PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Medicago truncatula
NF-YA Family
Species TF ID Description
Medtr1g056530.1NF-YA family protein
Medtr1g056530.2NF-YA family protein
Medtr1g056530.3NF-YA family protein
Medtr2g030170.1NF-YA family protein
Medtr2g030170.2NF-YA family protein
Medtr2g041090.1NF-YA family protein
Medtr2g041090.2NF-YA family protein
Medtr2g099490.1NF-YA family protein
Medtr2g099490.2NF-YA family protein
Medtr3g061510.1NF-YA family protein
Medtr3g061510.2NF-YA family protein
Medtr7g106450.1NF-YA family protein
Medtr7g106450.2NF-YA family protein
Medtr8g019540.1NF-YA family protein
Medtr8g037270.1NF-YA family protein
Medtr8g037270.2NF-YA family protein
NF-YA Family Introduction

NF-Y transcription factors are likely found in all eukaryotes and have roles in the regulation of diverse genes (McNabb et al., 1995; Edwards et al., 1998; Maity and de Crombrugghe, 1998; Mantovani, 1999). In mammals, where their biochemistry is well described, the NF-Y transcription factor complex is composed of three unique subunits: NF-YA, NF-YB, and NF-YC. Assembly of the NF-Y heterotrimer in mammals follows a strict, stepwise pattern (Sinha et al., 1995, 1996). Initially, a heterodimer is formed in the cytoplasm between the subunits NF-YB and NF-YC. This dimer then translocates to the nucleus, where the third subunit, NF-YA, is recruited to generate the mature, heterotrimeric NF-Y transcription factor (Frontini et al., 2004; Kahle et al., 2005). Mature NF-Y binds promoters with the core pentamer nucleotide sequence CCAAT, and this can result in either positive or negative transcriptional regulation(Peng and Jahroudi, 2002, 2003; Ceribelli et al., 2008).

NF-YA proteins are characterized by the presence of Gln(Q)- and Ser/Thr(S/T)-rich NH2 termini, a subunit interaction domain (NF-YB/NF-YC interaction), and a DNA-binding domain (Olesen and Guarente, 1990; Maity and de Crombrugghe, 1992; Xing et al., 1993, 1994). The protein interaction and DNA binding domains are well conserved between plant and other eukaryote lineages.

Siefers N, Dang KK, Kumimoto RW, Bynum WE 4th, Tayrose G, Holt BF 3rd.
Tissue-specific expression patterns of Arabidopsis NF-Y transcription factors suggest potential for extensive combinatorial complexity.
Plant Physiol, 2009. 149(2): p. 625-41.
PMID: 19019982