PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Arabidopsis thaliana
NF-YA Family
Species TF ID Description
AT1G17590.1nuclear factor Y, subunit A8
AT1G17590.2nuclear factor Y, subunit A8
AT1G17590.3nuclear factor Y, subunit A8
AT1G17590.4nuclear factor Y, subunit A8
AT1G30500.1nuclear factor Y, subunit A7
AT1G30500.2nuclear factor Y, subunit A7
AT1G54160.1nuclear factor Y, subunit A5
AT1G72830.1nuclear factor Y, subunit A3
AT1G72830.2nuclear factor Y, subunit A3
AT1G72830.3nuclear factor Y, subunit A3
AT2G34720.1nuclear factor Y, subunit A4
AT3G05690.1nuclear factor Y, subunit A2
AT3G14020.1nuclear factor Y, subunit A6
AT3G20910.1nuclear factor Y, subunit A9
AT5G06510.1nuclear factor Y, subunit A10
AT5G06510.2nuclear factor Y, subunit A10
AT5G06510.3nuclear factor Y, subunit A10
AT5G12840.1nuclear factor Y, subunit A1
AT5G12840.2nuclear factor Y, subunit A1
AT5G12840.3nuclear factor Y, subunit A1
AT5G12840.4nuclear factor Y, subunit A1
NF-YA Family Introduction

NF-Y transcription factors are likely found in all eukaryotes and have roles in the regulation of diverse genes (McNabb et al., 1995; Edwards et al., 1998; Maity and de Crombrugghe, 1998; Mantovani, 1999). In mammals, where their biochemistry is well described, the NF-Y transcription factor complex is composed of three unique subunits: NF-YA, NF-YB, and NF-YC. Assembly of the NF-Y heterotrimer in mammals follows a strict, stepwise pattern (Sinha et al., 1995, 1996). Initially, a heterodimer is formed in the cytoplasm between the subunits NF-YB and NF-YC. This dimer then translocates to the nucleus, where the third subunit, NF-YA, is recruited to generate the mature, heterotrimeric NF-Y transcription factor (Frontini et al., 2004; Kahle et al., 2005). Mature NF-Y binds promoters with the core pentamer nucleotide sequence CCAAT, and this can result in either positive or negative transcriptional regulation(Peng and Jahroudi, 2002, 2003; Ceribelli et al., 2008).

NF-YA proteins are characterized by the presence of Gln(Q)- and Ser/Thr(S/T)-rich NH2 termini, a subunit interaction domain (NF-YB/NF-YC interaction), and a DNA-binding domain (Olesen and Guarente, 1990; Maity and de Crombrugghe, 1992; Xing et al., 1993, 1994). The protein interaction and DNA binding domains are well conserved between plant and other eukaryote lineages.

Siefers N, Dang KK, Kumimoto RW, Bynum WE 4th, Tayrose G, Holt BF 3rd.
Tissue-specific expression patterns of Arabidopsis NF-Y transcription factors suggest potential for extensive combinatorial complexity.
Plant Physiol, 2009. 149(2): p. 625-41.
PMID: 19019982