family protein
Thecc1EG001841t1MIKC_MADS family protein
Thecc1EG001841t2MIKC_MADS family protein
Thecc1EG005456t1MIKC_MADS family protein
Thecc1EG005456t2MIKC_MADS family protein
Thecc1EG005456t3MIKC_MADS family protein
Thecc1EG005456t4MIKC_MADS family protein
Thecc1EG005456t5MIKC_MADS family protein
Thecc1EG005458t1MIKC_MADS family protein
Thecc1EG005818t1MIKC_MADS family protein
Thecc1EG007324t1MIKC_MADS family protein
Thecc1EG007378t1MIKC_MADS family protein
Thecc1EG007378t2MIKC_MADS family protein
Thecc1EG007713t1MIKC_MADS family protein
Thecc1EG007713t2MIKC_MADS family protein
Thecc1EG008703t1MIKC_MADS family protein
Thecc1EG008703t2MIKC_MADS family protein
Thecc1EG008703t3MIKC_MADS family protein
Thecc1EG008716t1MIKC_MADS family protein
Thecc1EG008716t2MIKC_MADS family protein
Thecc1EG011475t1MIKC_MADS family protein
Thecc1EG011478t1MIKC_MADS family protein
Thecc1EG014337t1MIKC_MADS family protein
Thecc1EG014345t1MIKC_MADS family protein
Thecc1EG014345t2MIKC_MADS family protein
Thecc1EG014345t3MIKC_MADS family protein
Thecc1EG014661t1MIKC_MADS family protein
Thecc1EG014661t2MIKC_MADS family protein
Thecc1EG015044t1MIKC_MADS family protein
Thecc1EG015044t2MIKC_MADS family protein
Thecc1EG015044t3MIKC_MADS family protein
Thecc1EG015044t4MIKC_MADS family protein
Thecc1EG015049t1MIKC_MADS family protein
Thecc1EG015674t1MIKC_MADS family protein
Thecc1EG015674t2MIKC_MADS family protein
Thecc1EG016147t1MIKC_MADS family protein
Thecc1EG017242t1MIKC_MADS family protein
Thecc1EG018979t1MIKC_MADS family protein
Thecc1EG018981t1MIKC_MADS family protein
Thecc1EG018981t2MIKC_MADS family protein
Thecc1EG018981t3MIKC_MADS family protein
Thecc1EG024579t1MIKC_MADS family protein
Thecc1EG029596t1MIKC_MADS family protein
Thecc1EG029596t2MIKC_MADS family protein
Thecc1EG029596t3MIKC_MADS family protein
Thecc1EG029596t4MIKC_MADS family protein
Thecc1EG034148t1MIKC_MADS family protein
Thecc1EG034501t1MIKC_MADS family protein
Thecc1EG034549t1MIKC_MADS family protein
Thecc1EG034757t1MIKC_MADS family protein
Thecc1EG034970t1MIKC_MADS family protein
Thecc1EG035212t1MIKC_MADS family protein
Thecc1EG036541t1MIKC_MADS family protein
Thecc1EG036541t2MIKC_MADS family protein
Thecc1EG036568t1MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513