PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Triticum aestivum
LSD Family
Species TF ID Description
Traes_1AL_4B7636BC9.1LSD family protein
Traes_1BL_332C278BD.2LSD family protein
Traes_1DL_263F80870.1LSD family protein
Traes_5AL_4E653044F.1LSD family protein
Traes_5AS_B310AA218.1LSD family protein
Traes_5BL_4E60DC151.1LSD family protein
Traes_5BL_FC4E5FB7C.2LSD family protein
Traes_5BS_4179BB1C5.1LSD family protein
Traes_5DL_898B0A5A7.1LSD family protein
Traes_5DS_522EE613C.2LSD family protein
Traes_7AL_B58112C48.1LSD family protein
Traes_7BL_EE72D8712.1LSD family protein
Traes_7DL_C74CE92CC.1LSD family protein
LSD Family Introduction

Arabidopsis lsd1 mutants are hyperresponsive to cell death initiators and fail to limit the extent of cell death. Superoxide is a necessary and sufficient signal for cell death propagation. Thus, LSD1 monitors a superoxide-dependent signal and negatively regulates a plant cell death pathway. We isolated LSD1 via its map position. The predicted LSD1 protein contains three zinc finger domains, defined by CxxCxRxxLMYxxGASxVxCxxC. These domains are present in three additional Arabidopsis genes, suggesting that LSD1 defines a zinc finger protein subclass. LSD1 is constitutively expressed, consistent with the mutant phenotype. Alternate splicing gives rise to a low abundance mRNA encoding an extra five amino-terminal amino acids. We propose that LSD1 regulates transcription, via either repression of a prodeath pathway or activation of an antideath pathway, in response to signals emanating from cells undergoing pathogen-induced hypersensitive cell death.

Dietrich RA, Richberg MH, Schmidt R, Dean C, Dangl JL.
A novel zinc finger protein is encoded by the Arabidopsis LSD1 gene and functions as a negative regulator of plant cell death.
Cell, 1997. 88(5): p. 685-94.
PMID: 9054508

The most familiar form of plant programmed cell death is the hypersensitive response (HR) associated with successful plant immune responses. HR is preceded by an oxidative burst and the generation of both reactive oxygen intermediates (ROI) and NO. The Arabidopsis LSD1 gene encodes a negative regulator of plant programmed cell death that meets several criteria for a regulator of processes relevant to ROI management during pathogen responses. Here we demonstrate that a highly conserved LSD1 paralogue, LOL1, acts as a positive regulator of cell death. Manipulation of LOL1 expression alters both the superoxide-dependent, runaway cell death phenotype of lsd1 plants and the normal HR. We also show that LSD1 and LOL1 have antagonistic effects on copper-zinc superoxide dismutase accumulation, consistent with functions in cell death control via maintenance of ROI homeostasis.

Epple P, Mack AA, Morris VR, Dangl JL.
Antagonistic control of oxidative stress-induced cell death in Arabidopsis by two related, plant-specific zinc finger proteins.
Proc Natl Acad Sci U S A, 2003. 100(11): p. 6831-6.
PMID: 12732715