PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Eutrema salsugineum
Species TF ID Description
Thhalv10000308mMIKC_MADS family protein
Thhalv10000598mMIKC_MADS family protein
Thhalv10001597mMIKC_MADS family protein
Thhalv10001631mMIKC_MADS family protein
Thhalv10001632mMIKC_MADS family protein
Thhalv10004767mMIKC_MADS family protein
Thhalv10004769mMIKC_MADS family protein
Thhalv10004826mMIKC_MADS family protein
Thhalv10004853mMIKC_MADS family protein
Thhalv10004949mMIKC_MADS family protein
Thhalv10004954mMIKC_MADS family protein
Thhalv10005055mMIKC_MADS family protein
Thhalv10005413mMIKC_MADS family protein
Thhalv10005641mMIKC_MADS family protein
Thhalv10006196mMIKC_MADS family protein
Thhalv10006419mMIKC_MADS family protein
Thhalv10008576mMIKC_MADS family protein
Thhalv10008591mMIKC_MADS family protein
Thhalv10010683mMIKC_MADS family protein
Thhalv10014493mMIKC_MADS family protein
Thhalv10014683mMIKC_MADS family protein
Thhalv10014716mMIKC_MADS family protein
Thhalv10014726mMIKC_MADS family protein
Thhalv10014738mMIKC_MADS family protein
Thhalv10015303mMIKC_MADS family protein
Thhalv10015598mMIKC_MADS family protein
Thhalv10017047mMIKC_MADS family protein
Thhalv10017157mMIKC_MADS family protein
Thhalv10018691mMIKC_MADS family protein
Thhalv10019025mMIKC_MADS family protein
Thhalv10019132mMIKC_MADS family protein
Thhalv10019686mMIKC_MADS family protein
Thhalv10019726mMIKC_MADS family protein
Thhalv10019795mMIKC_MADS family protein
Thhalv10021390mMIKC_MADS family protein
Thhalv10026116mMIKC_MADS family protein
Thhalv10026139mMIKC_MADS family protein
Thhalv10026205mMIKC_MADS family protein
Thhalv10026757mMIKC_MADS family protein
Thhalv10028938mMIKC_MADS family protein
Thhalv10028949mMIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513